47 articles for “Risk Target”

Review ArticleOpen accessIn the abstractDrug Repositioning in Response to COVID-19 and other Challenging DiseasesHyellavala Joseph Fomnya, Saidu Ibrahim Ngulde, Sarah Malgwi Gana et al.Coronavirus disease is a highly contagious infection that is majorly associated with upper respiratory tract illnesses. The World Health Organization (WHO) label the novel coronavirus disease COVID-19 after an epidemic of the disease in Wuhan, Hubei province (China). Over 90 clinical trials, including drug repositioning, have been initiated to get COVID-19 treatment/management. Antibiotic resistance, drug tolerance, mutation, and adverse drug … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 28 Nov 2022 · 9,503 accessesView PDF Cite

Case ReportOpen accessIn the abstractIdentification and Management Implications of Fusobacterium Nucleatum PylephlebitisShoja Rahimian, Maria Labra, Ian Garrahy et al.Suppurativethrombophlebitis of the portal vein, or pylephlebitis, is a rare infectious manifestation. Only few casesresulting from Fusobacterium species have been reported, demonstratingthe disease that is in some ways analogous to Lemierre’s syndrome, orsuppurative thrombophlebitis of the internal jugular vein. Of these, Fusobacteriumnucleatum represents an important subtype with unique colon cancer risk.With high mortality rates up to 32% being described in … …American Journal of Infectious Diseases, Vol. 18, Issue 3 · 26 Sep 2022 · 5,689 accessesView PDF Cite

EditorialOpen accessIn the abstractBig Data and Parkinson’s Disease - from Understanding of Disease to Personalised MedicineYen F. Tai, Nicola PaveseThe advancement of information technology in recent years has generated a huge amount of datasets in all areas of scientific research. This has led to new opportunities to harness the 'Big Data' to improve our understanding of diseases - from investigating disease mechanisms to monitoring treatment responses. The Big Data approach is a data-driven and often hypothesis-free, way of studying … …Neuroscience International, Vol. 7, Issue 1 · 27 Jul 2016 · 7,755 accessesView PDF Cite

Research ArticleOpen accessIn the abstractLiquefaction Susceptibility in the Northern Provinces of ThailandSupot Teachavorasinskun, Pichai Pattararattanakul, Pulpong PongvithayapranuProblem statement: There are quite a few active faults recently found in the western and northern parts of Thailand, which could possibly induce earthquakes of magnitude (ML) of 5.5-6.5. Although seismic design code has been enforced in the area since 1980, the fundamental knowledge on dynamic soil behavior has not been extensively attained. Approach: Collection of existing borehole information in … …American Journal of Engineering and Applied Sciences, Vol. 2, Issue 1 · 31 Mar 2009 · 8,331 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEpigenetic Mechanisms in Hepatitis C Virus-Associated Hepatocellular Carcinoma: A Potential New Link Between Stem Cells, Virology and CancerQinghua Feng, Sajida Hassan, Trina Das et al.Recent studies suggest that epigenetic mechanisms are not only essential for the dynamic transcriptional regulation in embryonic and somatic stem cells, but are also actively involved in tumorigenesis: genes important for pluripotency are epigenetically regulated and aberrant epigenetic changes have been detected in virtually all human malignancies studied, including Hepatocellular Carcinoma (HCC). Infection with Hepatitis C Virus (HCV) is a … …Current Research in Medicine, Vol. 4, Issue 1 · 12 Mar 2013 · 8,038 accessesView PDF Cite

Research ArticleOpen accessIn the abstractFinding the Envelope and Efficient Frontier of Financial AssetsFarida Kachapova, Ilias KachapovProblem statement: One of the problems considered in financial mathematics is finding portfolios of given financial assets that minimize risk for targeted returns. The set of such portfolios is called the envelope of the assets. Traditionally this problem is solved as a calculus minimization problem involving partial derivatives and Lagrange multipliers. Approach: In this study we describe an invariant geometric … …Journal of Mathematics and Statistics, Vol. 8, Issue 3 · 16 Jul 2012 · 9,279 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Tumor/Immune Interface: Clinical Evidence of Cancer Immunosurveillance, Immunoediting and ImmunosubversionMatthew S. Block, Svetomir N. MarkovicProblem statement: The interactions of a malignant tumor with the patient’s immune system are dynamic, multiple and bi-directional. Approach: This article reviews the clinical evidence of the interaction of cancer with immunity with emphasis on recent developments highlighting some of the mechanisms of tumor-mediated regulation of immunity. Results: Most of the time, the immune response to a malignancy acts to … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 10,095 accessesView PDF Cite