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EditorialOpen accessIn the abstractChasing the Fat Demon: Fat Chance, Buddy?David L. Katz, Joachim Storsberg, Christian SchmidtScience is an interesting profession. At times, one could get caught up in his or her own world of thoughts, perception, far away from reality, sometimes referred to as the proverbial ivory tower (Lederberg, 1972). Science for the sake of science is, per se, not without merit, with our fragmented understanding of a given issue providing ample justification for experimentation … …American Journal of Immunology, Vol. 13, Issue 2 · 29 May 2017 · 8,137 accessesView PDFCite
Research ArticleOpen accessIn the abstractPunicalagin Suppresses Mediators Involved in Labor Onset and Progression in vitroCaitlyn Nguyen-Ngo, Jane C Willcox, Martha LappasSpontaneous preterm birth is the leading cause of neonatal morbidity and mortality. Inflammation plays a central role in the activation of myometrial contractions and rupture of fetal membranes associated with spontaneous preterm birth. The pomegranate polyphenol punicalagin is known to possess anti-inflammatory properties. In this study, we aimed to determine the effect of punicalagin on pro-inflammatory and pro-labor mediators in … …American Journal of Immunology, Vol. 17, Issue 1 · 22 Dec 2021 · 7,613 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudies on Pharmacokinetics and Liver Microsome Metabolism of Nuciferine in Different Species of AnimalsDong Xiao-Chen, Liu Ming-Qi, Liu Jun et al.This study aimed to compare the characteristics of pharmacokinetics and liver microsome metabolism among different species of animals including rabbit, rat and mouse and healthy New Zealand white rabbits, SPF Sprague Dawley (SD) rats and ICR mice were given intraperitoneal injection of nuciferine at a dose of 50 mg per kg body weight. Blood samples were collected via caudal vein … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 3 · 12 Aug 2021 · 6,473 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,629 accessesView PDFCite
EditorialOpen accessIn the abstractNeutrophil Extracellular Traps as Therapeutic Targets for Inflammatory DiseaseRory R. KoenenNeutrophilic granulocytes, or neutrophils are the most abundant circulating white blood cell and constitute a first line of defense against pathogens. They are characterized by a large polymorphic lobular nucleus and the presence of many secretory granules in their cytoplasm. Neutrophils are essential for a functional host defense, as is evidenced by the occurrence of severe infections in individuals with … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 25 Feb 2015 · 8,740 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuronal Necrosis Due to a Lethal Epileptic Syndrome Affecting FVB Strain β-Actin Luciferase Transgenic MiceAhmed Shoieb, Rachel Allavena, Abdelazim IbrahimThe FVB is the most often inbred mouse strain used in transgenic research. This strain is recognised to be affected with a disease known as FVB Lethal Epileptic Syndrome (FLES). A case series of FVB mouse lethal epileptic syndrome in a cohort of commercially procured β actin luciferase transgenic FVB mice was diagnosed based on the clinical signs, post-mortem and … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 10 Dec 2014 · 7,486 accessesView PDFCite
Research ArticleOpen accessIn the abstractMORINGA TEA BLOCKS ACUTE LUNG INFLAMMATION INDUCED BY SWINE CONFINEMENT DUST THROUGH A MECHANISM INVOLVING TNF-α EXPRESSION, C-JUN N-TERMINAL KINASE ACTIVATION AND NEUTROPHIL REGULATIONMykea Mcknight, Jabria Allen, Jenora T. Waterman et al.Plant based products represent a promising alternative to conventional treatments for inflammation. Moringa oleifera Lam is a tree rich in proteins, vitamins, minerals and a variety of phytochemcals with health benefits. Among the reported health benefits are antioxidant and anti-inflammatory properties. The purpose of this study was to investigate whether tea brewed from dried Moringa leaves would abrogate inflammation in … …American Journal of Immunology, Vol. 10, Issue 2 · 8 May 2014 · 11,603 accessesView PDFCite
Research ArticleOpen accessIn the abstractTHE DYNAMIC NONCE BASED AUTHENTICATION SCHEME TO DEFEND INTERMEDIARY ATTACK FOR WEB SERVICESElangovan Uma, Arputharaj KannanNowadays, Web services have used drastically for various online applications like banking, e-bill processing. All online services need robust security architecture for handling sensitive data like user name, password. But, The Web service has security problems that need to be solved. The existing security scheme lacks to defend the attacks from replay and password guessing attacks. In this study we … …Journal of Computer Science, Vol. 9, Issue 8 · 4 Jul 2013 · 6,855 accessesView PDFCite
Research ArticleOpen accessIn the abstractUsing Bioequivalence Approach to Assess Toxicity Effect of Herbal Products, TyrelTM and RumbionTMChunhao Tu, Woon Yuen KohProblem statement: Herbal products have been widely used in veterinary healthcare. Recently, an experiment was conducted in the Natural Animal Facility Pvt. Ltd., Bangalore, India on ten Albino Wistar female mice to assess the acute oral toxicity of two herbal products, TyrelTM and RumbionTM. However, the researchers did not evaluate the toxicity effect of the two products in terms of … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,826 accessesView PDFCite
Research ArticleOpen accessIn the abstractInjection Molding of Titanium Alloy Implant For Biomedical Application Using Novel Binder System Based on Palm Oil DerivativesR. Ibrahim, M. Azmirruddin, M. Jabir et al.Problem statement: Titanium alloy (Ti6Al4V) has been widely used as an implant for biomedical application. In this study, the implant had been fabricated using high technology of Powder Injection Molding (PIM) process due to the cost effective technique for producing small, complex and precision parts in high volume compared with conventional method through machining. Approach: Through PIM, the binder system … …American Journal of Applied Sciences, Vol. 7, Issue 6 · 30 Jun 2010 · 8,520 accessesView PDFCite