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66 articles for “Cell Proliferation”
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Research ArticleOpen accessIn the abstractThe Use of Artificial Neural Networks in Analysis Cationic Trypsinogen Gene and Hepatitis B Surface AntigenLiu Qicai, Zeng Kai, Zhuang Zehao et al.Problem statement: More and more severe hepatitis cases reported in China are infected with HBV and the immune response of HBV will be reduced if mutations occur in the TCR, therefore it is very important to investigate the relation of T-cellular function and clinical effect by studying the function of T-cell receptor. Approach: Artificial Neural Networks (ANN) was applied to … …American Journal of Immunology, Vol. 5, Issue 2 · 30 Apr 2009 · 7,566 accessesView PDFCite
Research ArticleOpen accessIn the abstractT-2 Toxin Regulated Ganoderma lucidum Induced Cytokine ReleaseKazem Ahmadi, Majid RiazipourThe water-soluble extract of Ganoderma lucidum (Reishi) has been used as immunomodulator to stimulate spleen cells proliferation and cytokine expression. It has also been shown that at some level of exposure, T-2 toxin typically act as immunosuppressive agent and can increase disease susceptibility. The aim of this study was to investigate the effect of T-2 toxin on cytokine production by … …American Journal of Immunology, Vol. 4, Issue 1 · 31 Mar 2008 · 7,541 accessesView PDFCite
Research ArticleOpen accessIn the abstractTherapeutic Effects of Phyllanthus Species: Induction of TNF-α-mediated Apoptosis in HepG2 Hepatocellular Carcinoma CellsSripathi M. Sureban, Dharmalingam Subramaniam, Paramasivam Rajendran et al.Phyllanthus species, especially P. amarus is a medicinal plant with hepatoprotective activity, believed to occur in part by inhibiting hepatitis B virus function. The pathogenesis mechanism of viral hepatitis is closely related to hepatocyte necrosis apoptosis. The aim of our study was to investigate the in vitro effects of extracts from three Phyllanthus species, P. urinaria, P. amarus and P. … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2007 · 9,009 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethamphetamine Inhibits β-Chemokines and Co-Stimulatory Molecule Expression by Dendritic CellsMadhavan P.N. Nair, Jose W. Rodriguez, Irina M. Borodowsky et al.The US is currently experiencing a serious epidemic of methamphetamine (Meth) use entangled with HIV-1 infection. Blood monocyte derived dendritic cells (DC ) are the first line of defense against HIV-1 infection and are the initial target of HIV-1 in injection drug users. Chemokines are known to be HIV-1 suppressing molecules and are positively associated with non- progression of HIV … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 6,546 accessesView PDFCite
Research ArticleOpen accessIn the abstractMicroarray Analysis of Human Vascular Smooth Muscle Cell Responses to Bacterial LipopolysaccharideJoe Minta James, J. Yun, Sandy Der, Shikha RanaAccumulating evidence suggest a causal role of bacterial and viral infections in atherogenesis. Bacterial lipopolysaccharide (LPS) has been shown to stimulate resting vascular smooth muscle cells (SMC) with the production of inflammatory cytokines and modulation of quiescent cells to the proliferative and synthetic phenotype. To comprehensively identify biologically important genes associated with LPS-induced SMC phenotype modulation, we compared the transcriptomes … …American Journal of Immunology, Vol. 3, Issue 2 · 31 Dec 2007 · 6,998 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of the Immunomodulatory Properties of a Calf Lipid Thymus Extract and Standardization of a Method for Quantification of its Biological ActivityMiodrag Colic, Radmila Popovic, Dusanka Mrdakovic et al.The aim of this study was to test the immunobiological properties of a new formulation of the lipid thymus calf extract (Thymsol), prepared for in vitro cell culture experiments. At first, we showed that Thymsol enhanced the antigen specific immune response in AO rats in vitro, using Keyhole limpet hemocyanin (KLH). At lower concentrations (0.5-2.5 μg mL-1) the extract increased … …American Journal of Immunology, Vol. 3, Issue 2 · 31 Dec 2007 · 7,045 accessesView PDFCite
Research ArticleOpen accessIn the abstractChromium Picolinate did not Effect on the Proliferation and Differentiation of MyoblastsM.C. Tsa, T.F. LienThis experiment is conducted in vitro to investigate trivalent chromium picolinate affects the proliferation and differentiation of myoblasts. A myoblasts cell line (C2C12) from rats was used in the experiment. These were randomly divided into the control group, the Pic group (50ppb picolinate) and the CrPic group (50ppb chromium picolinate). The differentiation of myoblasts reveals that the number of differentiated … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 4 · 31 Dec 2007 · 6,418 accessesView PDFCite
Research ArticleOpen accessIn the abstractInternalizing Versus Non-internalizing Receptors for Targeting L-Methioninase to Cancer CellsXiao-Ping Zang, Naveen R. Palwai, J. T. Pento, Roger G. HarrisonWe reported previously that L-methioninase targeted to the urokinase receptor of MCF-7 breast cancer cells is significantly more effective in inhibiting cell proliferation and migration than free L-methioninase both in vitro and in vivo. L-methioninase was targeted by linking at its amino terminus to an amino-terminal fragment (ATF) of urokinase. The ATF was selected for targeting because is has previously … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,818 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of AP-1 Antagonism in Growth Inhibition of Cervical Cancer Cell Lines by RetinoidsShennan Lu, Doris M. BenbrookRetinoid compounds induce multiple molecular effects that need to be taken into consideration in the development of theses agents as pharmaceuticals for cancer chemoprevention. Inhibition of cancer cell growth by retinoids is thought to occur through at least two mechanisms of transcriptional regulation resulting from direct binding of retinoids to nuclear retinoid receptors (RARs and RXR’s). First, the nuclear receptors … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,481 accessesView PDFCite
Research ArticleOpen accessIn the abstractLoss of Morphine-induced Suppression of NK Cell activity and T-cell Functions in µ-Opioid Receptor Knockout MiceRichard J. Weber, Ricardo Gomez-Flores, Ichiro Sora, George R. UhlIn vivo administration of µ-opioid receptor selective agonists to various species is known to suppress lymphocyte, NK cell, and macrophage functions, in addition to mediate pain relief and euphoria. Using a mouse model in which the µ-opioid receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in natural killer (NK) cell activity and T … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,941 accessesView PDFCite