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44 results for “malaria”
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Research ArticleOpen accessIn the abstractDetection of Pesticide Residue in Dams and Well Water in Jazan Area, Saudi ArabiaHasan Y. Al-Hatim, Deifalla Alrajhi, Abdul Jabbar Al-RajabThe application of pesticides indoors and on agricultural lands increased dramatically in recent years in the Jazan area (Saudi Arabia) to control termites and the vectors of diseases, such as Rift Valley Fever (RVF) and malaria. This practice increased the potential risk of pesticide contamination of surface water and groundwater. In this study, samples of 44 wells and 3 dams … …American Journal of Environmental Sciences, Vol. 11, Issue 5 · 3 Nov 2015 · 7,943 accessesView PDFCite
Research ArticleOpen accessIn the abstractReverse Pharmacology-A Paradigm Shift for Drug Discovery and DevelopmentAshok D.B. VaidyaThe current scenario of drug discovery and development is facing a model perturbation, despite significant advances in genomics, proteomics, metabolomics, combinatorial chemistry and high through put assays. There is an urgent need of a paradigm shift in approaches to drug discovery. Natural products of Ayurveda offer a vast potential for novel phytomolecules with clinical activity. In India, Ayurveda is availed … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 15,398 accessesView PDFCite
EditorialOpen accessIn the abstractAre Heat Shock Proteins Druggable Candidates?Tawanda Zininga, Addmore ShonhaiBanumathy, G., V. Singh, S.R. Pavithra and U. Tatu, 2003. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. J. Biol. Chem., 278: 18336-18345. DOI: 10.1074/jbc.M211309200 Brehmer, D., S. Rudiger, C.S. Gassler, D. Klostermeier and L. Packschies et al., 2001. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nature Structural Molecular … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 2 Dec 2014 · 8,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractAspergillus Niger Metabolites Efficacies Against the Mosquito Larval (Culex Quinquefasciatus, Anopheles Stephensi and Aedes Aegypti) Population after Column ChromatographyNamita Soni, Soam PrakashProblem statement: Mosquito is a very common vector of several tropical diseases such as malaria, filariasis, dengue and chikungunya. Till todate, many xenobiotics have been used to control mosquito population and protect people from mosquito born diseases but increasing rate of resistance against these xenobiotics is a major concern in the disease control management. In contrast, extensive use of these … …Current Research in Microbiology, Vol. 2, Issue 1 · 21 Dec 2011 · 15,205 accessesView PDFCite
Research ArticleOpen accessIn the abstractErythropoietin-Like Effects of Dihydroartemisinin in Wistar Albino RatsUtoh-Nedosa Uchechukwu Anastasia, Nedosa Kenechi Stanislaus, Onyedibe Ikenna KennethArtemisinin drugs were active during the intra-erythrocytic stage of malaria parasite infection. The activity of artemisinin and synthetic endoperoxides was related to their interaction with heme. The electrophillic intermediate formed from artemisinin in the presence of heme alkylates the protein portion of hemoglobin preferentially to the heme portion. Problem statement: Since there might be an interaction between artemisinin and the … …American Journal of Agricultural and Biological Sciences, Vol. 6, Issue 4 · 9 Dec 2011 · 7,785 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of the Toxic Effects of Dihydroartemisinin on the Vital Organs of Wistar Albino RatsA. U. Utoh-Nedosa, P. A. Akah, T. C. Okoye, C. O. OkoliProblem statement: The current surge in the use of Artemisinin based Combination Therapy (ACT) in the treatment of falciparium resistant malaria in the tropics and the potentials of Dihydroartemisinin (DHA), a member of the artemisinin family, to produce toxic effect in the vital organs (such as the liver, heart, lungs, intestine, spleen kidney and blood cells) necessitated this research. Approach: … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 9,181 accessesView PDFCite
Research ArticleOpen accessIn the abstractPlasma Bilirubinaemia; A Physiologic Index for Monitoring Cellular Effects of Amalar, Chloroquine, Cotecxin and FansidarE. O. Jimmy, I. F. UsohProblem statement: Antimalaria drugs are highly consumed in Africa due to increase prevalent of malaria attacks. Though the disease is often cured with some antimalarials the physiologic effects of such drugs may not be considered in pharmacologic preparations and in prescriptions. Such non consideration is likely to result in serious health problems which may outweigh the effects of malaria disease … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 7,541 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunomodulatory and In vivo Antiplasmodial Activities of Propolis ExtractsSyamsudin, Rita Marleta Dewi, KusmardiProblem statement: Malaria caused by various species of prozoan parasites, Plasmodium. The exact mechanism of humoral immunity in eliminating Plasmodium is not completely understood. However, an antimalarial antibody is strongly suspected to play important role in immunity. The purpose of this research was to evaluate the immunomodulator and antiplasmodial activities of Indonesian propolis extracts. Approach: Thirty male BALB/c mice weighing … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 7,801 accessesView PDFCite