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98 results for “Wistar Rats”
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Research ArticleOpen accessIn the abstractEffect of Exercise Prior or After Ischemia on the Density of Neurons and Astrocytes in the Brain of RatsLaila Cristina Moreira Damázio, Raphael Teixeira Rocha Melo, Maira de Castro Lima et al.The aim of this study was to analyse the density of astrocytes and neurons in the motor areas of the cortex, striatum and hippocampus of rats that performed exercise before or after cerebral ischemia. A total of 36 Wistar rats were separated into two groups: One that was subjected to Middle Cerebral Artery Occlusion (MCAO) and the other that underwent … …Neuroscience International, Vol. 5, Issue 2 · 14 Jan 2015 · 7,350 accessesView PDFCite
Research ArticleOpen accessIn the abstractEFFECT OF DIMETHOATE (AN ORGANOPHOSPHATE INSECTICIDE) ON THE REPRODUCTIVE SYSTEM AND FERTILITY OF ADULT MALE RATFerdinand Ngoula, Pierre Watcho, Augustave Kenfack et al.The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dimethoate is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. In the present study, we investigated the effect of dimethoate (an organophosphate insecticide) on the reproductive system and fertility of male … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 13 Feb 2014 · 8,598 accessesView PDFCite
Research ArticleOpen accessIn the abstractHEPATOTOXIC EFFECT OF ITRACONAZOLE IN EXPERIMENTAL RATSMohammed El-Hassan Abdelmaged KemeirItraconazole is a widely used antifungal drug. In situations such as managing patients with gastrointestinal basidiobolomycosis, third of which cases world-wide occur in the southwestern region of Saudi Arabia, prolonged treatment with this drug is required. Thus, this is study was designed to investigate the hepatotoxicity of long term administration of itraconazolein in Wistar rats. Two groups of rats were … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 1 · 30 Jan 2014 · 9,049 accessesView PDFCite
Research ArticleOpen accessIn the abstractEthanolic Extract of Leaves of Newbouldia laevis Attenuates Glycosylation of Hemoglobin and Lipid Peroxidation in Diabetic RatsKolawole O. Timothy, Akanji M. Adewumi, Awe O. Emmanuel, Akiibinu M. OlayemiDiabetes is one of the major health problems around the world and the incidence of this metabolic disorder is on the increase. Current therapeutic interventions have not done much in preventing complications of diabetes. Therefore this study investigated the effect of ethanolic extract of Newbouldia laevis leaves (NLet) on lipid peroxidation and glycosylation of hemoglobin, which are pathological indicators of … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 13 Nov 2013 · 8,126 accessesView PDFCite
Research ArticleOpen accessIn the abstractBIOCHEMICAL STUDIES ON NIGERIAN MONODORA TENUIFOLIA SEEDEkeanyanwu Raphael Chukwuma, Njoku Obioma UzomaThe nutritive constituents of the seeds of Monodora tenuifolia were analyzed to augment the available information on Monodora tenuifolia research. Blood glucose and lipid profile were investigated on the flavonoid rich fraction of M. tenuifolia in rats. The composition (gkg-1) of alkaloids, cyanogenic glycosides, tannins and flavonoids were 13.3±0.1, 21.2×10-2±0.6, 1.3±0.1, 1.7±0.1 and 11.7±1.1 respectively. The proximate composition (gkg-1) of … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 4 · 30 Sep 2013 · 7,575 accessesView PDFCite
Research ArticleOpen accessIn the abstractConstitutive Androstane Receptor Dependent and Independent Modulation of CYP3A2, CYP1A2 by Phenobarbital and Fibrate in Rats’ LiverMohamed Mohamed Ahmed, Mustafa Shukry, Zein Shaban Ibrahim et al.Cytochrome P450 enzymes, CYP3A and CYP1A are major drug metabolizing enzymes in the liver. CYP3A enzymes have a major role in the metabolism of 30-40% of all used drugs. CYP1A2 is a key enzyme having an important role in the metabolic clearance of 5% of currently marketed drugs. CYP1A2 participates in the metabolic activation of chemical mutagens in cooked food, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 7,384 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunomodulatory Activity of Argan Oil (Argania spinosa L)Youcef Necib, Ahlem Bahi, Sakina Zerizer et al.Immunomodulatory activity of Argan oil was evaluated on phagocytic activity by carbon clearance test. Adult Albinos Wistar rats randomly divided into four groups, were the first was served as a control, while animals of treatment group were given Argan oil at dose of: 2.5, 5 and 10 mL kg-1 by gavage respectively 10 days before injected the carbon ink suspension. … …American Journal of Immunology, Vol. 9, Issue 3 · 20 Aug 2013 · 6,935 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Acute Toxicity and Neuropharmacological Activities of PM-52Wipawee Thukhum-Mee, Jintanaporn Wattanathorn, Supaporn MuchimapuraThe neuropsychological disorders are increasing their importance nowadays. Unfortunately, the therapeutic efficacy is still not in satisfaction level. Therefore, the novel agents that are effective, safe, cheap and easy to approach are in required. Therefore, we aimed to determine the neuropharmacological activities of PM52, the novel herbal supplement. We had developed the PM52, a novel product comprising of Cissampelas pariera … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 2 · 27 May 2013 · 7,354 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Venom Studies on Olax viridis and Syzygium guineense ExtractsOmale James, Ebiloma Unekwuojo Godwin, Ogohi Dorathy AgahOlax viridis (Olacaceae) and Syzygium guineense (Myrtaceae) are shrubs commonly found in the tropics. They are traditional folkloric medicine for a great number of sicknesses. Olax viridis has a wide range of applications in ethnomedicine which include treatment for ulcers, veneral diseases, ringworm, sleeping sickness, diarrhea, fever. Syzygium guineense has been reported as antidiarrheal agent. Liquid from the bark and … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 12 Apr 2013 · 8,211 accessesView PDFCite
Research ArticleOpen accessIn the abstractPossible Mechanism of Plumbago zeylanica in Prevention of Hepatic Dammage in Wistar RatRohit Goyal, Pyare Lal SharmaPlumbago zeylanica root has been used traditionally to treat various body ailments including liver diseases. The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of Plumbago zeylanica root on paracetamol, CCl4 and alcohol induced hepatic injuries in rats and its possible mechanism(s) of hepatoprotection. Administration of hepatotoxicants like paracetamol (3 g kg-1, p.o.) or CCl4 … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,641 accessesView PDFCite