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83 results for “Molecular Interaction”
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EditorialOpen accessIn the abstractAre Heat Shock Proteins Druggable Candidates?Tawanda Zininga, Addmore ShonhaiBanumathy, G., V. Singh, S.R. Pavithra and U. Tatu, 2003. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. J. Biol. Chem., 278: 18336-18345. DOI: 10.1074/jbc.M211309200 Brehmer, D., S. Rudiger, C.S. Gassler, D. Klostermeier and L. Packschies et al., 2001. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nature Structural Molecular … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 2 Dec 2014 · 8,171 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Silico and in Vitro Studies: Tryparedoxin Peroxidase Inhibitor Activity of Methotrexate for Antileishmanial ActivityRavi Kumar Gundampati, Shraddha Sahu, Avinash Kumar Srivastava et al.In order to understand the mechanism of molecular interactions at the active site of Tryparedoxin Peroxidase (Try P), homology modeling and docking studies were performed. We generated a Three-Dimensional (3D) model of target protein based on the Crystal structure of Leishmania Major Try PI (PDB ID: 3TUE) using modeler software. Docking analysis was carried out to study the effects of … …American Journal of Infectious Diseases, Vol. 9, Issue 4 · 28 Nov 2013 · 7,894 accessesView PDFCite
Research ArticleOpen accessIn the abstractStructural Consequences of the Polymorphism Q223R in the Human Leptin Receptor: A Molecular Dynamics StudyJonathan P. Carrillo-Vázquez, Brenda Chimal-Vega, Beatriz Zamora-López et al.Leptin Receptor (LEPR) is a component of a signaling pathway related to appetite and energy expenditure. Single Nucleotide Polymorphisms (SNP) of Leptin receptor gene (lepr) have been proposed as possible modulator of adipose tissue and body weight. The main phenomenological consequence reported of these SNPs is the modulation of the LEP-LEPR interaction promoting the weight gain. Particularly, Q223R polymorphism has … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 3 · 23 Sep 2013 · 7,839 accessesView PDFCite
Research ArticleOpen accessIn the abstractHost Pathogen Interaction Study in Malformed Affected Tissues of Mangifera indica L.Pradeep Kumar, Madhu Kamle, Vijai Kumar Gupta et al.The malformation disease of mango by Fusarium moniliforme var. subglutinan is one of the major causes of huge economical loss every year. Early diagnosis of the pathogens can help cultivators to protect the mango orchid and fruits from successive and secondary infection. The molecular detection is one of the better choices among available techniques for diagnosis. But the farmers or … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 3 · 4 Sep 2013 · 7,922 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Pharmacological Targets Combining Docking and Molecular Dynamics SimulationsIlizaliturri-Flores Ian, Rosas-Trigueros Jorge Luis, Carrillo-Vazquez Jonathan Pablo et al.Studies that include both experimental data and computational simulations (in silico) have increased in number because the techniques are complementary. In silico methodologies are currently an essential component of drug design; moreover, identification and optimization of the best ligand based on the structures of biomolecules are common scientific challenges. Geometric structural properties of biomolecules explain their behavior and interactions and … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 1 · 21 Mar 2013 · 8,130 accessesView PDFCite
Research ArticleOpen accessIn the abstractIN SILICO DESIGN OF THE M2 PROTON CHANNEL INHIBITORS OF H1N1 VIRUSUsman Sumo Friend Tambunan, Mochamad Reza Rahdiansyah, Arli Aditya ParikesitM2 proton channel of H1N1 Influenza A virus is the target protein anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The resistance of influenza A virus to amantadine need to develop more effective adamantane-based drugs. Several research by molecular docking method have been … …OnLine Journal of Biological Sciences, Vol. 13, Issue 1 · 5 Jan 2013 · 8,002 accessesView PDFCite
Research ArticleOpen accessIn the abstractInnate, Adaptive and Intrinsic Immunity in Human Immunodeficiency Virus InfectionSuneth S. Perera, Nitin K. SaksenaThe first line of defence of the innate immune system functions by recognizing highly conserved sets of molecular structures specific to the microbes, termed pathogen-associated molecular patterns, or PAMPs via the germ line-encoded receptors Pattern-Recognition Receptors (PRRs). In addition to the innate immune system, the vertebrates have also evolved a second line of defence termed adaptive immune system, which uses … …American Journal of Infectious Diseases, Vol. 8, Issue 3 · 27 Nov 2012 · 9,727 accessesView PDFCite
Research ArticleOpen accessIn the abstractNutrition in Tertiary Education: Biological and Social ApproachesG. A. Fragkiadakis, C. Papandreou, K. GkouskouProblem statement: Human Nutrition, a necessary component of health-education, studies the food-depended growth/maintenance of the human body. To approach what nutritionists will need to apply in the 21st century, we searched the literature for new syllabus-fields. Approach: We detected fields likely to play a significant and innovative role in university teaching of Human Nutrition; then tried a synthesis of biological … …Journal of Social Sciences, Vol. 8, Issue 2 · 18 Feb 2012 · 8,595 accessesView PDFCite