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47 articles for “malondialdehyde”
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Research ArticleOpen accessIn the abstractEndothelial Dysfunction and Insulin Resistance as Pathophysiologic Mechanisms in a Rat Model of PreeclampsiaAyman Z. Elsamanoudy, Amr M. AbbasProblem statement: To assess the plasma concentrations and placental gene expression of soluble fms like tyrosine kinase (sFlt-1), Vascular Endothelial Growth Factor (VEGF), visfatin and Tumour Necrosis Factor α (TNFα) in a rat model of preeclampsia, induced by chronic Reduction of Uterine Perfusion Pressure (RUPP) and to investigate the involvement of Insulin Resistance (IR) in the pathophysiology of preeclampsia and … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,503 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Camel's Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino MiceMohamed E.M. AfifiProblem statement: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species. Camel's milk has good nutritive value, antigenotoxic and anticytotoxic effects. The aim of the present study was to assess the protective effect of camel's milk against Cisplatin-induced renal oxidative stress in mice. Approach: Forty mal … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,989 accessesView PDFCite
Research ArticleOpen accessIn the abstractModulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon ExtractMohamed H. Mahfouz, Hala M. Ghanem, Mona A. MohamedCinnamon Extract (CE) has shown to be generally safe when ingested and to have many pharmacological properties. Problem statement: Study the effects of daily intake of CE on the modulation of hepatic, cardiac Insulin Receptor Substrate-1 (IRS-1) and their relations to some inflammatory variables in hyperinsulinemic rats. Approach: The influence of CE administered orally was studied in hyperinsulinemic rats. Eighteen … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 7,810 accessesView PDFCite
Research ArticleOpen accessIn the abstractPorcine Brain Extract Attenuates Memory Impairments Induced by Focal Cerebral IschemiaJinatta Jittiwat, Jintanaporn Wattanathorn, Terdthai Tongun et al.Problem statement: Stroke or cerebral ischemia has been recognized as one important problem worldwide. To date, the effectiveness of protective and therapeutic strategies against stroke is still very limited. Therefore, the development of novel strategy is required. Porcine brain is traditional believed to improve brain functions. Recent studies showed that the extract of porcine brain could protect against brain damage … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 14,615 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn vitro and In vivo Antioxidant Activity of Aphanamixis polystachya BarkAlluri V. Krishnaraju, Chirravuri V. Rao, Tayi V.N. Rao et al.Problem statement: Free radical stress leads to tissue injury and progression of disease conditions such as arthritis, hemorrhagic shock, atherosclerosis, diabetes, hepatic injury, aging and ischemia, reperfusion injury of many tissues, gastritis, tumor promotion, neurodegenerative diseases and carcinogenesis. Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. Approach: Many … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 8,734 accessesView PDFCite
Research ArticleOpen accessIn the abstractSesame Oil As A Protective Agent Against Doxorubicin Induced Cardio Toxicity In RatKaneez F. Shad, Suhail Al-Salam, Alaaeldin A. HamzaThe therapeutic value of doxorubicin (DXO) as anticancer antibiotic is limited by its cardiotoxicity. This study aimed to investigate the protective effect of sesame oil against DXO-induced cardiotoxicity and oxidative stress. The administration of DXO (20 mg/kg) to Wister male rats, increased serum aspartate aminotransferase and creatine kinase activities (as cardiotoxicity indices) as well as cardiac malondialdehyde and protein carbonyl … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 7,670 accessesView PDFCite
Research ArticleOpen accessIn the abstractIncreased Production of Nitric Oxide Contributes to Renal Oxidative Stress in Endotoxemic RatBahar Tunçtan, Belma Korkmaz, Hatice Yıldırım et al.Overproduction of reactive oxygen and nitrogen species leads to oxidative stress and decreased total antioxidant capacity, which is responsible for high mortality from several diseases such as endotoxic shock. Nitric oxide (NO) produced by inducible NO synthase (iNOS) during endotoxemia is the major cause of vascular hyporeactivity, hypotension and multiple organ failure. In this study, we investigated whether increased production … …American Journal of Infectious Diseases, Vol. 1, Issue 2 · 30 Jun 2005 · 8,638 accessesView PDFCite