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Research ArticleOpen accessAll words, across the recordDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordLifestyles and Migraine AttackHui Jun Chih, Wenbin LiangProblem statement: Migraine is a headache disorder of serious public health concerns as many sufferers are permanently disabled and incapable of carrying out simple daily routines. Migraine is contributed by biological and lifestyle factors. Understanding the association between these factors and migraine, particularly the modifiable lifestyle factors, can reduce the prevalence of this chronic disease and ease the burden on … …Current Research in Medicine, Vol. 2, Issue 2 · 2 Dec 2011 · 7,517 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordUse of Surface Energy to evaluate Adhesion of Bituminous Crack Sealants to AggregatesEllie H. Fini, Imad L. Al-Qadi, Taher Abu-Lebdeh, Jean-Francois MassonProblem statement: The performance of bituminous sealants in the field is partly controlled by properties and strength of the sealant-aggregate interface. The thermodynamic work of adhesion represents energy required for reversible separation of the two materials at the interface. The study of fracture includes the energy required for both reversible and irreversible processes during separation. Excess of work of facture … …American Journal of Engineering and Applied Sciences, Vol. 4, Issue 2 · 13 Jul 2011 · 7,884 accessesView PDFCite