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49 articles for “Molecular Interactions”
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Research ArticleOpen accessIn the abstractHOMOLOGY MODELING AND MOLECULAR DYNAMICS STUDIES OF EC1 DOMAIN OF VE-CADHERIN TO ELUCIDATE DOCKING INTERACTION WITH CADHERIN-DERIVED PEPTIDEVivitri Dewi Prasasty, Usman Sumo Friend Tambunan, Teruna Jaya SiahaanVE-cadherin is a protein in the cadherin family that is found at the adherens junctions of the microvessel endothelial cells of the Blood-Brain Barrier (BBB). It is recognized as the homotypic cell adhesion molecules and there is limited structural information on how VE-cadherins mediate cell-cell adhesion. It has been shown that the EC1 domain of cadherins is important for the … …OnLine Journal of Biological Sciences, Vol. 14, Issue 2 · 25 Jun 2014 · 7,534 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Silico and in Vitro Studies: Tryparedoxin Peroxidase Inhibitor Activity of Methotrexate for Antileishmanial ActivityRavi Kumar Gundampati, Shraddha Sahu, Avinash Kumar Srivastava et al.In order to understand the mechanism of molecular interactions at the active site of Tryparedoxin Peroxidase (Try P), homology modeling and docking studies were performed. We generated a Three-Dimensional (3D) model of target protein based on the Crystal structure of Leishmania Major Try PI (PDB ID: 3TUE) using modeler software. Docking analysis was carried out to study the effects of … …American Journal of Infectious Diseases, Vol. 9, Issue 4 · 28 Nov 2013 · 7,894 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Pharmacological Targets Combining Docking and Molecular Dynamics SimulationsIlizaliturri-Flores Ian, Rosas-Trigueros Jorge Luis, Carrillo-Vazquez Jonathan Pablo et al.Studies that include both experimental data and computational simulations (in silico) have increased in number because the techniques are complementary. In silico methodologies are currently an essential component of drug design; moreover, identification and optimization of the best ligand based on the structures of biomolecules are common scientific challenges. Geometric structural properties of biomolecules explain their behavior and interactions and … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 1 · 21 Mar 2013 · 8,130 accessesView PDFCite
Research ArticleOpen accessIn the abstractAgro-Process Intensification through Synthetic Rhizosphere Media for Nitrogen Fixation and Yield Enhancement in PlantsG. Akay, D. R. BurkeProblem statement: In order to combat global warming and the emerging Food, Energy and Water shortages (FEWs), several approaches have been adopted, including genetic engineering and farming practices. Biomass based energy technology will further stress food and water resources and hence novel holistic approaches to FEWs should be designed. Approach: A novel technique (Agro-Process Intensification, A-PI) which simultaneously addresses FEWs … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 2 · 15 Mar 2012 · 8,603 accessesView PDFCite
Research ArticleOpen accessIn the abstractNutrition in Tertiary Education: Biological and Social ApproachesG. A. Fragkiadakis, C. Papandreou, K. GkouskouProblem statement: Human Nutrition, a necessary component of health-education, studies the food-depended growth/maintenance of the human body. To approach what nutritionists will need to apply in the 21st century, we searched the literature for new syllabus-fields. Approach: We detected fields likely to play a significant and innovative role in university teaching of Human Nutrition; then tried a synthesis of biological … …Journal of Social Sciences, Vol. 8, Issue 2 · 18 Feb 2012 · 8,595 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Dynamics Studies of Human β-GlucuronidaseIbrahim Ali Noorbatcha, Ayesha Masrur Khan, Hamzah Mohd SallehProblem statement: The enzyme β-glucuronidase is being used as a reporter molecule in the area of genetic engineering, as a component of prodrug therapy in cancer treatment and in the scouring process of cotton fabrics. However, a detailed understanding of the factors responsible for the stability and the activity of this enzyme is still not available. Molecular Dynamics (MD) simulations … …American Journal of Applied Sciences, Vol. 7, Issue 6 · 30 Jun 2010 · 7,619 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Widely Used Diagnostics "DNA Microarray"-A ReviewR. Manoj KumarProblem statement: DNA microarray technique is one of the latest advances in the field of molecular biology and medicine. It is a multiplex technique used in combination of bioinformatics and statistical data analysis. Since, 1995, the technique offers the possibility of conducting tens or hundreds of thousands of simultaneous hybridizations. Approach: This increased experimental efficiency permits high throughput and whole … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 7,789 accessesView PDFCite
Research ArticleOpen accessIn the abstractMedical Consequences of Drug Abuse and Co-occurring Infections: A Brief ReviewJag H. KhalsaToday substance abuse remains one of the major problems in the world with millions of people abusing legal and illegal drugs. In addition, almost one-third of the world population of 6.7 billion people may also be infected with one or more infections. Both drugs of abuse and infections are associated with enormous burden of social, economic and health consequences. This … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 6,737 accessesView PDFCite
Research ArticleOpen accessIn the abstractExpression of Thioredoxin-Fusion Proteins of α-Gliadin, γ-Gliadin and Low Molecular Weight Glutenin, from Wheat Endosperm and their Domains in EnterobacteriaClaudia G. Benitez-Cardoza, Yves Popineau, Jacques GueguenWheat seed storage proteins play a determining role in the viscoelastic properties of wheat gluten. The genes encoding α-gliadin, γ-gliadin and Low Molecular Weight glutenin and their N-central-repetitive and C-terminal domains from wheat endosperm had been subcloned into a thioredoxin expression system (pET102/D-Topo) and produced as fusion proteins in E. coli. The expression levels for each of the proteins varied … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 6,748 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Study of Morphological Structure, Phase Structure and Molecular Structure of Collagen-PEO 600K Blends for Tissue Engineering ApplicationN. F. Mohd Nasir, M. G. Raha, N. A. Kadri et al.A new material which is collagen/ poly (ethylene oxide) (PEO) blend was developed to determine its possibility as a promising material for tissue scaffold. PEO with average molecular weight of 600,000 and collagen originated from calf skin were dispersed in 0.1 M acetic acid to prepare a concentration of 1 wt% for PEO and 0.15 wt% for collagen. The collagen-PEO600K … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 7,426 accessesView PDFCite