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82 articles for “underlying mechanism”
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Research ArticleOpen accessIn the abstractRadiation Induced DNA Double Strand Break Studies of a Metal Sensitive Novel Bacterial Isolate from East Calcutta WetlandSanhita Chowdhury, Anindita Chakraborty, Ashoke Ranjan Thakur, Shaon Ray ChaudhuriProblem statement: This study was an attempt to isolate anaerobic microbes with potential for DNA double strand break repair using methanogen specific medium (DSMZ 120) from East Calcutta Wetland in India. It also intended to verify the specificity of the medium for isolation of the desired family of microbe. Approach: Culture based technique was used to obtain the pure isolate … …American Journal of Environmental Sciences, Vol. 5, Issue 3 · 30 Jun 2009 · 7,127 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvidence of Oxidative Stress in Autism Derived from Animal ModelsXue Ming, Michelle A. Cheh, Carrie L. Yochum et al.Autism is a pervasive neurodevelopmental disorder that leads to deficits in social interaction, communication and restricted, repetitive motor movements. Autism is a highly heritable disorder, however, there is mounting evidence to suggest that toxicant-induced oxidative stress may play a role. The focus of this article will be to review our animal model of autism and discuss our evidence that oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,121 accessesView PDFCite
Research ArticleOpen accessIn the abstractOn the Hormetic Behaviour of Drugs Binding to Different Redox States of Amine Oxidase EnzymesDeepak Narang, G. Reid McDonald, David J. Smith et al.Classical monoamine oxidases and copper-containing semicarbazide-sensitive amine oxidases are drug targets for a variety of established and novel pharmaceuticals used to treat conditions such as depression, Parkinsonism and inflammatory disorders. Development of enzyme inhibitors, both historically and currently, assumes an underlying adherence of these enzymes to Michaelis-Menten kinetic principles. In this mini-review, we discuss historical data from several laboratories and … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 6,931 accessesView PDFCite
Research ArticleOpen accessIn the abstractElucidating the Mechanism(s) of Hormesis at the Cellular Level: The Universal Cell ResponsePaul S. AgutterMany environmental stressors elicit biphasic effects from single cells. Such cellular hormesis may be interpreted in terms of (a) the superimposition of simple biochemical processes or (b) the non-specific behaviour of the cell. The latter approach is emphasized in this article and identified with the universal cell response (UCR); however, the importance of identifying molecular-level concomitants of the UCR is … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 13,118 accessesView PDFCite
Research ArticleOpen accessIn the abstractStructural Analysis of Spatial MechanismsFlorian Ion Tiberiu PetrescuThe paper briefly presents how structural analysis is performed on spatial mechanisms, presenting a practical application in the mechatronics of parallel robots, especially in Steward platforms. Structural analysis always helps to better understand the phenomena and especially the way the mechanisms are made. At spatial mechanisms the problems are a little more complex than those raised by plane mechanisms. For … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 2 · 26 May 2018 · 7,978 accessesView PDFCite
Research ArticleOpen accessIn the abstractResponses of Neural Cells (U87) to HCoV-229E and HCoV-OC43 InfectionsEun Ju Oh, Jae-Sik Jeon, Qian-Wen Wang, Jae Kyung KimRespiratory viruses, such as Coronaviruses (CoVs), can be neuroinvasive and exacerbate neurological pathologies via their capacity for direct viral replication and/or by inducing excessive host immune responses in the Central Nervous System (CNS). HCoV-229E is a primary COVID-19 and HCoV-OC43 is a beta COVID-19 belonging to the same genus as SARS-CoV-2 and both can cause acute infections in glioblastoma, neuroblastoma, … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 2 · 8 Jun 2023 · 5,186 accessesView PDFCite
EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,865 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin Iron (III) Complex Enhances Radiation-Induced Cell Death in Human Erythroleukemic Cell Lines by Increasing the Generation of Intracellular ROSJiraporn Kantapan, Krai Daowtak, Kachaporn Gateprayoon et al.Quercetin iron (III) complex (IronQ) is a paramagnetic agent which exhibits several biological effects. Despite extensive studies about quercetin metal complex, the role of complexes to enhance the effect of radiation still remains unexplored. To this end, we determined whether and how IronQ sensitizes cancer cells to Ionizing Radiation (IR). Doxorubicin resistant leukemic cells (K562/Adr) and their parental cell lines … …American Journal of Applied Sciences, Vol. 14, Issue 1 · 16 Jan 2017 · 8,068 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Seasonal Temperature on the Genotypic Variability of Flowering Duration in Pearl Millet (Pennisetum glaucum) in NigerSani Daouda Ousmane, Mouhamadou Mounkaila Boureima, Maman Nassourou Lawali et al.Heat stress is a major contributor to crop losses worldwide. Millet [Pennisetum glaucum (L.) R. Br.] is a staple crop for inhabitants of arid and semi-arid regions of the world, due to its extraordinary adaptation to drought and high temperatures. Climate change points to an overall increase in temperature, the effect of which on crop growth and productivity remains to … …American Journal of Agricultural and Biological Sciences, Vol. 17, Issue 1 · 30 Nov 2022 · 6,127 accessesView PDFCite
Research ArticleOpen accessIn the abstractSmart Orthopaedic Implants: Applications in Total Knee ArthroplastyMatthew K. Dion, John Drazan, Khaled Abdoun et al.Total knee arthroplasty is a common orthopaedic procedure conducted in the United States with approximately 700,000 surgeries performed annually. A common complication following total knee arthroplasty is anterior knee pain which affects tens to hundreds of thousands of people each year. The exact mechanism that leads to anterior knee pain remains unknown, but improper component selection may cause pathologic loading … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 23 Dec 2016 · 9,074 accessesView PDFCite