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Research ArticleOpen accessIn the abstractIdentification of Novel Human Immunodeficiency Virus-1 Integrase Inhibitors by Shape-Based Virtual ScreeningT.K. Omprakash, A. Thamarai Selvan, A. Shahul Hameed, S.P. GeethaProblem statement: Human Immunodeficiency Virus-1 (HIV-1) is causative agent of the immune system disease, Acquired Immune Deficiency Syndrome (AIDS). Majority of anti-HIV drugs target reverse transcriptase and protease enzymes. Toxicity and development of multidrug resistant HIV-1 virus strains are the reasons for studying new targets in HIV-1 replication process for identifying novel inhibitor with low toxicity and high activity. Approach: … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Dec 2010 · 7,193 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntimicrobial Pattern and Clonal Dissemination of Extended-Spectrum Beta-Lactamase Producing Klebsiella Spp IsolatesSobhan Ghafourian, Nourkhoda Sadeghifard, Zamberi bin Sekawi et al.Problem statement: Gram-negative pathogens harboring ESBLs have caused numerous outbreaks of infections and are becoming an increasing therapeutic problem in many countries. The incidence of ESBL-producing strains among clinical isolates has been steadily increasing over the past years resulting in limitations of therapeutic option. The focus of this study was to examine the molecular epidemiology of ESBL-producing Klebsiella spp, investigate … …American Journal of Infectious Diseases, Vol. 6, Issue 4 · 31 Dec 2010 · 7,900 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Metabolite Combinations Produced by Lactobacillus plantarum on Plasma Cholesterol and Fatty Acids in PigletsT. V. Thu, Loh Teck Chwen, H. L. Foo et al.Problem statement: Hypercholesterol and fatty acids in plasma are the main causes for cardiovascular disease. Reduction of risk factors from diet that associated with cardiovascular disease has much attention in animals as well as in human. The objective of this study was to investigate the effects of feeding liquid metabolite combinations produced by five L. plantarum strains on the fatty … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 4 · 27 Dec 2010 · 7,635 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Cycle Duration and Phasing on Thermomechanical Fatigue of Dog-Bone Specimens Made form SteelAchegaf Zineb, Khamlichi Abdellatif, Francisco Mata CabreraProblem statement: Lifetime of standard dog-bone specimens made form steel as affected by phasing between thermal cycles and strains cycles and by cycle duration in thermomechanical fatigue is assessed under various conditions of loading. Approach: The methodology used was based on finite element post-processing analysis by specialized fatigue software package that takes into account coupling of damage from three primary … …American Journal of Engineering and Applied Sciences, Vol. 3, Issue 4 · 30 Nov 2010 · 7,700 accessesView PDFCite
Research ArticleOpen accessIn the abstractFrequency of P/S(XX)P Duplication and FRFE, Absence of LYP in P6Gag of Indian Human Immunodeficiency Virus-1 Subtype C IsolatesKrutika Wadekar, Sudhanshu Pandey, Preeti Jain et al.Problem statement: The presence of a p6 domain at the C-terminus of the Gag polyprotein is a characteristic feature of HIV-1 and other primate lentiviruses. The p6Gag protein is considered as a major phosphoprotein in mature HIV-1 virions and is involved in the viral assembly and budding process. Sequence variation in the p6gag region in HIV-1 has been associated with … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,531 accessesView PDFCite
Research ArticleOpen accessIn the abstractCharacterization of Escherichia coli Isolates from Commercial Layer Hens with SalpingitisMahmood Salehi, Reza GhanbarpourProblem statement: Escherichia coli isolates are the most common bacterial agents of salpingitis in commercial layer hens. The objectives of this study were to determine the phylogenetic groups/subgroups and antibiotic resistance of E. coli isolates from salpingitis cases in commercial layer hens farms in southeast of Iran. Approach: One hundred twenty one E. coli isolates from oviducts of layer hens … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 8,955 accessesView PDFCite
Research ArticleOpen accessIn the abstractDoes Predator Go for Size Selection or Preferential Toxic-Nontoxic Species Under Limited Resource?Joydeep Pal, S. Bhattacharya, J. ChattopadhyayProblem statement: Selectivity is common in predator-prey interaction but the selection mechanism is still unexplored and a debatable issue in modern theoretical and experimental ecology for numerous species across the globe. In present investigation we emphasized the hypothesis that the zooplankton is less inclined to opt the food based on size selectivity criteria than the preferential selectivity for the safe … …OnLine Journal of Biological Sciences, Vol. 10, Issue 1 · 30 Jun 2010 · 7,908 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunodeficiency Provides Partial Protection from Bone Loss Induced by Castration and OvariectomyCedo M. Bagi, Edwin Berryman, Nels Hanson et al.Problem Statement: The interaction of osteoblasts and osteoclasts with cells of the immune system has been suggested as a contributing factor in the development of osteoporoses. Evidence from studies in rodents suggests that T cells play a significant role in bone loss following estrogen deficiency. The goal of this study was to investigate whether the lack of functional T cells … …Current Research in Medicine, Vol. 1, Issue 1 · 30 Jun 2010 · 7,075 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntibacterial Activity of Marine Source Extracts Against Multidrug Resistance OrganismsNagi A. AL-Haj, Nurmas I. Mashan, Mariana N. Shamsudin et al.Problem statement: Antimicrobial resistance is the major problem of global dimensions with a significant impact on morbidity, mortality and healthcare-associated costs. The problem has recently been worsened by the steady increase in multiresistant strains and by the restriction of antibiotic discovery and development programs. Methicillin-resistant Staphylococcus aureus, pseudomonads and Escherichia coli are a major nosocomial and community-acquired pathogens for which … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 10,078 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntibiotic Susceptibility and Immunomodulatory Potential of Chosen Bacterial PathogensM. Sujatha, P. Dhasarathan, B. KarthickProblem statement: Antibiotic susceptibility is still the best way for bacterial pathogen escape mechanism against immunity. Approach: In the present investigation, bacterial pathogens like Staphylococcus aureus, Escherichia coli, Aeromonas hydrophila, Klebsiella and Pseudomonas aeruginosa were used to screen antibiotic susceptibility and immunomodulatory potential. Results: All the test pathogens were sensitive to all the test antibiotics 11±2 mm) except penicillin. The … …American Journal of Immunology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,831 accessesView PDFCite