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146 results for “GLUT-2”
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Research ArticleOpen accessIn the keywordsQuercetin in Dimethyl Benzanthracene Induced Breast Cancer in RatsNatla Sashidhar Reddy, Parthasarathy Nirmala, Natesan Chidambaram, Pammi Ashok kumarProblem statement: Vincristine a commonly used anticancer agent in the treatment of breast cancer results in serious adverse effects like teratogenicity, neurotoxicity and carcinogenicity on long term use. Drug resistance is also a common problem encountered with vincristine. Hence the effect of flavonol quercetin, a known antioxidant with no known documented adverse effect was tried in treatment of DMBA induced … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 30 Jul 2012 · 8,138 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPhyllanthus Amarus Facilitates the Recovery of Peripheral Nerve after InjuryPanakpaporn Wannannond, Jintanaporn Wattanathorn, Supaporn Muchimapura et al.Problem statement: Peripheral nerve injuries are associated with morbidity and outcomes of peripheral nerve repair are poor. Moreover, it can subsequently leads to economic or social disability. Recent findings have shown that oxidative stress plays an important role on the functional recovery retardation of peripheral nerve. However, the impairment mentioned earlier is counteracted by antioxidant. Therefore, this study was carried … …American Journal of Applied Sciences, Vol. 9, Issue 7 · 10 May 2012 · 7,098 accessesView PDFCite
Research ArticleOpen accessIn the keywordsUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDFCite
Research ArticleOpen accessIn the keywordsα-Lipoic Acid Therapy Modulates Serum Levels of Some Trace Elements and Antioxidants in Type 2 Diabetic PatientsSalwa Kamal El-Nabarawy, Mona Abd El-Gelel Mohamed, Mohamed Mahmoud Ahmed, Ghada Hany El-ArabiProblem statement: The metabolism of several trace elements has been reported to alter in diabetes mellitus. The disturbance of their serum levels may have a role in the pathogenesis and progress of this disease. In addition, the reports about the status of antioxidants and antioxidant enzymes in diabetic patients are very contradictory. Though α-Lipoic Acid (LA) has long been touted … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 7,762 accessesView PDFCite
Research ArticleOpen accessIn the keywordsTailor-Made Enzyme Carriers: Preparation and Use of Adsorbents Specifically Designed to Immobilize Allosteric Enzymes in Activated ConformationZahra SalemiProblem statement: The enzyme immobilization has experienced substantial growth in the recent past and an ever increasing amount of study has been reported on various aspects of immobilized enzymes. In most of these investigations, catalytic activities are found to be diminished as compared to the enzyme free in solution. Approach: Hydrophobic adsorbents were prepared containing L-leucine or citric acid, two … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,558 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIn vitro and In vivo Antioxidant Activity of Aphanamixis polystachya BarkAlluri V. Krishnaraju, Chirravuri V. Rao, Tayi V.N. Rao et al.Problem statement: Free radical stress leads to tissue injury and progression of disease conditions such as arthritis, hemorrhagic shock, atherosclerosis, diabetes, hepatic injury, aging and ischemia, reperfusion injury of many tissues, gastritis, tumor promotion, neurodegenerative diseases and carcinogenesis. Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. Approach: Many … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 8,734 accessesView PDFCite
Research ArticleOpen accessIn the keywordsA Novel Rodent Model of Autism: Intraventricular Infusions of Propionic Acid Increase Locomotor Activity and Induce Neuroinflammation and Oxidative Stress in Discrete Regions of Adult Rat BrainDerrick F. MacFabe, Karina Rodríguez-Capote, Jennifer E. Hoffman et al.Innate neuroinflammatory changes, increased oxidative stress and disorders of glutathione metabolism may be involved in the pathophysiology of autism spectrum disorders (ASD). Propionic acid (PPA) is a dietary and gut bacterial short chain fatty acid which can produce brain and behavioral changes reminiscent of ASD following intraventricular infusion in rats. Adult Long-Evans rats were given intraventricular infusions of either PPA … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 12,613 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInfluence of Ionizing Radiation on Antioxidant Enzymes in Three Species of TrigonellaMuna M. Al-Rumaih, May M. Al-RumaihThe response of three species of Trigonella, namely, Trigonella stellata, Trigonella hamosa and Trigonella anguina to gamma irradiation stress was investigated with respect to antioxidant enzyme induction. When dry seeds were subjected to gamma rays (0, 40, 60, 80, 100 Krad) from a cobalt source 60Co at a dose rate of 233.5 rad/ min, a dose dependent increase in the … …American Journal of Environmental Sciences, Vol. 4, Issue 2 · 30 Apr 2008 · 8,404 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino RatsAjay k. Gupta, Neelam MisraHepatoprotective activity of aqueous ethanolic extract of Chamomile recutita capitula against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of aqueous ethanolic extract of Chamomile recutita capitula on blood and liver glutathione, Na+ K+- ATPase activity, serum marker enzymes, serum bilirubin, glycogen and thiobarbutiric acid reactive substances against paracetamol induced damage in rats … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 1 · 31 Mar 2006 · 18,946 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntioxidant and Photosynthetic Responses in Plants Under Boron Toxicity: A ReviewLucia Guidi, Alberto Pardossi, Elena Degl’Innocenti, Marco LandiBoron (B) is a micronutrient that has long been known essential not only for plants and animals. Otherwise, in crop plants the range of B concentration from essentiality to toxicity appears extremely narrow. Although B deficiency has been well investigated, during recent years many researchers have also investigated boron toxicity effects, making progress in the comprehension of boron transport within … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 5 Jul 2012 · 12,762 accessesView PDFCite