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41 articles for “In vivo Test”
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Research ArticleOpen accessIn the abstractFormulation and Evaluation of a Novel Needle-Free Hepatitis B Surface Antigen Delivery SystemC. D. Licy, K. Premalatha, Annie Shirwaikar, Arun ShirwaikarProblem statement: Hepatitis B is a major public health problem, killing 1-2 million people annually, despite the introduction of an effective vaccine in 1982. Approximately 400 million persons worldwide have chronic hepatitis B. This is due to problems associated with vaccine delivery, stability and cost. Hence the present challenge in Vaccinology is to develop safer, cheaper and easy-to-deliver forms of … …Current Research in Medicine, Vol. 1, Issue 2 · 30 Oct 2010 · 6,819 accessesView PDFCite
Research ArticleOpen accessIn the abstractModulation of Aging in Yeast Saccharomyces cerevisiae by Roselle Petal Extract (Hibiscus sabdariffa L.)Sarima, Rika Indri Astuti, Anja MeryandiniCellular aging drives diseases. Free radicals are called the main cause of cellular aging. Antioxidants can protect the body from free radical attack by reducing its negative effects. An antioxidant source can be obtained from plants, such as roselle (Hibiscus sabdariffa. L). This research was conducted to analyze the ability of roselle petals extract to increase the life span of … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 1 · 6 Apr 2019 · 9,646 accessesView PDFCite
Research ArticleOpen accessIn the abstractHybrid Ceramo-Polymeric Nanocomposite for Biomimetic Scaffolds Design and PreparationRaffaella Aversa, Relly Victoria V. Petrescu, Roberto Sorrentino et al.Biomimetics, biomechanics and tissue engineering are three multidisciplinary fields that have been contemplated in this research to attain the objective of improving prosthetic implants reliability. Since testing and mathematical methods are closely interlaced, a promising approach seemed to be the combination of in vitro and in vivo experiments with computer simulations (in silico). An innovative biomimetics and biomechanics approach and … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 30 Nov 2016 · 8,269 accessesView PDFCite
Research ArticleOpen accessIn the abstractCOMPARATIVE STUDY OF ANTIBACTERIAL ACTIVITY OF PLANT EXTRACTS FROM SEVERAL REGIONS OF ASIAAwatif Al-Judaibi, Ashwag Al-Zahrani, Khadijah A. Altammar et al.This study was designed to investigate the antibacterial activities of alcohol extracts of Phoenix dactylifera (date palm ’type Ajwa’), Nigella sativa (black cumin), Elettaria cardamomum (cardamom), Tinospora crispa (Akar patawali) and Panax ginseng (ginseng). The plant extracts were prepared with methanol and assayed for antibacterial activity against Methicillin-Resistant Staphylococcus Aureus (MRSA) and S. aureus. Extracts of N. sativa, E. cardamomum … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 2 · 2 Apr 2014 · 7,569 accessesView PDFCite
Research ArticleOpen accessIn the abstractPHENOTYPING, VIRULENCE CHARACTERISTICS OF AEROMONAS SPECIES AND THE EFFECTS OF ESSENTIAL PLANT OILS AS ANTIMICROBIAL AGENTS AGAINST PATHOGENIC ISOLATES FROM DIFFERENT SOURCESAhmed M.A. Mansour, Hoda M. Zaki, Nibal A. Hassan, Nihad A.M. El-NasharAeromonas species are increasingly recognized as enteric pathogens. Faecal samples from 20 cow, 45 sheep; 60 goat and 60 camels were examined for the presence of Aeromonas species, which was also sought in the available drinking water (55 well water and 52 drinking chlorinated tap water were also examined). Aeromonas species was isolated more frequently from goats (21.7%) than from … …American Journal of Infectious Diseases, Vol. 10, Issue 1 · 18 Jan 2014 · 8,020 accessesView PDFCite
Research ArticleOpen accessIn the abstractAroclor 1254 Toxicity to Mice Liver Membrane AtpasesShweta Pathak, Rahul KunduPresent communication reports the sub-acute dose and exposure duration dependent effects of Aroclor 1254 on total, Na+, K+, Ca++ and Mg++-ATPases of the mouse liver cells. The study tests two hypotheses, (a) whether the sublethal dose or the exposure duration dependent in vivo exposure of hydrophobic PCB (Aroclor 1254) affects the hydrophilic membrane-bound ion dependent ATPases of the liver cells … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 13 Jul 2013 · 6,791 accessesView PDFCite
Research ArticleOpen accessIn the abstractACUTE TOXICITY STUDY OF TOMATO POMACE EXTRACT IN RODENTSupaporn Muchimapura, Terdthai Tong-Un, Jintanaporn Wattanathorn et al.Tomato and tomato products are considered to be healthy food for the human diet. Although tomatoes have been widely studied for their phenolic content, less emphasize has been laid on toxicological effect of this plant. Thus, the purpose of the present study is to determine the acute toxicity effect of Lycopersicon esculentum, or commonly known as tomato, was administered orally … …OnLine Journal of Biological Sciences, Vol. 13, Issue 1 · 24 Feb 2013 · 7,683 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssessment of Neuropharmacological Activities of Terminalia Chebula in RatsWathita Phachonpai, Jintanaporn Wattanathorn, Terdthai Tong-un et al.Problem statement: Oxidative stress has been implicated in the pathophysiology of many neurodegenerative diseases such as Alzheimer’s Disease (AD). In traditional practices of Ayurvedic medicine, numerous herbs have been used to treat cognitive disorders. Terminalia Chebula (Combretaceae; TC), is a well-known Ayurvedic herbal remedy which possesses an antioxidant activity. The scientific literature strongly supports its in vitro exerted acetylcholinesterase inhibitory … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 11 Jun 2012 · 8,295 accessesView PDFCite
Research ArticleOpen accessIn the abstractDevelopment of Curcumin Based Ophthalmic FormulationD. Anjana, K. Anitha Nair, N. Somashekara et al.Problem statement: Ophthalmic drug delivery system has been a major challenge due to the distinctive and unique anatomy of the eye. The use of phytochemicals for the application in ocular disease has not been investigated much, due to poor pharmacokinetics of phytochemical and hence poor therapeutic efficacy. Approach: Curcumin is one such phytochemical known for its medicinal properties, but its … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 24 Feb 2012 · 15,401 accessesView PDFCite
Research ArticleOpen accessIn the abstractLemon Pepper Fruit Extract (Zanthoxylum acanthopodium DC.) Suppresses the Expression of Inflammatory Mediators in Lipopolysaccharide-Induced Macrophages In VitroYanti, Theodorus Eko Pramudito, Nerissa Nuriasari, Katarina JulianaProblem statement: Lemon pepper fruits (Zanthoxylum acanthopodium DC.; Rutaceae) have been used as a traditional source against stomach ache by Batak people in North Sumatera province, Indonesia. However, its scientific evidence for treatment of inflammatory disorders particularly gastritis has not been reported. Approach: Here, we investigated the inhibitory effects of Lemon Pepper Fruit Extract (LPFE) against inflammatory biomarkers by conducting … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 4 · 14 Feb 2012 · 9,581 accessesView PDFCite