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59 articles for “therapeutic target”
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Research ArticleOpen accessIn the abstractDUAL ROLES OF CANCER CELL-EXPRESSED IMMUNOGLOBULINS IN CANCER IMMUNOLOGYGregory Lee, Cheng-Yuan Huang, Suefay Liu et al.While the expression of immunoglobulins and T cell receptors on cancer cells has been well-established for decades, the potential roles and mechanisms of action of these cancerous antigen receptors have not been fully elucidated. A monoclonal antibody designated as RP215, which reacts specifically with the carbohydrate-associated epitope located on the heavy chain region of cancerous immunoglobulins and T cell receptors, … …American Journal of Immunology, Vol. 10, Issue 3 · 2 Oct 2014 · 7,870 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Silico and in Vitro Studies: Tryparedoxin Peroxidase Inhibitor Activity of Methotrexate for Antileishmanial ActivityRavi Kumar Gundampati, Shraddha Sahu, Avinash Kumar Srivastava et al.In order to understand the mechanism of molecular interactions at the active site of Tryparedoxin Peroxidase (Try P), homology modeling and docking studies were performed. We generated a Three-Dimensional (3D) model of target protein based on the Crystal structure of Leishmania Major Try PI (PDB ID: 3TUE) using modeler software. Docking analysis was carried out to study the effects of … …American Journal of Infectious Diseases, Vol. 9, Issue 4 · 28 Nov 2013 · 7,894 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Metalloproteinase-9 Activities of Selected Indonesian Zingiberaceae Rhizome Extracts in Lipopolysaccharide-Induced Human Vascular Endothelial Cells In VitroYantiProblem statement: Atherosclerosis is associated with chronic inflammation triggered by bacterial infection that activates the breakdown of extracellular matrix protein by matrix Metalloproteinases (MMPs). Zingiberaceae, a group of tropical food crops grown in Indonesia and other Southeast Asia regions, has been traditionally used for food coloring, seasoning, culinary and medicinal purposes. However, its efficacy as natural vascular protection has not … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 1 · 27 May 2011 · 7,874 accessesView PDFCite
Research ArticleOpen accessIn the abstractErythema Multiforme Minor: A RevisionL. R. Oliveira, S. ZucolotoThe term Erythema Multiforme (EM) includes a wide and controversial variety of clinical expressions at the present time. This study revises the EM minor characteristics according to the most important publications found in literature. Erythema Multiforme is a distinct dermatologic hypersensitivity pathology characterized by cutaneous or mucous lesions and eventually it can also involve both. In their more severe forms, … …American Journal of Infectious Diseases, Vol. 4, Issue 4 · 31 Dec 2008 · 7,311 accessesView PDFCite
Research ArticleOpen accessIn the abstractHydrophobic, Polar and Hydrogen Bonding Based Drug-Receptor Interaction of TetrahydroimidazobenzodiazepinonesV.K. Sahu, A.K.R. Khan, R.K. Singh, P.P. SinghAnti-HIV drug discovery has been increasingly focusing on HIV-1-RT (reverse transcriptase) as a potential therapeutic target. Tetrahydroimidazobenzodiazepinone (TIBO) belongs to non-nucleoside group of reverse transcriptase inhibitors (NNRTIs). A computational chemistry study has been performed on a series of tetrahydroimidazo-benzodiazepinones as HIV-1-NNRT inhibitors. Problem statement: In order to search out new drug of desired activity from the lead compounds, there was … …American Journal of Immunology, Vol. 4, Issue 3 · 30 Sep 2008 · 8,839 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethamphetamine Inhibits β-Chemokines and Co-Stimulatory Molecule Expression by Dendritic CellsMadhavan P.N. Nair, Jose W. Rodriguez, Irina M. Borodowsky et al.The US is currently experiencing a serious epidemic of methamphetamine (Meth) use entangled with HIV-1 infection. Blood monocyte derived dendritic cells (DC ) are the first line of defense against HIV-1 infection and are the initial target of HIV-1 in injection drug users. Chemokines are known to be HIV-1 suppressing molecules and are positively associated with non- progression of HIV … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 6,546 accessesView PDFCite
Research ArticleOpen accessIn the abstractPDX-1 and MafA: Key Transcription Factors in PancreasHideaki Kaneto, Takeshi Miyatsuka, Yoshihisa Nakatani, Taka-aki MatsuokaPancreatic and duodenal homeobox factor-1 (PDX-1) plays a crucial role in pancreas development, β-cell differentiation and in maintaining normal β-cell function by regulating several β-cell-related genes including insulin. PDX-1 has potency to induce insulin-producing cells in non β-cells in various tissues such as pancreas and liver and PDX-1-VP16 fusion protein more efficiently induces insulin-producing cells, especially in the presence of … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,391 accessesView PDFCite
Research ArticleOpen accessIn the abstractUPLC-QTOF-MS/MS and Bioinformatics Association Analysis Reveals the Pharmacodynamic Flavonoids in Scutellaria barbata and the Underlying Anti-Colorectal Cancer MechanismYi-Jie Cheng, Xin-Yun Du et al.Colorectal Cancer (CRC) is one of the most common and deadly malignancies worldwide, with no safe and effective drugs. The flavonoid in Scutellaria Barbata D. Don (SB) showed a good therapeutic effect on CRC. However, the pharmacodynamic substances and underlying mechanisms have not been elucidated which limited its development and application. This study aimed to identify the main flavonoid in … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 14 Nov 2023 · 5,404 accessesView PDFCite
Research ArticleOpen accessIn the abstractExpression of microRNA miR-27, miR-124 and miR-218 Among Dental Pulp Stem Cell (DPSC) IsolatesMark Whiting, Karl KingsleyDental Pulp Stem Cells (DPSCs) are non-embryonic, mesenchymal stem cells that may have significant potential for therapeutic and regenerative biomedical applications. MicroRNAs are small non-coding RNA molecules that can act as transcriptional activators and repressors in many types of mesenchymal stem cells. To date, few studies have evaluated the expression or activity of microRNAs among dental pulp stem cells. Using … …Current Research in Dentistry, Vol. 9, Issue 1 · 1 Jan 2019 · 8,173 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,629 accessesView PDFCite