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48 results for “Clinical Signs”
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Research ArticleOpen accessIn the abstractUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDFCite
Research ArticleOpen accessIn the abstractBeneficial Effect of a Cellulose-Containing Chew Treat on Canine Periodontal Disease in a Double-Blind, Placebo-Controlled TrialA. C. Beynen, F. Van Altena, E. A. VisserProblem statement: There are indications that appropriate chew treats can contribute to the control of canine periodontal disease. It was reasoned that the incorporation of a cellulose fiber network into the treat may improve the efficacy, but for proof experimental data were required. Approach: A double-blind, placebo-controlled trial with privately owned dogs was carried out to assess the efficacy of … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 8,256 accessesView PDFCite
Research ArticleOpen accessIn the abstractSafety Assessment of Herbal Formulations, Rumbion™ and Tyrel™ in Albino Wistar RatsA.J. Joshua, K.S. Goudar, N. Sameera et al.Problem statement: Herbal remedies form one of the effective strategies for management of livestock healthcare. Despite the availability of extensive pharmacological information, the toxicological data on herbs and herbal preparations seem to be scanty. The objective of the present investigation was to evaluate the acute oral toxicity of some herbal veterinary preparations in albino Wistar rats. Approach: In the sighting … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 8,544 accessesView PDFCite
Research ArticleOpen accessIn the abstractRadiographic Evaluations of the Tetra-Calcium Phosphate and Diacalcium Phosphate with Bone Plate in Osseo-Integration of Bone Repair in RabbitDavood Sharifi, Sarang Soroori, Saeed Hasaraki, Nazanin JafariProblem statement: To determine the effect of the Tetra calcium phosphate and Diacalcium phosphate cement in comparison with bone plate in fracture repair in rabbit. Experimental in vivo study. A total of 18 adult male White New Zealand rabbits, weighing 3.0±0.250 Kg and about 6 months old were used. They were fasted 4 h before start of experiment and were … …American Journal of Animal and Veterinary Sciences, Vol. 4, Issue 4 · 31 Dec 2009 · 7,230 accessesView PDFCite
Research ArticleOpen accessIn the abstractVariability in Antihypertensive Drug Therapy and Compliance: Results from a Random Survey in the United Arab EmiratesSyed Azhar Syed Sulaiman, Muaed Jamal Alomar, Claire Caroline StrauchProblem statement: Hypertension is one of the most common diseases known as the ‘silent killer’ because it shows no clinical signs and symptoms. The high prevalence of hypertension in the United Arab Emirates stresses the importance to initiate a nation-wide effort to prevent and control high blood pressure in the population, especially since the prevalence rates are indicative of one … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 7,230 accessesView PDFCite
Research ArticleOpen accessIn the abstractGrowth, Feed Utilization and Haematology of Clarias gariepinus (Burchell,1822) Fingerlings Fed Diets Containing Different Levels of Vitamin CM. Adunni Adewolu, O. Olakunle AroProblem statement: In an effort to increase growth, improve feed utilization, reduce stress and prevent certain diseases, a 14 week feeding trial was conducted to determine the effects of different levels of dietary vitamin C (ascorbic acid) on growth, feed utilization and hematological changes in Clarias gariepinus fingerlings. Approach: Diets were formulated to contain 0, 50, 100, 150, 500, 1000 … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,698 accessesView PDFCite
Research ArticleOpen accessIn the abstractClinical and Surgical Findings and Outcome Following Rumenotomy in Adult Dairy Cattle Affected with Recurrent Rumen Tympany Associated with Non-Metallic Foreign BodiesZ. Bani Ismail, A. Al-Majali, K. Al-QudahMedical records of 31 adult dairy cows suffering from recurrent rumen tympany for at least 1 month duration that underwent exploratory laparotomy and rumenotomy were reviewed and information was obtained on signalment, history, physical examination findings, laboratory findings and surgical findings. Cases were categorized according to surgical findings into 3 groups. Group 1 (n = 10) included cattle with reticuloruminal, … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 3 · 30 Sep 2007 · 8,927 accessesView PDFCite
Research ArticleOpen accessIn the abstractTopical Cyclosporine A in Corneal Graft RejectionMahmood Nejabat, Jafar Khoshghadam, Masoomeh Eghtedari, Hamid HosseiniCorneal graft rejection is now the most common cause of graft failure after penetrating keratoplasty. This study was designed to determine whether, addition of 2% topical cyclosporine (CSA) to local and systemic steroids in treatment of endothelial corneal allograft rejection, would improve the outcome. A prospective randomized treatment trial was carried out on 40 consecutive corneal graft recipients, presenting with … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,317 accessesView PDFCite