327 articles for “exposure”

Research ArticleOpen accessEvery word in the titleP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,504 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleMountain Sheep: An Environmental Epidemiological Survey of Variation in Metal Exposure and Physiological Biomarkers Following Mine DevelopmentLawrence K. Duffy, Michael W. Oehler, R. Terry Bowyer, Vernon C. BleichProblem Statement: Anthropogenic activities, such as mining and industrial operations, are a major environmental source of metal exposure for wildlife. Quantitative data regarding biochemical effects of exposure to mineral extraction on mountain sheep, Ovis canadensis, are limited, although their habitats are becoming increasingly affected by expanded resource development. Decisions relating to environmental protection and wildlife conservation should be based on … …American Journal of Environmental Sciences, Vol. 5, Issue 3 · 30 Jun 2009 · 6,654 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleCocaine Exposure Results in Formation of Dendritic Varicosity in Rat Primary Hippocampal NeuronsHonghong Yao, Crystal Bethel-Brown, Anil Kumar, Shilpa BuchProblem statement: It has been well documented that drugs of abuse such as cocaine can cause enhanced progression of HIV-Associated Neuropathological Disorders (HAND), the underlying mechanisms mediating these effects remain poorly understood. Approach: In present study, we explored the impact of cocaine exposure (I and 10 μM) on the dendritic beading in rat primary hippocampal neurons. Using the approach of … …American Journal of Infectious Diseases, Vol. 5, Issue 1 · 31 Mar 2009 · 7,889 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titlePassive Transfer of HIV-1 Antibodies and Drug Resistant Virus during a Health Care Worker Accident: Implications for HCW Post-Exposure ManagementCarlos Fernando De Oliveira, Ricardo Sobhie Diaz, Abdallah Harmache et al.Problem statement: We studied in detail a case in which a nurse caring for an HIV-infected child suffered a deep-laceration accident with contaminated blood. Approach: The patient had been treated with zidovudine (ZDV) and the nurse became infected despite prophylactic use of ZDV initiated 2 h after the accident. A reactive anti-HIV-1/2 EIA and an indeterminate western blot (gp120/160 reactivity) … …American Journal of Infectious Diseases, Vol. 4, Issue 4 · 31 Dec 2008 · 6,872 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleEffect of Exposure to Various Durations of Light on Serum Insulin-Like Growth Factor-I in Prepubertal Holstein HeifersL.J. Spicer, B.A. Buchanan, L.T. Chapin, H.A. TuckerOur objective was to determine if prolonged exposure to various durations of light (i.e., photoperiod) would affect serum IGF-I concentrations in heifers. Thus, 16 Holstein heifers, 2 to 4 mo of age, were exposed during a 5-wk pretreatment period to 12 h of cool-white fluorescent light (L) at an intensity of 1200 lux and 12 h of dark (D). At … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 2 · 30 Dec 2007 · 6,670 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleHigh Concentrations of Glucose can Activate or Inhibit Human Erythrocyte Aminolevulinate Dehydratase in vitro Depending Exposure TimeJ. C. Soares, D. Gabriel, V. Folmer et al.Hyperglycemia can cause oxidative stress and inactivate susceptible enzymes. In the present investigation we examined whether short-term incubations (24 or 48 h) with high concentrations of glucose (10-200 mmol L-1) inhibit ALA-D from human erythrocytes. Incubations of erythrocytes for 24 h with glucose (10 up to 40 mmol L-1) resulted in an increase of δ-ALA-D activity (P<0,001). Incubations of erythrocytes … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,686 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleExogenous Re-infection by Multiple Exposures to Mycobacterium tuberculosis Contributes to Subsequent Development of Active TuberculosisDiane J. Ordway, Miguel Viveiros, Fernando A. Ventura et al.The majority of tuberculosis (TB) exists in the world’s poorest countries, where costly biosafety level three facilities for containment of infectious TB patients and diagnostic facilities are not affordable. Health care workers (HCWs), in countries with high burdens of tuberculosis (TB) are at risk of nosocomially acquired TB, as there are increased numbers of cases of TB on open hospital … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,967 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleFSH Receptor and Ki-67 Protein Expressions of Endometrial Macaque in Mid-Luteal Phase after Exposure to Various Doses of Recombinant FSH and Fixed-Dose of GnRH AgonistNurhuda Sahar, Ponco Birowo, Rosalina Thuffi et al.There are many advances in Assisted Reproductive Technologies (ARTs). However, implantation rates are still low. The embryo implantation is a mutual interaction between the blastocyst and endometrium. This study aimed to investigate the endometrial cell proliferation stimulated by recombinant Follicle-Stimulating Hormone (rFSH) in various doses by looking at FSH-Receptor (FSHR) and Ki-67 protein expressions. The studied samples were Stored Biological … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 28 May 2021 · 6,347 accessesView PDF Cite

CorrigendumOpen accessEvery word in the titleCorrigendum: Cocaine Exposure Results in Formation of Dendritic Varicosity in Rat Primary Hippocampal NeuronsHonghong Yao, Crystal Bethel-Brown, Shilpa BuchCorrection to: American Journal of Infectious Diseases http://doi.org/10.3844/ajidsp.2009.26.30, published online 2009; updated 08 February 2021 The authors have recently noticed that the representative image of MAP2 immunostaining in the control group in Figure 3A was incorrectly chosen. This error was inadvertently caused during the assembly of the images due to our negligence in the process of reformatting our manuscript. Original … …American Journal of Infectious Diseases, Vol. 17, Issue 1 · 8 Feb 2021 · 6,416 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleGenotoxicity through Exposure to Particulate Matter (PM10) at two Sites in the Valle de Aburrá, ColombiaVerónica Estrada-Vélez, Lucelly López-López, Lina María Martínez-Sánchez et al.To establish differences in the genotoxic effect of particulate matter (PM10) in exposed individuals at two sites in the Valle de Aburrá (VA). This was a descriptive cross-sectional study of 2 groups of individuals exposed to 67.7 and 45 µg/m3 of PM10 for a minimum of 8 hours/day. The frequency of Chromosomal Abnormalities (CAs) and the mitotic index were evaluated … …OnLine Journal of Biological Sciences, Vol. 19, Issue 1 · 19 Mar 2019 · 8,368 accessesView PDF Cite