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Research ArticleOpen accessEvery word in the titleCELL DETACHMENT BY PROLYL-SPECIFIC ENDOPEPTIDASE FROM WOLFIPORIA COCOSNicole Mika, Katharina Cierpka, Michaela C. Lange et al.As requirements for Advanced Therapy Medicinal Product (ATMP) production differ from other production processes (e.g., therapeutic protein production), cell detachment is often a crucial step for the process success. In most cases, cell detachment is done enzymatically. Although many peptidases are established in cell culture in R&D, e.g., Trypsin as gold standard, many of them seem to be unsuitable in … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 8 Feb 2014 · 8,159 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleFREE ENERGY MEASUREMENT DISTINGUISHES NORMAL FROM CANCER CELL, OFFERING A NEW PERSPECTIVE FOR CURING CANCERKambiz Afrasiabi, Jonathan Melekh-ShalomThe interplay of the second law of thermodynamics with the normal state and the methodology needed for the measurement of free energy of normal and malignant cells and its practical implications has not been clearly addressed in current literature. The second law of thermodynamics is one of the most fundamental laws governing the known universe at all levels. A normal … …OnLine Journal of Biological Sciences, Vol. 13, Issue 4 · 12 Oct 2013 · 7,227 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleFlow Cytometry Baseline on Peripheral Leukocyte Cell Profiles for Dairy Goat KidsDarcy M. Fletcher, Megan B. Vogt, Hannah E. Pirner et al.Small ruminants, like goats, would make excellent animal models for not only infectious diseases in large ruminants but also analogous diseases in humans, such as human tuberculosis, Crohn’s disease, melioidosis and brucellosis. The main disadvantage for the small ruminant model is the lack of sufficient baseline data on normal, healthy goat kids. Furthermore, most reagents (antibodies and the like) were … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 4 · 26 Sep 2013 · 7,576 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleStability Analysis of Solar Cell Characteristics Above Room Temperature Using Indium Nitride Based Quantum DotMohd Abdur Rashid, Adawati Yusuf, Md. Abdullah Al Humayun et al.This study represents the improvement of stability of solar cell characteristics above room temperature. We have analyzed theoretically the temperature dependence of three major characteristics of solar cell using Ge and InN based quantum dot in the active layer of the device structure. Among the major characteristics of solar cell we have investigated the rate of change of open circuit … …American Journal of Applied Sciences, Vol. 10, Issue 11 · 9 Sep 2013 · 7,131 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAN EFFICIENT CELL PLACEMENT USING GRAVITATIONAL SEARCH ALGORITHMSRose Al Qasem, Taisir EldosIn modern chip design, cell placement is a stage in which cells representing well-defined functions are assigned physical locations, in a way that optimizes the total area and routing length. Cell placement is an NP-complete problem and the exact solution is generally far from reach for a practically sized instance. Hence, diversified heuristic algorithms are used to solve this problem. … …Journal of Computer Science, Vol. 9, Issue 8 · 25 Jun 2013 · 7,375 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMeasuring the Operating Efficiency of Solar Cell Companies in Taiwan with Data Envelopment AnalysisJui-Min HsiaoThis study discusses the Data Envelopment Analysis (DEA) approach to measure the operating efficiency of solar cell companies. With active and constructive advancement of the government, competition in the solar cell industry became even tenser. When drawing up the competitive strategies, one firm should identify the key indicators of its operating efficiency. This study incorporates three inputs (the number of … …American Journal of Applied Sciences, Vol. 9, Issue 12 · 7 Nov 2012 · 6,923 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMelanoma-Associated Suppression of the Dendritic Cell Lines DC2.4 and JawsiiKristian Michael Hargadon, Yonathan Tarekegne Ararso, Osric Anthony Forrest, Chad Mason HarteDendritic cells function as potent regulators of both innate and adaptive immunity to tumors and the regulatory activities of these cells are tightly linked to their maturation and activation status. Despite the critical role played by dendritic cells in the induction of anti-tumor immune responses, the number of dendritic cells that can be isolated from experimental animals is limiting and … …American Journal of Immunology, Vol. 8, Issue 4 · 3 Nov 2012 · 9,567 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Cell to Cell Interaction of Breast Cancer Cells Regulates Cancer Invasion Via ADAM15Daichi Ota, Masahiro Ikesue, Yutaka Matsui et al.Increasing evidence suggests that a disintegrin and metalloproteinase 15 (ADAM15) have essential roles in the process of cancer metastasis via degradation of the extracellular matrix and binding to integrins. Among them, ADAM15 possesses an Arg-Gly-Asp (RGD) sequence within its disintegrin domain (d.d., hereafter) and binds to RGD recognizing-integrins such as αvβ3 and α5β1 and also interacts with integrin α9β1 in … …American Journal of Immunology, Vol. 8, Issue 4 · 17 Oct 2012 · 7,690 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCell-Based Therapies in the Prevention of Solid Organ Transplant RejectionAdrian E. Morelli, Sherrie J. DivitoProblem statement: Organ transplantation is a life-saving and increasingly common procedure, as it often serves as the only treatment available for end-stage organ disease. Although the constant development of new and more effective immunosuppressive drugs has revolutionized the prevention and treatment of acute graft rejection, these drugs have significant toxicity, greatly increase patient susceptibility to neoplasms and infection and exert … …American Journal of Immunology, Vol. 8, Issue 2 · 26 Jul 2012 · 7,418 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMicrobial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus DiseaseWei JiangThe gut mucosal barrier disrupted in HIV disease, resulting in increased systemic exposure to microbial products such as Lipo Polys Accharide (LPS). The association of enhanced microbial translocation and B cell dysfunction in HIV disease is not fully understood. High dose and short term exposure of microbial Toll-Like Receptor (TLR) agonists were used as vaccine adjuvants, however, low dose and … …American Journal of Immunology, Vol. 8, Issue 2 · 30 Jun 2012 · 7,413 accessesView PDFCite