Sign inSubmit
Tips: “quotes” for a phrase · author:Lee · a DOI goes straight to its article

44 results for “transcription factor”
Set a search alert
Research ArticleOpen accessIn the abstractRole of Progranulin Gene Expression as a Molecular Biomarker for Bladder CancerSalwa M. Abo El-khair, Mie A. Mohamed, Tamer E. AlkhiaryBladder cancer is the second most common cancer of the urinary system. Early diagnosis of this tumor and estimation of risk of future progression has a significant impact on prognosis. Although there are several molecular markers for the diagnosis and prognosis for this tumor, their accuracy is not ideal. Progranulin is a growth factor that may play a critical role … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 2 · 22 Jun 2012 · 7,699 accessesView PDFCite
Research ArticleOpen accessIn the abstractLemon Pepper Fruit Extract (Zanthoxylum acanthopodium DC.) Suppresses the Expression of Inflammatory Mediators in Lipopolysaccharide-Induced Macrophages In VitroYanti, Theodorus Eko Pramudito, Nerissa Nuriasari, Katarina JulianaProblem statement: Lemon pepper fruits (Zanthoxylum acanthopodium DC.; Rutaceae) have been used as a traditional source against stomach ache by Batak people in North Sumatera province, Indonesia. However, its scientific evidence for treatment of inflammatory disorders particularly gastritis has not been reported. Approach: Here, we investigated the inhibitory effects of Lemon Pepper Fruit Extract (LPFE) against inflammatory biomarkers by conducting … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 4 · 14 Feb 2012 · 9,581 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Sequence Based Validation of Gene Expression Microarray DataGerhard G. Thallinger, Eva Obermayr, Pornpimol Charoentong et al.Problem statement: Quantitative Reverse Transcription PCR (RT-qPCR) is often used to validate microarray data. Previous studies show different levels of correlation, without further investigation of influencing factors. Approach: We compared expression levels of 381 genes obtained from microarray hybridizations and from TaqMan based RT-qPCR assays. Correlation of expression levels was determined by comparing: (i) single genes across samples, (ii) all … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 19 Jan 2012 · 13,715 accessesView PDFCite
Research ArticleOpen accessIn the abstractZinc Deficiency and Associated T-Cell Dysfunctioning among Human Immunodeficiency Virus SeropositivesM. Andrew Pradeep, M. Thiruvalluvan, V. Nalini, J. Stella MaryProblem statement: All the nutrients in the diet play a crucial role in maintaining an optimal immune response. In both, deficient and excessive intake of nutrients can have negative consequence on the immune status and susceptibility to a variety of pathogens. Zinc is an essential micronutrient for human growth development and immune function. It plays a vital role in structure … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 8,037 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of U6 snRNA Transcription by PTENStephanie Cabarcas, Kounosuke Watabe, Laura SchrammProblem statement: RNA polymerase III (RNA pol III) is responsible for transcribing many of the small structural RNA molecules involved in RNA processing and protein translation, thereby regulating the growth rate of a cell. RNA pol III transcribes both gene internal (tRNA) and gene external (U6 snRNA) promoters and proper initiation by RNA polymerase III requires the transcription initiation factor … …OnLine Journal of Biological Sciences, Vol. 10, Issue 3 · 30 Sep 2010 · 8,551 accessesView PDFCite
Research ArticleOpen accessIn the abstractFoxp3-Mediated Immunity of Human Pancreatic Cancer Cell Line PANC-1Renxi Wang, Gencheng Han, Jianan Wang et al.Problem statement: More and more evidences have shown that human cancer cells can express Foxp3, the regulatory T cell-associated transcription factor. The role of Foxp3 in human cancer cells is still unclear. We detected Foxp3 expression in human pancreatic cancer cell line PANC-1. SiRNA assays showed that Foxp3 expression suppressed the expression of TGF-β and IL-10 which could induce immune … …American Journal of Immunology, Vol. 5, Issue 4 · 11 Jan 2010 · 7,363 accessesView PDFCite
Research ArticleOpen accessIn the abstractDengue Virus Infection Induced NF-κB-dependent Macrophage Migration Inhibitory Factor ProductionLien-Cheng Chen, Huey-Wen Shyu, Huan-Yao Lei et al.Dengue virus (DV) infection can cause mild dengue fever or severe dengue hemorrhage fever and dengue shock syndrome. Macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in the modulation of inflammatory and immune responses and serum levels of MIF are correlated with disease severity in dengue patients. However, the mechanism that induces MIF production during … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,290 accessesView PDFCite
Research ArticleOpen accessIn the abstractTherapeutic Effects of Phyllanthus Species: Induction of TNF-α-mediated Apoptosis in HepG2 Hepatocellular Carcinoma CellsSripathi M. Sureban, Dharmalingam Subramaniam, Paramasivam Rajendran et al.Phyllanthus species, especially P. amarus is a medicinal plant with hepatoprotective activity, believed to occur in part by inhibiting hepatitis B virus function. The pathogenesis mechanism of viral hepatitis is closely related to hepatocyte necrosis apoptosis. The aim of our study was to investigate the in vitro effects of extracts from three Phyllanthus species, P. urinaria, P. amarus and P. … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2007 · 9,005 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Characterization of Soybean Mosaic Virus NIa Protein and its Processing Event in Bacterial ExpressionBong K. Choi, Jae S. Park, Hye J. Ahn et al.Soybean mosaic virus (SMV)-CN18 is an Rsv resistance-breaking (RB) isolate to overcome soybean resistance genes Rsv1, Rsv3 and Rsv4. The aim of this study was to characterize nuclear inclusion protein a (NIa protein) of RB isolate at the molecular level and demonstrate its processing into genome-linked protein (VPg) and NIa-Pro domains in Esherichia coli containing a bacterial expression pET vector … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,902 accessesView PDFCite
Research ArticleOpen accessIn the abstractOverdominance Effects between Malaria and Visceral Leishmaniasis in the 5q31 RegionMutaz Amin, Abdelbadea Elhassan, Kirk Rocket, Muntasir IbrahimA group of SNPs in 5q31, genotyped from Hausa tribe of Koka village in eastern Sudan; an area endemic with malaria and visceral leishmaniasis, were analyzed by The Leishmaniasis research group and found to have significant excess of heterozygosis level and departure from HWE and assumed to be due to natural selection resulting from notorious deadly outbreaks since various ethnic … …OnLine Journal of Biological Sciences, Vol. 15, Issue 4 · 18 Sep 2015 · 7,114 accessesView PDFCite