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161 results for “mice”
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Research ArticleOpen accessEvery word in the titleEffect of Intraperitoneally Injection of Different Doses of Lovastatin on Pain and Inflammatory Response Induced by Formalin in MiceKhayatnouri MirhadiProblem statement: The 3-Hydroxy-3-Methyl Glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality. Their lipid-lowering actions are by reversible and competitive inhibition of the enzyme HMG-CoA reductase, a precursor of cholesterol. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels, such as … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,679 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleToxicological Evaluation of Aspilia Africana Leaf Extracts in MiceO. O.K. Oko, E. A. Agiang, E. E. Osim, O. R. AsuquoProblem statement: The degree of toxicity of crude extracts of Aspilia Africana (Bush marigold) leaf on the basis of routes and dosages of administration were investigated. 204 healthy, male Swiss albino mice (20-25g) were used in three consecutive studies. Approach: In the first and second study, oral and intraperitoneal doses of 100, 500, 1000, 2000 and 4000 mg kg-1 body … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 28 Nov 2011 · 8,184 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAntidepressant-Like Activity of Banana Peel Extract in MiceTan Pei Tee, Halijah HassanProblem statement: Depressed mood, loss of interest or pleasure, feeling guilty, low selfesteem, sleep disturbance, loss of appetite, low energy and poor concentration are the characteristics of depression. This common mental disorder can occur in anyone regardless of genders, ages and backgrounds. People counteract it with psychotherapy and medications. Alternatively, some patients use herbal remedies as treatments. Recently, natural herbal … …Current Research in Medicine, Vol. 2, Issue 2 · 1 Oct 2011 · 18,671 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Nifedipine on Dichlorvos-Induced Seizure in MiceKhayatnouri MirhadiProblem statement: Dichlorvos a synthetic organophosphate poisons is the property of insecticide. These toxins as insecticides in agriculture and medicine for animals and the destruction of ectoparasites can be used. Studies have shown that Dichlorvos creation seizure effects in different animals. Nifedipine, dihydropyridine calcium channel blockers, widely used for treatment of cardiovascular diseases. Studies have shown that the calcium channel … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 2 · 17 Sep 2011 · 8,054 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleUltrastructural Changes in the Ileum of White BALB/C Mice Experimentally Infected with Salmonella hadarAfaf Abdulrahman Yousif, Maan M. Neima AL-NaqeebProblem statement: Recently, Salmonella hadar has been isolated and identified from goat in Iraq. The purpose of the present study was to investigate the ultrastructural changes in the ileum epithelial cells of mice experimentally infected with Salmonella hadar. Approach: The white BALB/c mice inoculated orally with Salmonella enterica serovar hadar strain and their ileums were examined by transmission electron microscopy … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 7,113 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Camel's Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino MiceMohamed E.M. AfifiProblem statement: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species. Camel's milk has good nutritive value, antigenotoxic and anticytotoxic effects. The aim of the present study was to assess the protective effect of camel's milk against Cisplatin-induced renal oxidative stress in mice. Approach: Forty mal … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,989 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Exercise Training on Adiponectin Receptor Expression and Insulin Resistance in Mice Fed a High Fat DietNaglaa Fathy Alhusseini, Nasr Arafat Belacy, Enas Mohammed Kasem, Mona Maher AllamProblem statement: Adiponectin is an adipocyte secreted hormones, exerts its effects via the specific receptors. AdipoR1 and adipoR2 and plays a pivotal role in lipid and glucose metabolism. Approach: We investigated the effect of increased physical activities on insulin resistance and if this effect is modulated through adiponectin receptor expression. Results: We also assessed the effect of High Fat Diet … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 9,951 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleReproductive Toxicology of Tartrazine (FD and C Yellow No. 5) in Swiss Albino MiceN. Mehedi, S. Ainad-Tabet, N. Mokrane et al.Problem statement: Tartrazine (FD and C Yellow No. 5) is an orange-colored widely used in food products, drugs and cosmetics. This color has a potential toxicological risk. The current study evaluated the effect of sub-chronic consumption of tartrazine on the male reproductive system. Approach: Tartrazine was administered to adult male mice in drinking water at doses of 0, 0.1, 1 … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 10,408 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA Model of Intestinal Anaphylaxis in Whey Sensitized Balb/c MiceNegaoui Hanane, Kaddouri Hanane, Kheroua Omar, Saidi DjamelProblem statement: Cow’s Milk Allergy (CMA) is a common disease in childhood. Pathophysiological mechanisms involved in gastrointestinal symptoms are relatively poorly understood. Approach: Therefore, an experimental model of intestinal anaphylaxis was needed to approach the problem. The aim of this study was to examine the effect of the parenteral sensitization to whey proteins through immune response and local intestine inflammation … …American Journal of Immunology, Vol. 5, Issue 2 · 30 Jun 2009 · 7,126 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleKidney Function Indices in Mice after Long Intake of Agaricus brasiliensis Mycelia (=Agaricus blazei, Agaricus subrufescens) Produced by Solid State CultivationDalla Santa Herta Stutz, Rubel Rosália, Vitola Francisco Menino Destéfanis et al.Problem statement: Agaricus brasiliensis (=Agaricus blazei, Agaricus subrufescens) or Sun mushroom has widespread use for potential health benefits such anti-tumor and immunomodulatory effects. Studies detected that others edible mushrooms affected renal metabolism and despite the widespread use of A. brasiliensis there are no studies that address biological effects on the renal function indices after their oral administration. Therefore, this study … …OnLine Journal of Biological Sciences, Vol. 9, Issue 1 · 31 Mar 2009 · 8,149 accessesView PDFCite