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192 results for “Pathway”
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Review ArticleOpen accessIn the keywordsMicroRNA-92a: The Administrator of Certain DiseasesZhiyuan Sun, Qing Xu, Xiaoyi Tian et al.MicroRNA-92a (miR-92a) is an evolutionarily conserved noncoding small RNA that can regulate gene expression after transcription. Previous studies have found that miR-92a is overexpressed in many tumors and can regulate numerous tumor suppressor genes negatively, with relevant effects on the development of different tumors, by regulating the DUSP10/c-Jun N-terminal kinase (JNK), phosphatase and tensin homologs (PTEN)/AKT, Wnt and EP4/Notch1 signaling … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 21 May 2020 · 6,494 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIn silico Analysis of three Committed-Steps Involved in Triterpenoid Biosynthesis from Ganoderma lucidumXiaorong Shui, Xiaozhong Lan, Wei LeiGanoderma lucidum is widely considered as one of the most valuable Traditional Chinese Medicines, with various bioactive constituents and pharmaceutical effects. Triterpenoids are important effective ingredients of G. lucidum, which are synthesized mainly through the mevalonate pathway. In this study, we aimed to characterize and analyze three committed-step enzymes of the mevalonate pathway, 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGR), Farnesyl Diphosphate Synthase … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 3 · 15 Aug 2016 · 7,347 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffects of Unilateral Cervical Vagotomy on Murine Dendritic CellsDaniel Sanzio Gimenes da Cruz, Ana Paula Nascimento de Lima, Patrícia Benites Gonçalves da Silva et al.The cholinergic anti-inflammatory pathway has been demonstrated to be an important mechanism that modulates several inflammatory diseases. This modulation occurs upon activation of the vagus nerve, which modulates splenic macrophages and lymphocytes through the predominant neurotransmitter, Acetylcholine (ACh). We hypothesized that this modulation could also take place in dendritic cells, as these cells represent a link between the innate and … …American Journal of Immunology, Vol. 11, Issue 2 · 12 Jul 2015 · 6,948 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInduced Production of α-Tocotrienol by Co-Suppression of Tocopherol Cyclase Gene in Vegetable CropsUmaiyal Munusamy, Siti Nor Akmar Abdullah, Maheran Abdul Aziz et al.This study involves the induced production of α-tocotrienol by the co-suppression of tocopherol cyclase gene. The Tocopherol/Tocotrienol Cyclase (TC) is a key enzyme involved in the biosynthesis of α-tocotrienol. The partial conserved cDNA of TC gene isolated from the oil palm (Elaeis guineensis) that shared greater than 75% sequence identity with TC sequences from other plant species was used to … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 4 · 20 Dec 2013 · 7,706 accessesView PDFCite
Review ArticleOpen accessIn the keywordsStrigolactones in Plant Stress Adaptation: Mechanisms and Agricultural PotentialHumayra Ferdus, Mahabuba Mostafa, Md. Motaher HossainAbiotic stresses have significant negative effects on the growth, development, and productivity of crop plants, which are critical to global agricultural production and ecosystem stability. Strigolactones (SLs), a family of carotenoid-derived plant phytohormones, have been identified as playing key roles in plant development and adaptive responses to environmental stimuli. Initially recognized as signaling molecules in host-parasite interactions and as symbiotic … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 3 Oct 2026 · 559 accessesView PDFCite
Review ArticleOpen accessIn the keywordsMicrobial Degradation of Paracetamol in Pharmaceutical Wastewater: A ReviewYahya Seun Yisau, Naeif Hamoud Al-Makishah, Mohamed Abou El-Fetouh BarakatParacetamol (4′-hydroxyacetanilide or N-acetyl-p-aminophenol or Acetaminophen) is an analgesic and antipyretic over-the-counter commonly used drug. Paracetamol has been detected in, surface waters, wastewater, and drinking water globally because of its significant utilization and unregulated release into the surroundings which have been a great concern and require an urgent approach. Microbial degradation of paracetamol is considered a desirable choice because of … …American Journal of Environmental Sciences, Vol. 20, Issue 1 · 3 Aug 2024 · 6,917 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractNanowire Mediated Effect of Interspecies Electron Transfer in Organic Solid Waste Co-FermentationJingkang Chen, Daicheng Liu et al.Low efficiency of Interspecific Electron Transfer (IET) among microorganisms constrains organic matter degradation and biogas production in organic solid waste co‑fermentation. This work investigates the underlying bottleneck and evaluates the nanowire‑mediated enhancement of IET. Surface plasmon resonance‑enhanced electrochemical impedance spectroscopy coupled with metagenomic and metatranscriptomic sequencing was applied to regulate endogenous nanowire formation in anaerobic reactors. Surface Plasmon Resonance-Enhanced Electrochemical … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 9 Oct 2026 · 591 accessesView PDFCite
Review ArticleOpen accessIn the abstractJAK Inhibitors for Rheumatoid Arthritis: Assessing Efficacy and Safety in TreatmentAnastasia V. Poznyak, Varvara A Orekhova, Natalia Vladimirovna Elizova et al.Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, progressive joint destruction, and systemic complications. Dysregulated cytokine signaling through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a central role in RA pathogenesis, making JAK inhibitors an important therapeutic option. Tofacitinib, baricitinib, and upadacitinib are oral targeted synthetic disease-modifying antirheumatic drugs that interfere with … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 8 Oct 2026 · 412 accessesView PDFCite
Research ArticleOpen accessIn the abstractBioethanol Production from Graminoid Weeds in Bayero University Kano: A Potential Feedstock for Future Sustainable Aviation Fuel ApplicationsAdam Salihu Kila, Sa’idu Hassan Musa, Umar Aliyu Ahmed et al.This study evaluates the potential of selected graminoid weeds from Bayero University, Kano (BUK), Nigeria, as feedstock for bioethanol production. Ten (10) abundant weed species, including Cenchrus species, Cynodon dactylon, and Setaria barbata, were subjected to physicochemical pretreatment (ultrasonication, hydrothermal treatment, and enzymatic hydrolysis) followed by fermentation using Bacillus subtilis, Saccharomyces cerevisiae, and their co-culture. Pretreatment significantly enhanced reducing sugar … …Energy Research Journal, Vol. 15, Issue 1 · 15 Jul 2026 · 1,170 accessesView PDFCite