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82 articles for “Clinical Trial”
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Research ArticleOpen accessIn the abstractCoscinium Fenestratum Protects Against Ethanol-Induced Neurodegeneration in Adult Rat BrainWathita Phachonpai, Jintanaporn Wattanathorn, Panakaporn Wannanon et al.Alcoholism is a serious problem throughout the world. Despite intensive efforts to develop novel therapeutics for strategy efficacy against neuronal loss leading to memory impairment in alcoholism is still limited. In view of the pitfalls of psychological dependence and adverse behavioral effects of synthetic drugs, the development of low toxicity and high efficiency medicines derived from natural herbal antioxidants exhibits … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 16 Aug 2012 · 8,602 accessesView PDFCite
Research ArticleOpen accessIn the abstractInsulin Pump Therapy in Type 1 Diabetes-Merging Technology with Diabetes CareH. ThabitThe use of insulin pump therapy has been increasing over the past number of years in many countries. The Diabetes Control and Complications Trial (DCCT) have proven that better glycaemic control with fewer hypoglycemic events is achievable with insulin pump therapy. The delivery of subcutaneous insulin through an insulin pump mimics physiological insulin delivery better than Multiple Daily Injection of … …Current Research in Medicine, Vol. 3, Issue 2 · 22 May 2012 · 7,200 accessesView PDFCite
Research ArticleOpen accessIn the abstractMulberry Fruit Mitigates Alcohol Neurotoxicity and Memory Impairment Induced by Chronic Alcohol IntakeJintanaporn Wattanathorn, Nattaporn Phunchago, Supaporn Muchimapura et al.Problem statement: To date, the therapeutic strategy efficacy against memory impairment induced by alcohol intoxication is still limited. The novel therapeutic strategy which is easy to approach, less toxic and less cost is required. Based on the role of oxidative stress in memory impairment induced by alcohol, the neuroprotective effect of substance possessing antioxidant has gained much attention. Therefore, we … …American Journal of Applied Sciences, Vol. 9, Issue 4 · 8 Feb 2012 · 9,328 accessesView PDFCite
Research ArticleOpen accessIn the abstractDietary Beta-1,3/1,6-Glucans Reduce Clinical Signs of Canine AtopyA. C. Beynen, D. H.J. Saris, P. M. Paap et al.Problem statement: There was evidence that beta-1,3/1,6-glucans modulate inflammatory activity. In an open, non-controlled trial, purified beta-1,3/1,6-glucans were found to improve the clinical signs of dogs with undefined chronic skin disorders. Given the design of that study, further work was required on the efficacy of beta-1,3/1,6-glucans in the treatment of canine atopy. Approach: The influence of a purified preparation of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 9 Jan 2012 · 9,979 accessesView PDFCite
Research ArticleOpen accessIn the abstractDementia in Parkinson's Disease: A Clinical ReviewRenata Teles Vieira, Leonardo Caixeta, Sergio Machado, Marcelo CaixetaProblem statement: Idiopathic Parkinson's Disease (PD) has being increasingly seen as a neuropsychiatric entity and no longer purely neurological, given the frequency and exuberance with which the psychiatric manifestations occurs. Approach: This review will focus on the epidemiology, clinical aspects, differential diagnosis with Alzheimer's Disease (AD) associated with parkinsonism, Dementia with Lewy Bodies (LBD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration … …Neuroscience International, Vol. 2, Issue 1 · 23 Nov 2011 · 7,764 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Dietary Polydextrose on Feces Consistency and Macronutrient Digestibility in Healthy DogsK. Vasupen, C. Yuangklang, A. C. Beynen, A. W.C. EinerhandProblem statement: There is evidence that the addition of 3% STA-LITE® polydextrose to a dry food reduces clinical signs of osteoarthritis in dogs. For the application of polydextrose as functional ingredient of dog foods, information as to its impact on the acceptance of food, feces consistency, fecal odor and digestibility of macronutrients and minerals is required. Approach: A feeding experiment … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 3 · 5 Oct 2011 · 8,520 accessesView PDFCite
Research ArticleOpen accessIn the abstractImpact of Dietary Polydextrose on Clinical Signs of Canine OsteoarthritisA. C. Beynen, D. H.J. Saris, L. De Jong et al.Problem statement: Osteoarthritis is an inflammatory joint disease associated with loss of cartilage matrix. There is suggestive evidence that the intake of polydextrose fiber has anti-inflammatory activity. It was reasoned that polydextrose may have a positive influence on canine osteoarthritis. Approach: A double-blind, placebo-controlled trial with privately owned dogs was carried out to assess the efficacy of STA-LITE® polydextrose in … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 3 · 5 Oct 2011 · 9,052 accessesView PDFCite
Research ArticleOpen accessIn the abstractClinical Signs of Hairballs in Cats Fed a Diet Enriched with CelluloseA. C. Beynen, J. Middelkoop, D. H.J. SarisProblem statement: The intake of cellulose may delay gastric emptying and raise the intestinal transit rate. These effects could antagonize hairball formation. Thus, it was hypothesized that a diet enriched with a cellulose preparation (Arbocel BWW40®), forming a completely insoluble fiber network, would diminish the severity of clinical symptoms of hairballs in cats. Approach: In a double-blind, placebo-controlled trial with … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 2 · 8 Aug 2011 · 11,909 accessesView PDFCite
Research ArticleOpen accessIn the abstractUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDFCite
Research ArticleOpen accessIn the abstractBeneficial Effect of a Cellulose-Containing Chew Treat on Canine Periodontal Disease in a Double-Blind, Placebo-Controlled TrialA. C. Beynen, F. Van Altena, E. A. VisserProblem statement: There are indications that appropriate chew treats can contribute to the control of canine periodontal disease. It was reasoned that the incorporation of a cellulose fiber network into the treat may improve the efficacy, but for proof experimental data were required. Approach: A double-blind, placebo-controlled trial with privately owned dogs was carried out to assess the efficacy of … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 8,256 accessesView PDFCite