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65 articles for “Mechanism of Action”
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EditorialOpen accessIn the abstractAMYOTROPHIC LATERAL SCLEROSIS: HOW TO UNDERSTAND SUCH DIVERSE AND SO ENTANGLED PHYSIOPATHOLOGY?Carlos Henrique Melo Reis, Marco Orsini, Marco Antônio Araujo Leite et al.When in 1865, JeanMartin Charcotreported patients with progressive muscular atrophysuperimposedwith spasticity of inexorable evolution as result of combinedlesions of the anterior horn and lateral column of the spinal cord, hecertainly inaugurated an attempt on the comprehension of one of the mostcomplexes neurological clinical conditions, which until today persists withimmense voids on their comprehension, regardless of the enormous advancesachieved. Astime went … …Current Research in Medicine, Vol. 5, Issue 2 · 16 Feb 2015 · 7,151 accessesView PDFCite
Research ArticleOpen accessIn the abstractEXERCISE TRAINING REVERSES THE DELETERIOUS EFFECT OF SUCROSE INTAKE ON INSULIN RESISTANCE AND VISCERAL FAT MASS DEPOSITION ON MICEJulio Cesar Mendes Soares, Vanderlei Folmer, Gustavo Puntel, João B.T. Da RochaAbnormal fat deposition has been identified as an important mechanism of obesity-associated with insulin resistance. Literature data also indicate that exercise can improve insulin action. The heme pathway enzyme δ-Aminolevulinate Dehydratase (δ-ALA-D) is a good marker for oxidative stress and this sulfhydryl enzyme is inhibited in such oxidative pathologies diabetes. The aim of this study was to evaluate the effects … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 28 Mar 2014 · 7,324 accessesView PDFCite
Research ArticleOpen accessIn the abstractEFFECT OF DIMETHOATE (AN ORGANOPHOSPHATE INSECTICIDE) ON THE REPRODUCTIVE SYSTEM AND FERTILITY OF ADULT MALE RATFerdinand Ngoula, Pierre Watcho, Augustave Kenfack et al.The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dimethoate is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. In the present study, we investigated the effect of dimethoate (an organophosphate insecticide) on the reproductive system and fertility of male … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 13 Feb 2014 · 8,598 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Cloning and Heterologous Expression of Human Interferon Alpha2b GeneI. Made Artika, Yemima Budirahardja, Anna Lucia EkowatiHuman alpha Interferons (hIFNα) have been shown to have antiviral, antiproliferative and immunomodulatory activities. The human interferon alpha2b (hIFNα2b), is one of the human interferon alpha2 sub variants, naturally synthesized as a polypeptide of 188 amino acid residues, the first 23 residues of which represents a signal peptide. In the present study, the hIFNα2b gene was expressed after being fused … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 4 · 20 Dec 2013 · 7,840 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Silico, In Vitro and In Vivo Assessment of Safety and Anti-inflammatory Activity of CurcuminM. Venkata, R. Sripathy, D. Anjana et al.Problem statement: Curcumin the active component of turmeric is known for its wide biological actions. Extensive studies on curcumin highlighted its anti-inflammatory, anti-oxidant, anti-microbial, anti-carcinogenic and anti-coagulant activity. The anti-inflammatory activities of curcumin have been demonstrated both in vitro and in vivo. Though curcumin and its anti-inflammatory properties are well documented, the exact mechanism of action and effective in vivo … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 23 Feb 2012 · 9,006 accessesView PDFCite
Research ArticleOpen accessIn the abstractThermodynamic Characteristics of Camel’s Urine as an Inhibitor for Mild Steel in 1.5 M H2SO4 Acid SolutionEhteram A. Noor, Azza A. Al-Ghamdi, Aisha H. Al-MoubarakiProblem statement: The corrosion inhibition of mild steel in 1.5 M H2SO4 by Camel’s Urine (CU) addition was evaluated at five different temperatures in the range from 30-70°C by weight loss measurements. CU acts as a good inhibitor for the corrosion of mild steel in 1.5 M H2SO4. The value of inhibition efficiency increases with increasing both inhibitor concentration and … …American Journal of Applied Sciences, Vol. 8, Issue 12 · 22 Oct 2011 · 7,373 accessesView PDFCite
Research ArticleOpen accessIn the abstractRespiratory Tract-Widening Effects of Dihydroartemisinin in Wistar Albino RatsUtoh-Nedosa Uchechukwu, Njoku Goddy, S. Nedosa Kenechi et al.Problem statement: Artemisinin-based anti-malarials are currently widely used in Asia and Africa. Not much is known about the systemic effect of dihydroartemisinin. This study therefore examine the effect of dihydroartemisinin on the lungs of Wistar albino rats. Approach: Five dosages of Dihydroartemisinin (DHA) were administered by oral intubation for 5 days to 5 test and 4 control Wistar albino rats. … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 7,517 accessesView PDFCite
Research ArticleOpen accessIn the abstractShear Strength of Reinforced Concrete Beam Strengthened by Transverse External Post-tensionSayan Sirimontree, Boonsap Witchayangkoon, Nathavudh Khaosri, Jaruek TeerawongProblem statement: Shear failure of concrete beam is brittle manner without warning so inadequate design for shear of beam and/or material deterioration lead to the possibility of sudden failure of beam. The change of functional use and future increased load of structure lead to the need for strengthening of concrete structure. Approach: This research focuses on behaviors under static loading … …American Journal of Engineering and Applied Sciences, Vol. 4, Issue 1 · 31 Jan 2011 · 8,869 accessesView PDFCite
Research ArticleOpen accessIn the abstractTaurine Implicated in Bromocriptine Induced Hallucination: Glycine-Glutamic-Aspartic Implicated in Bromocriptine Induced SchizophreniaAbdulrahim Abu JayyabProblem statement: The literature is reviewed and supports a strong anecdotal relationship between bromocriptine use and psychosis. It is well known that any interference with brain amino acid levels is likely to lead to disorder. Our previous research has shown that bromocriptine produced significant changes in the heart and kidneys amino acid contents. It has been confirmed that the brain … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 8,037 accessesView PDFCite
Research ArticleOpen accessIn the abstractRocks with Asbestos: Risk Evaluation by Means of an Abrasion TestBellopede Rossana, Clerici Carlo, Marini Paola, Zanetti GiovannaNaturally occurring asbestos and asbestiform minerals can be found in metamorphic rocks and in the soil of the alluvial plains. Problem statement: The definition of the "free-asbestos rock" and the limit to consider a rock or a soil safe is still a controversial issue. American and European laws did not present any method to define the hazard of the green … …American Journal of Environmental Sciences, Vol. 5, Issue 4 · 31 Oct 2009 · 7,672 accessesView PDFCite