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75 articles for “Disease Progression”
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EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,657 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparing the Diagnostics Accuracy of CD4+ T-Lymphocyte Count and Percent as a Surrogate Markers of Pediatric HIV DiseaseMusie Ghebremichael, Haben Michael, Jack Tubbs, Elijah PaintsilThe percentage CD4+ T-lymphocytes is used to monitor pediatric HIV disease. However, in resource-limited settings, enumerating the percentage of CD4+ T-lymphocytes is hampered by the lack of laboratory infrastructure and trained technicians. In this paper, we investigated the performances of the percentage and absolute CD4+ T-lymphocytes as markers of pediatric HIV disease progression using data from HIV-infected children enrolled through … …Journal of Mathematics and Statistics, Vol. 15, Issue 1 · 3 Apr 2019 · 7,521 accessesView PDFCite
Research ArticleOpen accessIn the abstractHigh-Dose Vitamin D3 Intake Is Associated with Decreased Symptoms of Multiple SclerosisMichelle L. Steinwart, David M. DuriancikMultiple sclerosis (MS) is one of the most widespread disabling autoimmune neurological conditions of adults between the ages of 20 and 40 globally. Medical researchers do not completely understand the possible causes of MS, nor have they determined the rate of progression. A limited number of clinical trials conducted in recent years have explored the link between vitamin D deficiency … …American Journal of Immunology, Vol. 14, Issue 1 · 4 Sep 2018 · 9,283 accessesView PDFCite
Literature ReviewOpen accessIn the abstractEfficient Morphometric Techniques in Alzheimer’s Disease Detection: Survey and ToolsVinutha N., P. Deepa Shenoy, K.R. VenugopalThe development of advance techniques in the multiple fields such as image processing, data mining and machine learning are required for the early detection of Alzheimer’s Disease (AD) and to prevent the progression of the disease to the later stages. The longitudinal and cross sectional images of elderly subjects were obtained from the standard datasets like ADNI, OASIS, MIRIAD and … …Neuroscience International, Vol. 7, Issue 2 · 4 Oct 2017 · 8,450 accessesView PDFCite
EditorialOpen accessIn the abstractChasing the Fat Demon: Fat Chance, Buddy?David L. Katz, Joachim Storsberg, Christian SchmidtScience is an interesting profession. At times, one could get caught up in his or her own world of thoughts, perception, far away from reality, sometimes referred to as the proverbial ivory tower (Lederberg, 1972). Science for the sake of science is, per se, not without merit, with our fragmented understanding of a given issue providing ample justification for experimentation … …American Journal of Immunology, Vol. 13, Issue 2 · 29 May 2017 · 8,134 accessesView PDFCite
EditorialOpen accessIn the abstractBig Data and Parkinson’s Disease - from Understanding of Disease to Personalised MedicineYen F. Tai, Nicola PaveseThe advancement of information technology in recent years has generated a huge amount of datasets in all areas of scientific research. This has led to new opportunities to harness the 'Big Data' to improve our understanding of diseases - from investigating disease mechanisms to monitoring treatment responses. The Big Data approach is a data-driven and often hypothesis-free, way of studying … …Neuroscience International, Vol. 7, Issue 1 · 27 Jul 2016 · 7,755 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntibody Responses to HIV-1 gp120 Hypervariable Regions in Six Long-Term Non-ProgressorsRebecca Rivera, Kyung Hee Kang, Murray B. Gardner et al.Our long-term goal is to discover the combination of host parameters that help some HIV-infected individuals to resist progression to AIDS. In this study, we examined antibody responses using multiple samples obtained from a cohort of Long-Term Non-Progressors (LTNPs). Our hypothesis is that antibody responses to variable regions of the HIV-1 envelope glycoprotein are involved in reducing the viral load … …American Journal of Infectious Diseases, Vol. 12, Issue 2 · 1 Jul 2016 · 7,649 accessesView PDFCite
Review ArticleOpen accessIn the abstractRole of Cytokines and Transcription Factors in Periodontitis: A Review of Cellular and Molecular MechanismsAnne Carolina Eleutério Leite, Valéria Martins de Araújo Carneiro, Júlia Faria Nunes et al.Periodontal Diseases (PD) are characterized by pathological manifestation of host immune response to bacterial infection at the tooth/gingival interface. Evidences points periodontitis as a risk factor for pathological systemic conditions, such as, cardiovascular diseases and diabetes. The identification of host factors that determine their susceptibility to immune subversion can provide useful information in the pathogenesis of periodontitis. Protective acute inflammatory … …American Journal of Immunology, Vol. 11, Issue 4 · 9 Dec 2015 · 7,807 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Participation of Oxidative Stress in Breast Cancer Cells Progression and Treatment ResistancePoliana Camila Marinello, Kaliana Larissa Machado, Rubens Cecchini, Alessandra Lourenço CecchiniThis article presents a general discussion about the participation of oxidative stress in relevant points related to breast cancer progression in vitro. All of the evidences presented here are based on published papers that used breast cancer cells with different phenotype characteristics in their research. We observed that oxidative stress could modulate by several manners the tumor progression and these … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 7,511 accessesView PDFCite