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197 results for “Tumor”
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Research ArticleOpen accessEvery word in the titleThe Tumor/Immune Interface: Clinical Evidence of Cancer Immunosurveillance, Immunoediting and ImmunosubversionMatthew S. Block, Svetomir N. MarkovicProblem statement: The interactions of a malignant tumor with the patient’s immune system are dynamic, multiple and bi-directional. Approach: This article reviews the clinical evidence of the interaction of cancer with immunity with emphasis on recent developments highlighting some of the mechanisms of tumor-mediated regulation of immunity. Results: Most of the time, the immune response to a malignancy acts to … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 10,095 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMutations in Tumor suppressor TP53 Gene in Formalin- Fixed, Paraffin Embedded Tissues of Squamous Cell Carcinoma (SCC) of Lung CancerAbbas Mohammadi, Ali Vaziri Gohar, Mohamad Reza ShakibaieThe TP53 gene mutations have been extensively studied in lung cancer and have been used as a means to understand the origin(s) and mechanisms of these mutations in lung cancer development. TP53 gene mutations occur frequently in many human cancers. Analysis of TP53 gene mutations can also provide clues to the etiology of tumor formation. Formalin-fixed, paraffin embedded (FFPE) tissues … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 1 · 31 Mar 2008 · 8,000 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA Two Dimensional Infinite Element Model to Study Temperature Distribution in Human Dermal Regions due to TumorsK. R. pardasani, Madhvi shakyaIn this study, a two dimensional infinite element model has been developed to study thermal effect in human dermal regions due to tumors. This model incorporates the effect of blood mass flow rate, metabolic heat generation and thermal conductivity of the tissues.The dermal region is divided into three natural layers, namely, epidermis, dermis and subdermal tissues. A uniformly perfused tumor … …Journal of Mathematics and Statistics, Vol. 1, Issue 3 · 30 Sep 2005 · 6,372 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Interplay between p53 and p21 Tumor Suppressor Proteins in the Transformation of Colorectal Adenoma to CarcinomaA.S. Abdulamir, R.R. Hafidh, L.K. Mahdi et al.This study was carried out for evaluating the interplay of p53, p21 and Ki-67 proteins along the colorectal adenoma-carcinoma oncogenic transformation sequel. Therefore, Fifty colorectal cancer and 14 adenoma patients were involved. The histopathological expression of p53, p21 and Ki-67 proteins was evaluated by immunohistochemistry assay. The results revealed that remarkable overexpression of p53 protein was seen in the tumorous … …American Journal of Immunology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,740 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSensitivities of Uterine Adenocarcinoma, Mixed Mullerian Tumor (MMT) and Sarcoma Cell Lines to Chemotherapeutic Agents and a Flex-Het DrugJohnny Hyde, Doris M. BenbrookThe administration and combination of a variety of chemotherapeutic agents for treatment of advanced or recurrent uterine cancer of different histologies is under current debate. Mixed Mullerian Tumors (MMTs), which contain both adenocarcinoma and sarcoma components, are the most rate histologic type and it is therefore difficult to conduct clinical trials to determine if they should be treated like endometrial … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,460 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleImatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma MembraneHans Prenen, Cristiana Stefan, Bart Landuyt et al.Imatinib mesylate, the inhibitor of the KIT protein tyrosine kinase that is constitutively activated in Gastrointestinal Stromal Tumors (GISTs), has been established as the first highly effective drug in the treatment of patients with advanced GISTs. Recent studies suggest that changes in the glucose metabolism could be an additional mechanism of the anti-proliferative action of imatinib. The aim of this … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,245 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleQuantitative Analysis of Hypothalamic Proline-Rich Peptide-1 in Blood Serum of Patients with Malignant TumorsNarine Tumasyan, Silva Abrahamyan, Nune Kocharyan et al.The proline-rich-peptides are a class of neurosecretory hypothalamic bioactive polypeptides derived from cattle and comprise the content of bovine posterior pituitary neurosecretory granules. These peptides are co-validated through a single precursor protein neurophysin-vasopressin-associated glycoprotein. Proline-Rich-Polypeptide-1 (PRP-1) is a 15-amino acid peptide with anti-neurodegenerative, immunoregulatory, hematopoietic, antimicrobial, and antitumor activity. The aim of this study, accordingly, is to elaborate an assay … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 27 Nov 2025 · 2,283 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleImpact and Control of Drug Therapy Guidelines for Tumor Patients During the Novel Coronavirus Pneumonia EpidemicRazi Ahmed, Shafiza Mohd Shariff, Shahrinaz Ismail et al.Since December 2019, many unexplained viral pneumonia cases have been found in Wuhan City, Hubei Province, China. It was later confirmed that the outbreak's causative agent was a new coronavirus. The virus was temporarily named "2019-new coronavirus" (2019-nCoV) by the World Health Organization (WHO). The diseases caused by 2019-nCoV were called by the National Health and Health Commission of China … …Journal of Computer Science, Vol. 17, Issue 8 · 9 Sep 2021 · 6,683 accessesView PDFCite
Case ReportOpen accessEvery word in the titleRetroperitoneal Hydatid Cyst Masquerading as a Retroperitoneal Cystic TumorK. Hemanth Kumar, Anish Choudhary, Amaresh Aruni, N.V.K.N. KarthikHydatid disease is an endemic disease, with canines the primary host and humans the intermediate host. Liver, spleen and lungs are most common involved organs, but it can involve any organ. Retroperitoneal hydatid cyst are categorised into two types, primary and secondary. Primary retroperitoneal hydatid cyst is rare disease, with most of the cases diagnosed intra-operatively, hence pre-operative high index … …American Journal of Infectious Diseases, Vol. 15, Issue 3 · 29 Aug 2019 · 7,266 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleClassification of Breast Tumor in Mammogram Images Using Unsupervised Feature LearningAidarus M. Ibrahim, Baharum Baharudin, Abas Md Said, P. N. HashimahIn this study, we propose a learning-based approach using feature learning to minimize the manual effort required to extract features. Firstly, we extracted features from equally spaced sub-patches covering the input Region of Interest (ROI). The dimensionality of the extracted features is reduced using max-pooling. Furthermore, spherical k-means clustering coupled with max pooling (k-means-max pooling) is compared with well-known feature … …American Journal of Applied Sciences, Vol. 13, Issue 5 · 13 May 2016 · 7,497 accessesView PDFCite