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57 results for “Drug Design”
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Research ArticleOpen accessIn the abstractDesign, Synthesis, Biological Screening and Structure Activity Relationship Study of 4, 6-Dimethyl-2-(Substituted) Mercapto-3-(Substituted) Pyridines as Anti Tubercular AgentsMehul M. Patel, Mahesh T. ChhabriyaProblem statement: Tuberculosis is a leading global mortality factor which has not been effectively controlled, with 1.7 million deaths per year and 8.9 million new cases. Aerobic microbe Mycobacterium tuberculosis H37Rv (MTB) is the causative agent of tuberculosis. Although many active antitubercular agents have since been developed, drug resistance will continue to be a problem. Therefore, there is a clear … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,430 accessesView PDFCite
Research ArticleOpen accessIn the abstractBinding Studies of Natural Product Berberine with DNA G-QuadruplexNagendra K. Sharma, Pooja Lunawat, Manjusha DixitProblem statement: The ends of chromosome had highly repetitive short G and C-rich sequences of DNA. These sequences were known to form stable tetraplex type of secondary structures which help to maintain gene integratity after cell divison. Approach: Any reagent which controls the random cell division would be useful to design anticancer drugs. Therefore a many natural and synthesized molecules … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 3 · 22 Sep 2011 · 8,797 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of U6 snRNA Transcription by PTENStephanie Cabarcas, Kounosuke Watabe, Laura SchrammProblem statement: RNA polymerase III (RNA pol III) is responsible for transcribing many of the small structural RNA molecules involved in RNA processing and protein translation, thereby regulating the growth rate of a cell. RNA pol III transcribes both gene internal (tRNA) and gene external (U6 snRNA) promoters and proper initiation by RNA polymerase III requires the transcription initiation factor … …OnLine Journal of Biological Sciences, Vol. 10, Issue 3 · 30 Sep 2010 · 8,551 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Comparative Study between Norethisterone Progestogens and Dydrogesterone in the Treatment of Dysfunctional Uterine BleedingNabila K. YaaqoubProblem statement: To compare the effects of both Norethisterone Progestongens and Dydrogesterone in the treatment of Dysfunctional Uterine bleeding Design: A prospective study. Setting: Tikrit Teaching Hospital, Iraq. Approach: About 200 patients presented with abnormal uterine bleeding and diagnosed as dysfunctional uterine bleeding were included in this study. Group A (study group): Include 100 patients were treated with norethisterone progestogens. … …Current Research in Medicine, Vol. 1, Issue 1 · 30 Jun 2010 · 15,135 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Anthelmintics Resistance Against Gastrointestinal Parasites Infection in Awassi Sheep in Jordan and The use of Alternative Herbal AnthelmenticsFiras Mahmoud Hayajneh, Hosam Hani Titi, Mufeed Awni Alnimer, Rabie IrshaidThis study aimed to uncover the prevalence of anthelmintic resistance in ovine gastrointestinal nematodes in middle and north Jordan and to check the in vivo anthelmintic efficacy of apple cider vinegar drench and ginger powder. For this purpose a parasitological study was designed, which used fecal egg count reduction test Two hundred seventy ewes were enrolled in this study, twenty … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 2 · 14 May 2019 · 8,058 accessesView PDFCite
Research ArticleOpen accessIn the abstractSildenafil in the Treatment of Postoperative Hypoxemia with High Resistance in Cyanotic Congenital Heart DiseaseZhou Jiawang, Lv Yong, Hu Zhendong et al.This study was designed to determine the effect of sildenafil treatment on postoperative hypoxemia with high resistance in cyanotic congenital heart disease. A total of 247 cases of cyanotic congenital heart disease were operated on from May 2006 to August 2014. Only 45 cases exhibited postoperative hypoxemia after symptomatic treatment. Sildenafil at doses of 0.30-5 mg/kg every 6 h was … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 3 · 1 Sep 2017 · 7,682 accessesView PDFCite
Research ArticleOpen accessIn the abstractAmeliorative Impacts of Tribulus terrestris Against Ivermectin-Induced Hepato-Renal Toxicity in Rabbit: Pharmacological and Histopathological StudySally I. Ismaiel, Sameh M. Farouk, Raafat A. El-Ramady, Waleed F. KhalilThe current work aimed to investigate the protective effects of Tribulus terrestris extracts against ivermectin-induced hepatic and renal toxicity in male rabbit. Selenium plus vitamin E was used as a comparative standard drug to evaluate the efficacy of Tribulus terrestris extract on some hematological parameters, kidney and liver enzymes as well as associated histopathological changes. This work was carried out … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 1 · 12 Jan 2017 · 7,766 accessesView PDFCite
Research ArticleOpen accessIn the abstractSelf Medication with Antibiotics among Medical and Pharmacy Students in North IndiaBiplab Pal, Krishna Murti, Ashok Kumar Gupta et al.Self medication practices among the medical and paramedical professionals have been reported in many countries, however, very limited research was done exclusively on antibiotic in North India. This study was designed to assess the prevalence and pattern of antibiotic usage for self diagnosed diseases among the medical and pharmacy students. This was a questionnaire based cross sectional study conducted among … …Current Research in Medicine, Vol. 7, Issue 2 · 30 Dec 2016 · 13,702 accessesView PDFCite
Research ArticleOpen accessIn the abstractDUAL ROLES OF CANCER CELL-EXPRESSED IMMUNOGLOBULINS IN CANCER IMMUNOLOGYGregory Lee, Cheng-Yuan Huang, Suefay Liu et al.While the expression of immunoglobulins and T cell receptors on cancer cells has been well-established for decades, the potential roles and mechanisms of action of these cancerous antigen receptors have not been fully elucidated. A monoclonal antibody designated as RP215, which reacts specifically with the carbohydrate-associated epitope located on the heavy chain region of cancerous immunoglobulins and T cell receptors, … …American Journal of Immunology, Vol. 10, Issue 3 · 2 Oct 2014 · 7,870 accessesView PDFCite
Research ArticleOpen accessIn the abstractINTERVENTION OF PHARMACOGENETIC PROFILING IN THERAPEUTICS OF KASHMIRI POPULATION, A LESSON LEARNED FROM CYP3A5*3 VARIANTAshaqullah Bhat, Aadil Wani, Rajinder Kaur et al.Human Cytochrome P450 3A, a variant of Cytochrome P-450- dependent monooxygenases is a major drug metabolizing enzyme. CYP3A has evolved to catalyze the biotransformation of its substrate. A great deal of inter-individual variation in expression levels exists for CYP3A5 gene. The common polymorphism in CYP3A5 that induces a cryptic splice site has been shown to cause a significant reduction in … …OnLine Journal of Biological Sciences, Vol. 14, Issue 3 · 10 Jul 2014 · 7,215 accessesView PDFCite