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57 results for “Drug Design”
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Research ArticleOpen accessIn the abstractDesigning of Disulfide Cyclic Peptide for Inhibiting Polymerase A and B1 (PAC-PB1N) in H1N1 Virus using Molecular Simulation ApproachUsman Sumo Friend Tambunan, Mochammad Arfin Fardiansyah Nasution, Arli Aditya Parikesit et al.The drug resistance A/H1N1 flu virus is emerging rapidly. Therefore, looking for potential therapy is very important. PB2, PB and PA are subunits of viral RNA-dependent RNA polymerase (RdRp). They play an important role in viral replication. The PA and PB1 binding sites can be considered as potential targets for the development of new influenza drugs. The peptide inhibitors can … …OnLine Journal of Biological Sciences, Vol. 16, Issue 3 · 24 Aug 2016 · 7,310 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalgesic and Anti-inflammatory Activity of Euphorbia antiquorum LinnBanibrata Das, Samina Alam, Rajib Bhattacharjee, Biplab Kumar DasEuphorbia antiquorum (L.) is used as traditional medicine for various ailments in Bangladesh. But the scientific basis for its use especially in pain and inflammation remains largely unknown. Therefore, the present study was designed to evaluate analgesic and anti-inflammatory effect of the aqueous ethanolic extract of the whole plant. The analgesic activity was evaluated by hot plate, acetic acid induced … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 27 Aug 2015 · 9,211 accessesView PDFCite
Research ArticleOpen accessIn the abstractINVESTIGATION OF STABILITY OF KOREAN GINSENG IN HERBAL DRUG PRODUCTLatifa Bashir Babiker, Elrasheed Ahmed Gadkariem, Riyadh Mohammed Alashban, Haya Ibrahim ALjoharThis study was designed to investigate long term stability of K-Gin capsules, a herbal medication that contains korean ginseng. Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. Conducting long term stability studies following the guidelines issued by ICH, WHO and … …American Journal of Applied Sciences, Vol. 11, Issue 1 · 18 Dec 2013 · 9,221 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudies on Emergence of Drug Resistance in HIV Associated Bacterial Urinary Tract InfectionsS. D. Deokar, M. G. BodhankarProblem statement: This study was designed to document the prevalence of HIV associated urinary tract infections in Barshi Tahsil. Such studies had not been researched out before in this region. Approach: The study included samples from 123 HIV reactive and 40 HIV non-reactive patients. In both, mid stream samples were collected and processed to examine for bacterial opportunistic pathogens. The … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 8,468 accessesView PDFCite
Research ArticleOpen accessIn the abstractDevelopment and Optimization of Plant Extract Loaded Nanoemulsion Mixtures for the Treatment of Inflammatory DisorderMukesh Gohel, Tejal Soni, Lal Hingorani et al.In current study, a nanoemulsion as drug delivery system (NE) of spray dried Boswellia Serrata Extract (BSE) was developed and characterized to compare it in vitro/Ex vivo diffusion with reference formulation. Pseudo-ternary phase diagrams were constructed by phase diagram by aqueous titration method, of which the evaluation method was improved for solubility, Droplet size and transmittance. The formulation of BSE-loaded … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 14,064 accessesView PDFCite
Review ArticleOpen accessIn the abstractProtein Sequences Features Extraction for Predicting Beta- Turns and their Types: A ReviewMurtada Khalafallah Elbashir ElfakiBeta-turns are considered to be important secondary structure types that have essential role in molecular recognition, protein folding and stability. They represent 25% of protein structures, therefore they are the most common type of non-repetitive or tight turns structures. Their prediction is considered to be an important issue in bioinformatics and molecular biology, because it provides valuable information and inputs … …Journal of Computer Science, Vol. 15, Issue 9 · 1 Oct 2019 · 7,694 accessesView PDFCite
Research ArticleOpen accessIn the abstractEssential Proteins Discovery Methods based on the Protein-Protein Interaction NetworksLingZhi Zhu, Junling Zhang, Lingya He et al.Essential proteins are closely related to biological survival or reproduction and have important application value in respect of the location of disease genes, disease diagnosis and treatment, drug design. In order to discovery essential proteins, the researchers have proposed experimental approaches, but these methods require laborious and time consuming. With the development of high-throughput sequencing techniques, plenty of computational methods … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 1 Jan 2018 · 8,891 accessesView PDFCite
Research ArticleOpen accessIn the abstractColistin Resistance among Gram Negative Organisms; an Evolving Problem from Tertiary Care Hospital, Pakistan 2014Tuba Bashir, Altaf AhmedThis Study was design to report the evolving Colistin Resistant Gram Negative Organisms from Pakistan in 2014. From 885 isolates of hospitalized patients, 03 Colistin resistant isolates were reported, 02 were Escherichia coli and 01 was Acinetobacter specie. Colistin of all three isolates was tested by Disk diffusion method, MIC by Phoenix 100 (BD) and E-strip. This report contributes a … …Current Research in Microbiology, Vol. 7, Issue 1 · 15 Mar 2016 · 14,722 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigation of Quantitative Plant Activity Relationship (QPAR) for Diabetics II Using Genetic AlgorithmSimanta Kumar Nayak, Bikram Kesari Ratha, Payodhar Padhi et al.The present study demonstrates a novel computational approach for Indian Traditional Medicine (ITM) for the effective antidiabetic drug. Indian traditional practitioners are using many natural Herbals for the cure of diabetes. Though many diabetes patients are getting temporarily cured still its cause and effects are unknown due to lack of proper scientific investigation. Individual plant bioactivities have been already investigated … …Journal of Computer Science, Vol. 11, Issue 3 · 1 Apr 2015 · 6,712 accessesView PDFCite