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59 results for “lipid peroxidation”
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Research ArticleOpen accessIn the abstractCiprofloxacin Induced Chondrotoxicity and TendinopathyElias Adikwu, Nelson BrambaifaCiprofloxacin is one of the fluoroquinolones with a wide clinical acceptability. Rescently there are increasing reports on Ciprofloxacin induce Chondrotoxicity and Tendinopathy in Animal experiment and clinical experience which is of great clinical concern. A comprehensive survey and review of literaure on reported ciprofloxacin induced Chondrotoxicity and Tendinopathy in Humans and Animals was performed. It was observd that ciprofloxacin is … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 19 Oct 2012 · 10,420 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of New Compound with Antioxidant Potential in the Energy Metabolism of Adults Rats after Pneumococcal MeningitisT. Barichello, Geovana Dagostim Savi, A. P. Panatto et al.Problem statement: In bacterial meningitis, the Streptococcus pneumoniae can modify the cerebro-spinal fluid (CSF) homeostasis and initiation of the host inflammatory response with presence cytokine and leukocyte migration into the subarachnoidal space. Despite the availability of highly effective antibiotics, the disease is often fatal or causes long-term neurological problems in affected patients. Approach: The aim of this study was to … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 15 Jun 2012 · 7,792 accessesView PDFCite
Research ArticleOpen accessIn the abstractS-Allyl-Cysteines Reduce Amelioration of Aluminum Induced Toxicity in RatsSadhana ShrivastavaProblem statement: Aluminum (Al) is a trivalent cation found in its ionic form in most kinds of animal tissues and in natural waters everywhere. Approach: It is a potent neurotoxin and has been associated in the pathogenesis of several clinical disorders including Alzheimer’s disease. Results: The aim of the study was to demonstrate the protective effect of S-Allyl-Cysteines (SAC) against … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 12 Aug 2011 · 7,754 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of L-Carnitine and Cinnamon Extract Treatment on Lens Crystallins of Rats Fed High Fructose DietMohamed H. Mahfouz, Amany Abd El-Ghaffar, Mona A. Mohamed, Hala M. GhanemProblem statement: Rats fed high dietary fructose are documented to form an acquired model of insulin resistance; the present study aims to investigate possible changes in lens crystallins of rats fed high fructose diet and the effects of administration of each exogenous L-Carnitine (CA) and Cinnamon Extract (CE) on protein glycation, oxidative stress and redox homeostasis in this rat model. … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 3 Aug 2011 · 8,716 accessesView PDFCite
Research ArticleOpen accessIn the abstractCytotoxicity Studies of Superparamagnetic Iron Oxide Nanoparticles in Macrophage and Liver CellsAroonsri Priprem, Pramote Mahakunakorn, Chunpen Thomas, Ian ThomasSuperparamagnetic Iron Oxide Nanoparticles (SPIONs) prepared by simplified coprecipitation were attractive as MRI contrast agents and drug carriers which could internally be manipulated under the influence of an external magnetic field and also cancer treatment due to additional hyperthermia effects. Problem statement: Macrophage and liver cells are potentially exposed to internal SPIONs, thus used for this cytotoxic tests for safety … …Current Research in Nanotechnology, Vol. 1, Issue 2 · 22 Jun 2011 · 11,629 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of in vivo Antioxidant and Hepatoprotective Activity of Portulaca oleracea L. against Paracetamol-Induced Liver Toxicity in Male RatsMohamed H. AhmidaProblem statement: Oxidative stress plays a major role in paracetamol induced hepatotoxicity. Portulaca oleracea (P.O.) has been shown to exhibit antioxidant properties. The present study aimed to investigate the effect of P.O. on the oxidative stress in Paracetamol-induced hepatic toxicity in male rats. Approach: Forty male rats were divided into four groups. Group I served as control; Group II Received … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 7,329 accessesView PDFCite
Research ArticleOpen accessIn the abstractGermination Time Dependence of Bioactive Compounds and Antioxidant Activity in Germinated Rough Rice (Oryza sativa L.)Anuchita Moongngarm, Ekkalak KhomphiphatkulProblem statement: Germinated rice has been recognized as a functional food and its health benefits. However, most related studies were on germinated brown rice but our previous study indicated that germination of rough rice was an effective method to obtain high concentrations of bioactive compounds. Germination time is one of the most important factors affecting the level of biochemical compositions … …American Journal of Applied Sciences, Vol. 8, Issue 1 · 31 Jan 2011 · 8,670 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntioxidant Activity of Leaves of Calophyllum rubiginosumMuhammad Taher, Nissad Attoumani, Deny Susanti et al.Problem statement: Calophyllum species have been used in traditional medicine for their therapeutic values for many years. This use was explained by several previous studies where antimicrobial, antifungal, anti-HIV and anti-cancer and antioxidant compounds were isolated from several Calophyllum species. Approach: The leaves were extracted with n-hexane (hexane), dichloromethane (DCM) and methanol using soxhlet apparatus. Total phenolic contents of each … …American Journal of Applied Sciences, Vol. 7, Issue 10 · 31 Oct 2010 · 7,630 accessesView PDFCite
Research ArticleOpen accessIn the abstractNasal Administration of Quercetin Liposomes Modulate Cognitive Impairment and Inhibit Acetylcholinesterase Activity in HippocampusTerdthai Tong-Un, Supaporn Muchimapura, Wathita Phachonpai, Jintanaporn WattanathornProblem statement: Oxidative stress is a major factor implicated in the degeneration of cholinergic neurons in Alzheimer’s Disease (AD). Several reports have indicated that antioxidant intake is beneficial to delay or inhibit the progression of this disease. Presently, Acetylcholinesterase (AChE) inhibitors are the mainstay of therapy for AD. Quercetin, one of the flavonoids in fruits and vegetables, has a powerful … …Neuroscience International, Vol. 1, Issue 1 · 30 Jun 2010 · 7,173 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuroprotective Effect of Quercetin Encapsulated Liposomes: A Novel Therapeutic Strategy against Alzheimer’s DiseaseW. Phachonpai, J. Wattanathorn, S. Muchimapura et al.Problem statement: The prevalence of Alzheimer’s disease is increasing but the efficacy of treatment is still very limited due to various factors including the blood brain barrier. Recent findings demonstrated the crucial role of oxidative stress on the pathophysiology of disease. In addition the burden of blood brain barrier can be overcome by nasal administration and vesicle-carrier mediated delivery system. … …American Journal of Applied Sciences, Vol. 7, Issue 4 · 30 Apr 2010 · 9,458 accessesView PDFCite