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54 articles for “Drug Design”
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Research ArticleOpen accessIn the abstractINVESTIGATION OF STABILITY OF KOREAN GINSENG IN HERBAL DRUG PRODUCTLatifa Bashir Babiker, Elrasheed Ahmed Gadkariem, Riyadh Mohammed Alashban, Haya Ibrahim ALjoharThis study was designed to investigate long term stability of K-Gin capsules, a herbal medication that contains korean ginseng. Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. Conducting long term stability studies following the guidelines issued by ICH, WHO and … …American Journal of Applied Sciences, Vol. 11, Issue 1 · 18 Dec 2013 · 9,228 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudies on Emergence of Drug Resistance in HIV Associated Bacterial Urinary Tract InfectionsS. D. Deokar, M. G. BodhankarProblem statement: This study was designed to document the prevalence of HIV associated urinary tract infections in Barshi Tahsil. Such studies had not been researched out before in this region. Approach: The study included samples from 123 HIV reactive and 40 HIV non-reactive patients. In both, mid stream samples were collected and processed to examine for bacterial opportunistic pathogens. The … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 8,472 accessesView PDFCite
Research ArticleOpen accessIn the abstractDevelopment and Optimization of Plant Extract Loaded Nanoemulsion Mixtures for the Treatment of Inflammatory DisorderMukesh Gohel, Tejal Soni, Lal Hingorani et al.In current study, a nanoemulsion as drug delivery system (NE) of spray dried Boswellia Serrata Extract (BSE) was developed and characterized to compare it in vitro/Ex vivo diffusion with reference formulation. Pseudo-ternary phase diagrams were constructed by phase diagram by aqueous titration method, of which the evaluation method was improved for solubility, Droplet size and transmittance. The formulation of BSE-loaded … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 14,068 accessesView PDFCite
Review ArticleOpen accessIn the abstractProtein Sequences Features Extraction for Predicting Beta- Turns and their Types: A ReviewMurtada Khalafallah Elbashir ElfakiBeta-turns are considered to be important secondary structure types that have essential role in molecular recognition, protein folding and stability. They represent 25% of protein structures, therefore they are the most common type of non-repetitive or tight turns structures. Their prediction is considered to be an important issue in bioinformatics and molecular biology, because it provides valuable information and inputs … …Journal of Computer Science, Vol. 15, Issue 9 · 1 Oct 2019 · 7,701 accessesView PDFCite
Research ArticleOpen accessIn the abstractEssential Proteins Discovery Methods based on the Protein-Protein Interaction NetworksLingZhi Zhu, Junling Zhang, Lingya He et al.Essential proteins are closely related to biological survival or reproduction and have important application value in respect of the location of disease genes, disease diagnosis and treatment, drug design. In order to discovery essential proteins, the researchers have proposed experimental approaches, but these methods require laborious and time consuming. With the development of high-throughput sequencing techniques, plenty of computational methods … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 1 Jan 2018 · 8,893 accessesView PDFCite
Research ArticleOpen accessIn the abstractColistin Resistance among Gram Negative Organisms; an Evolving Problem from Tertiary Care Hospital, Pakistan 2014Tuba Bashir, Altaf AhmedThis Study was design to report the evolving Colistin Resistant Gram Negative Organisms from Pakistan in 2014. From 885 isolates of hospitalized patients, 03 Colistin resistant isolates were reported, 02 were Escherichia coli and 01 was Acinetobacter specie. Colistin of all three isolates was tested by Disk diffusion method, MIC by Phoenix 100 (BD) and E-strip. This report contributes a … …Current Research in Microbiology, Vol. 7, Issue 1 · 15 Mar 2016 · 14,728 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigation of Quantitative Plant Activity Relationship (QPAR) for Diabetics II Using Genetic AlgorithmSimanta Kumar Nayak, Bikram Kesari Ratha, Payodhar Padhi et al.The present study demonstrates a novel computational approach for Indian Traditional Medicine (ITM) for the effective antidiabetic drug. Indian traditional practitioners are using many natural Herbals for the cure of diabetes. Though many diabetes patients are getting temporarily cured still its cause and effects are unknown due to lack of proper scientific investigation. Individual plant bioactivities have been already investigated … …Journal of Computer Science, Vol. 11, Issue 3 · 1 Apr 2015 · 6,715 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesign, Synthesis, Biological Screening and Structure Activity Relationship Study of 4, 6-Dimethyl-2-(Substituted) Mercapto-3-(Substituted) Pyridines as Anti Tubercular AgentsMehul M. Patel, Mahesh T. ChhabriyaProblem statement: Tuberculosis is a leading global mortality factor which has not been effectively controlled, with 1.7 million deaths per year and 8.9 million new cases. Aerobic microbe Mycobacterium tuberculosis H37Rv (MTB) is the causative agent of tuberculosis. Although many active antitubercular agents have since been developed, drug resistance will continue to be a problem. Therefore, there is a clear … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,432 accessesView PDFCite
Research ArticleOpen accessIn the abstractBinding Studies of Natural Product Berberine with DNA G-QuadruplexNagendra K. Sharma, Pooja Lunawat, Manjusha DixitProblem statement: The ends of chromosome had highly repetitive short G and C-rich sequences of DNA. These sequences were known to form stable tetraplex type of secondary structures which help to maintain gene integratity after cell divison. Approach: Any reagent which controls the random cell division would be useful to design anticancer drugs. Therefore a many natural and synthesized molecules … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 3 · 22 Sep 2011 · 8,806 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of U6 snRNA Transcription by PTENStephanie Cabarcas, Kounosuke Watabe, Laura SchrammProblem statement: RNA polymerase III (RNA pol III) is responsible for transcribing many of the small structural RNA molecules involved in RNA processing and protein translation, thereby regulating the growth rate of a cell. RNA pol III transcribes both gene internal (tRNA) and gene external (U6 snRNA) promoters and proper initiation by RNA polymerase III requires the transcription initiation factor … …OnLine Journal of Biological Sciences, Vol. 10, Issue 3 · 30 Sep 2010 · 8,557 accessesView PDFCite