Research ArticleOpen accessIn the abstractThe Role of Treg Cells in the Cancer Immunological ResponseZhi-Zhang Yang, Stephen M. AnsellProblem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 8,518 accessesView PDFCite
Research ArticleOpen accessIn the abstractAbdominal and Thoracic Aortic Aneurysm ModelingMona Abdolrazaghi, Mehdi NavidBakhsh, Kamran HassaniModeling is a beneficial tool for understanding cardiovascular system functioning and pathophysiology of the system. The present study is concerned with left ventricle Pressure-Volume diagrams obtained by modeling of aortic aneurysms using the cardiovascular electronic system. In addition, these graphs were compared with a normal condition. The electrical circuit of the cardiovascular system consists of 42 segments including the main … …American Journal of Applied Sciences, Vol. 5, Issue 8 · 31 Aug 2008 · 6,606 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvidence of Mitochondrial Dysfunction in Autism and Implications for TreatmentDaniel A. Rossignol, J. Jeffrey BradstreetClassical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms. … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 16,373 accessesView PDFCite
Research ArticleOpen accessIn the abstractOxidative Stress in Autism: Elevated Cerebellar 3-nitrotyrosine LevelsElizabeth M. Sajdel-Sulkowska, Boguslaw Lipinski, Herb Windom et al.It has been suggested that oxidative stress and/or mercury compounds play an important role in the pathophysiology of autism. This study compared for the first time the cerebellar levels of the oxidative stress marker 3-nitrotyrosine (3-NT), mercury (Hg) and the antioxidant selenium (Se) levels between control and autistic subjects. Tissue homogenates were prepared in the presence of protease inhibitors from … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 17,119 accessesView PDFCite
Research ArticleOpen accessIn the abstractColourimetric Determination of Phospholipase Activities in Balamuthia mandrillarisSyed Razi HaiderBalamuthia mandrillaris is a recently identified protozoan pathogen that can cause fatal granulomatous encephalitis however the pathogenesis and pathophysiology associated with Balamuthia encephalitis remain unclear. We have recently isolated B. mandrillaris from a 33-years old male who died of encephalitis. Using this isolate, we demonstrated for the first time that B. mandrillaris exhibited phospholipase activities. More specifically, B. mandrillaris exhibited … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 6,771 accessesView PDFCite
Research ArticleOpen accessIn the abstractGranulomatous Amoebic Encephalitis: Clinical Diagnosis and ManagementNaveed Ahmed KhanGranulomatous amoebic encephalitis (GAE) is a serious human disease with fatal consequences. With the mortality rate of more than 90%, it is not surprising that the majority of GAE infections are identified at the post-mortem stage. The most distressing aspect is that the high level of mortality is attributed to lack of awareness. Early diagnosis with aggressive treatment can lead … …American Journal of Infectious Diseases, Vol. 1, Issue 2 · 30 Jun 2005 · 7,187 accessesView PDFCite