46 results for “Macrophages”

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Research ArticleOpen accessIn the abstractMast Cells Inhibit CD8+ T Cell-Mediated Rejection of a Malignant Fibrous Histiocytoma-Like Tumor: Involvement of Fas-Fas Ligand AxisHiroshi Furukawa, Hiroshi Kitazawa, Izumi Kaneko et al.Problem statement: Mast cells develop from bone marrow-derived progenitor cells and are distributed in the skin or mucosa where they play proinflammatory roles in the first line of defense. Since some tumors in humans and experimental animals exhibited infiltration of increased mast cells, we investigated the contribution of mast cells to the override of tumor rejection. Approach: MRL/N-1 cells are … …American Journal of Immunology, Vol. 5, Issue 3 · 30 Sep 2009 · 7,670 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPeripheral Blood Leukocyte Production of BDNF following Mitogen Stimulation in Early Onset and Regressive AutismAmanda Enstrom, Charity Onore, Angela Tarver et al.Brain-derived neurotrophic factor (BDNF) is critical for neuronal differentiation and synaptic development. BDNF is also implicated in the development of psychological disorders including depression, bipolar disorder and schizophrenia. Previously, elevated BDNF levels were observed in neonatal blood samples from infants who were later diagnosed with autism when compared with children who developed normally, suggesting that BDNF may be involved in … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 8,525 accessesView PDF Cite

Research ArticleOpen accessIn the abstractT-2 Toxin Regulated Ganoderma lucidum Induced Cytokine ReleaseKazem Ahmadi, Majid RiazipourThe water-soluble extract of Ganoderma lucidum (Reishi) has been used as immunomodulator to stimulate spleen cells proliferation and cytokine expression. It has also been shown that at some level of exposure, T-2 toxin typically act as immunosuppressive agent and can increase disease susceptibility. The aim of this study was to investigate the effect of T-2 toxin on cytokine production by … …American Journal of Immunology, Vol. 4, Issue 1 · 31 Mar 2008 · 7,538 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCreation of Tetracycline Regulatable Knockouts of ORFF Gene from the LD1 Locus of Leishmania donovaniBindu Sukumaran, Manju Jain, Peter J. Myler et al.The tetracycline repressor/operator system was adapted for use in Leishmania donovani. In order to investigate the possible importance and function of open reading frame F (ORFF) in Leishmania donovani strain AG83 that has a single copy of ORFF in the LD1 locus on chromosome 35, we have attempted to generate tetracycline regulatable single allele mutants of ORFF. Leishmania cells expressing … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,829 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAqueous Extract of Inonotus bliquus (Fr.) Pilat (Hymenochaetaceae) Significantly Inhibits the Growth of Sarcoma 180 by Inducing ApoptosisCaifa Chen, Weifa Zheng, Xiaowen Gao et al.Inonotus obliquus (Fr.) Pilat (Hymenochaetaceae) has been widely used as a folk medicine to treat various cancers in Russia, Poland and most of Baltic countries for literally more than four centuries. However, in spite of its therapeutic significance for cancers, this fungus has not been studied systematically for the mechanisms of antitumor activity. In this study, we report the effects … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 21,110 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDietary supplementation with Cyperus esculentus L (tiger nut) tubers attenuated atherosclerotic lesion in apolipoprotein E knockout mouse associated with inhibition of inflammatory cell responsesMohamed L. Salem, Mohsen Zommara, K. ImaizumiAtherosclerosis is a pathological process, where recruitment of mononuclear cells results in the growth of fibro-fatty plaques. Apolipoprotein E (ApoE) is a legend for the uptake of lipoproteins, and deficiency of ApoE leads to the accumulation of low-density lipoprotein. Utilizing ApoE-/- mouse, which spontaneously develop atherosclerosis on low-fat chow diets, the present study showed that feeding these mice on a … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 10,471 accessesView PDF Cite