43 results for “Cell viability”

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Research ArticleOpen accessIn the abstractIn vitro Activation of Human and Rat Lymphocyte and Macrophage Functions by NorepinephrineRicardo Gomez-Flores, Diana Caballero-Hernandez, Richard J. Weber et al.Norepinephrine (NE) has been associated not only with increasing blood pressure, atherosclerosis, heart disease, and other life threatening conditions, but also with altering immune responses by influencing leukocyte functions. In the present study, we evaluated the in vitro effects of NE on rat thymic lymphocyte and human peripheral blood mononuclear cells (HPBMC) functions. We observed that NE marginally, but significantly … …American Journal of Immunology, Vol. 1, Issue 4 · 31 Dec 2005 · 7,075 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEarly Cellular Responses of Purine Nucleoside-mediated Protection of Hypoxia-induced Injuries of Neuronal PC12 CellsBettina Tomaselli, Valerie Podhraski, Günther Böck, Gabriele Baier-BitterlichHypoxia in brain may lead to cell death by apoptosis and necrosis. In parallel adenosine, a powerful endogenous neuroprotectant is formed. We wanted to investigate the effect of adenosine and its purine nucleoside relatives, inosine and guanosine on early cellular responses to hypoxia. O2-sensitive neuronal PC12-cells were subjected to chemical hypoxia induced with rotenone, an inhibitor of mitochondrial complex I. … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,853 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordTrilobatin Possesses Protective Potentials on H2O2-Induced HepG2 Cells by Suppressing Oxidative Stress: Involvement of Nrf2/Keap1 Signal PathwayYuhan Zhai, Yuqing Zhang, Yaping Li et al.Trilobatin, a natural dihydrochalcone compound, possesses various biological activities. However, few investigations have been carried out on the mechanisms of trilobatin against oxidative stress. To comprehend the effects and mechanism of trilobatin on oxidative stress after hepatic injury, H2O2-induced HepG2 cells were used in this research. The results indicated that trilobatin enhanced the viability and improved the apoptosis morphology of … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 22 Dec 2023 · 5,087 accessesView PDF Cite