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Research ArticleOpen accessIn the abstractNon-Target Inhibition of Antioxidant Enzymes in Honey Bees (A. mellifera and A. florea) Upon Pesticide ExposureAmal Ahmed Berjawi, Syed Salman Ashraf, Mohammad Ali Al-DeebUnderstanding how different insecticides influence bee health is very essential. The aim of this work was to evaluate enzyme kinetics and inhibition by insecticides in Apis mellifera and Apis florea. Tested enzymes showed variable affinity to substrates. In A. florea, glutathione S-transferase (GST) showed significantly higher affinity for its 1-Chloro-2,4-Dinitrobenzene (CDNB) substrate than in A. mellifera. Carbosulfan caused the highest … …OnLine Journal of Biological Sciences, Vol. 20, Issue 2 · 10 Apr 2020 · 7,401 accessesView PDFCite
Research ArticleOpen accessIn the abstractPROTECTIVE ROLE OF VITAMIN C AND GREEN TEA EXTRACT ON MALATHION-INDUCED HEPATOTOXICITY AND NEPHROTOXICITY IN RATSRabab R. Elzoghby, Ahlam F. Hamoda, A. Abdel-Fatah, Mona FaroukThe present study was designed to determine the modulating effect of green tea and vitamin C against adverse effects of malathion. Animals were divided into four groups 5 rats /group). Group one was used as a control. Group two given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks). Group three and Group four were given malathion (50 mg/kg/day; … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 3 · 22 Jul 2014 · 8,174 accessesView PDFCite
Research ArticleOpen accessIn the abstractIMPACT OF DEHYDROEPIANDROSTERONE IN PREVENTION OF PARACETAMOL INDUCED NEPHROTOXICITY IN RATSAbbas O. ElkaribParacetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. However, Dehydroepiandrosterone (DHEA), the major secretory product of the human adrenal gland, has been shown to possess a multi-targeted antioxidant activity which is also effective against lipid peroxidation induced in various animal models and against various human disorders. In this study, the … …Current Research in Medicine, Vol. 5, Issue 1 · 26 Mar 2014 · 7,568 accessesView PDFCite
Research ArticleOpen accessIn the abstractCognitive-Enhancing and Antioxidant Activities of Quercetin Liposomes in Animal Model of Alzheimer's DiseaseTerdthai Tong-un, Panakaporn Wannanon, Jintanaporn Wattanathorn, Wathita PhachonpaiProblem statement: Recent findings demonstrated the crucial role of oxidative stress on the pathophysiology of Alzheimer’s Disease (AD). Antioxidant intake is beneficial to delay or inhibit the progression of this disease. Quercetin, a bioflavonoid in fruits and vegetables, has a powerful antioxidant activity both in vitro and in vivo. Claims that quercetin has many biological activities. However, quercetin is rapidly … …OnLine Journal of Biological Sciences, Vol. 10, Issue 2 · 31 Oct 2010 · 7,884 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Camel's Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino MiceMohamed E.M. AfifiProblem statement: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species. Camel's milk has good nutritive value, antigenotoxic and anticytotoxic effects. The aim of the present study was to assess the protective effect of camel's milk against Cisplatin-induced renal oxidative stress in mice. Approach: Forty mal … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,994 accessesView PDFCite
Research ArticleOpen accessIn the abstractCamel's Milk Protects Against Cadmium Chloride-Induced Hypocromic Microcytic Anemia and Oxidative Stress in Red Blood Cells of White Albino RatsMohammad DallakProblem statement: Cadmium is a heavy metal of wide occupational and environmental contamination. In recent years, however, Cadmium has been implicated in the pathogenesis of several clinical disorders. One of the most frequently described problems in aluminum toxicity is anemia. Therefore, the present study was carried out to determine the effectiveness of Camel's milk in alleviating the toxicity of Aluminum … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 8,688 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Frequency of Polymorphisms affecting Lead and Mercury Toxicity among Children with AutismShannon Rose, Stepan Melnyk, Alena Savenka et al.Individual risk of developmental neurotoxicity with exposure to environmentally relevant levels of lead and mercury is likely to be determined by genetic susceptibility factors as well as additive interactions with other environmental pollutants, cumulative dose, and the developmental stage of exposure. The apparent increase in autism diagnosis over the last 15 years has enhanced interest in the possibility that an … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,524 accessesView PDFCite
Research ArticleOpen accessIn the abstractPolycyclic Aromatic Hydrocarbon Accumulation and Biomarker Responses in Cockles from Moroccan Mediterranean CoastsIkram Chbani, Saida Bouzid, Nourredine Bouayad, Hassan Er-RaiouiThis study aims to evaluate levels and effects of Polycyclic Aromatic Hydrocarbons (PAHs) in cockles (Acanthocardia tuberculatae) collected from two differently influenced areas in the Mediterranean Western Moroccan coasts. PAHs accumulation was studied in soft tissues using Soxhlet extraction and separation on silica column methods. The measure of those organic compounds was realized by Gas chromatography coupled to Mass spectrometer … …American Journal of Environmental Sciences, Vol. 15, Issue 4 · 30 Jul 2019 · 7,503 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of Phenolic Content and Antioxidant Properties of Selected Cowpea Varieties Tested in Bovine Peripheral BloodSarah Adjei-Fremah, Louis EN Jackai, Mulumebet WorkuCowpea is an important grain legume with a dual purpose function as a food and feed resource. Cowpea contains phenolic compounds that are beneficial to human and animal health. We evaluated the phenolic content, condensed tannin content and antioxidant capacities of methanol extracts of seed and leaf of seven varieties commonly used in food and animal feed. The total phenolic … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 4 · 19 Dec 2015 · 7,874 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Combined Fenofibrate and Nicotinamide on Oxidative Stress and Inflammatory Cytokines Involved in Cisplatin-Induced Nephrotoxicity in RatsOmaima M. Abd Allah, Abeer A.I. Sharaf El-Din, Fouad El DebakeyCisplatin (Cis) is an anticancer drug, which is accompanied with major side effects including nephrotoxicity. The current study was performed to assess the possible prophylactic effects of fenofibrate (FEN), Nicotinamide (NAM) and their combination on oxidative stress and inflammatory cytokines associated with cisplatin-induced renal damage. Rats were randomly divided into seven groups (8 each) as follows; control group; FEN group … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 9 Jan 2015 · 7,131 accessesView PDFCite