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84 results for “Cytotoxic”
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Research ArticleOpen accessIn the keywordsPharmacological Screening of Arceuthobium oxycedri (Dwarf Mistletoe) of Juniper Forest of PakistanMudassir Asrar Zaidi, Ahsan Huda, Sidney A. CrowThe local population of Balochistan, Pakistan considers the Juniperus excelsa an important medicinal plant. The species is facing a grave threat by a parasitic and epiphytic angiosperm, dwarf mistletoe, Arceuthobium oxycedri (DC) M. Bieb (Viscaceae). The methanolic extract of A. oxycedri was studied for its chemical composition and biologically active compounds for the first time. The extract was assayed for … …OnLine Journal of Biological Sciences, Vol. 6, Issue 2 · 31 Dec 2006 · 7,001 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntiproliferative Effects of Alkaloids Isolated from the Tuber of Stephania venosa via the Induction of Cell Cycle Arrest in Mammalian Cancer Cell LinesSirinapa Nantapap, Chatchanok Loetchutinat, Puttinan Meepowpan et al.Problem statement: S. venosa (Menispermaceae) is used in traditional medicine. The constituents of S. venosa belonging to showed remarkable cytotoxic activity. According to previous research, S. venosa contains several alkaloids, such as protoberberine stephanine cyclanoline and N-methylstepholidine, kamaline, (+)-N-carboxamidostepharine, (-)-O-methylstepharinosine, (-)-stepharinosine, aporphine (-)-O-acethylsukhodiamine and oxostephanosine. The chemical and biological investigations of this plant are interesting to bioassay-guided fractionation, particularly Antiproliferative … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,789 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffects of a Cyclachaena Xanthiifolia Extract on Trematodes Opisthorchis Felineus: An in Vitro StudyDenis Ponomarev, Elena Khramova, Natalia Gubanova et al.Cyclachaena xanthiifolia is a phytochemically rich invasive weed with documented allelopathic properties, making it a candidate source of bioactive compounds with potential medicinal applications. This study investigated the anthelmintic activity of a crude aqueous-ethanolic extract of C. xanthiifolia (CxEt), prepared from equal proportions of leaves and seeds, against the trematode Opisthorchis felineus in vitro. The effects of CxEt on the … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 1 Jun 2026 · 1,251 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntiproliferative Potential of Pomegranate Peel Extract in MDA-MB Breast Cancer Cell LinesManal Asif Hamdulay, Fatema Yusuf Singaporewala, Grisilda Vidya Bernhardt et al.Nutraceuticals have gained recognition as adjuvant therapies in cancer treatment due to their non-toxic and protective properties. Among various natural products, pomegranate peel with high antioxidant capacity and rich polyphenol content suggest potential anticancer properties. Previous studies have shown promising anticancer effects of other parts of the pomegranate. The purpose of this research is to compare the effectiveness of Pomegranate … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 1 · 13 May 2025 · 5,582 accessesView PDFCite
Research ArticleOpen accessIn the keywordsFunctional Evaluation of Polydioxanone Threads Coated with Polyethylene Glycol and Amino Acids for Medical ApplicationEunji Park, Tae Su Jang, Jae Kyung KimPolydioxanone (PDO) is a biodegradable polymer with multiple medical applications. Recently, various coatings have been applied to products made of biodegradable polymers, in order to improve functionality. Polyethylene Glycol (PEG) hydrogels have demonstrated remarkable potential in accelerating wound healing and amino acids have been reported to stimulate protein synthesis in vivo and in vitro. The purpose of this study was … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 2 · 24 May 2024 · 5,599 accessesView PDFCite
Research ArticleOpen accessIn the keywordsResponses of Neural Cells (U87) to HCoV-229E and HCoV-OC43 InfectionsEun Ju Oh, Jae-Sik Jeon, Qian-Wen Wang, Jae Kyung KimRespiratory viruses, such as Coronaviruses (CoVs), can be neuroinvasive and exacerbate neurological pathologies via their capacity for direct viral replication and/or by inducing excessive host immune responses in the Central Nervous System (CNS). HCoV-229E is a primary COVID-19 and HCoV-OC43 is a beta COVID-19 belonging to the same genus as SARS-CoV-2 and both can cause acute infections in glioblastoma, neuroblastoma, … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 2 · 8 Jun 2023 · 5,181 accessesView PDFCite
Literature ReviewOpen accessIn the keywordsOptimization of Extraction of Cannabinoids and Flavonoids Substances from Influence Cannabis sp. and their Biological Activities before and after DecarboxylationOlga Kronusová, Michala Piklová, Kristýna Šírová et al.Inflorescence of eight different varieties of Cannabis sp. (3 hemp varieties and 5 medical cannabis varieties) were subjected to extraction with n-hexane or ethanol as representatives of non-polar and polar solvents. Crude extracts were either used directly or after decarboxylation of cannabis acids for measurement of selected biological activities-cytotoxicity against carcinogenic line B16 (musculus skin melanoma cells), cytotoxicity against Human … …American Journal of Applied Sciences, Vol. 19, Issue 1 · 26 May 2022 · 6,735 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIN VITRO TESTING OF MODIFIED COLLAGEN/ HYALURONAN/BETA-GLUCAN SCAFFOLDJan Vojtassak, Dusan Bakos, Martin Bohac et al.Cells and scaffolds belong to main components of tissue engineering. In this study we have performed in vitro cytotoxicity and biocompatibility testing of modified collagen/hyaluronan/beta-glucan scaffold. We used direct contact assay as well as MTT test. Human adipose tissue-derived stem cells were used as biological model. According to obtained results, we can summarize, that modified collagen/hyaluronan/beta-glucan scaffold is non-toxic and … …OnLine Journal of Biological Sciences, Vol. 13, Issue 2 · 12 Jun 2013 · 7,214 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIn Vitro and In Vivo Anticancer Activity of Bacoside A from Whole Plant of Bacopa Monnieiri (Linn)N. S. Prakash, R. Sundaram, S. K. MitraProblem statement: Natural products have long been a fertile source of cure for cancer, which is projected to become the major cause of death in this century. Major classes of anticancer compounds include alkaloids, terpenoids, flavonoids and lignans. We have chosen terpenoids (bacosides) because terpenoids like taxol are currently being used in cancer chemotherapy. The anticancer activity of Bacoside A … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 1 · 7 Jun 2011 · 9,663 accessesView PDFCite
Research ArticleOpen accessIn the keywordsColourimetric Determination of Phospholipase Activities in Balamuthia mandrillarisSyed Razi HaiderBalamuthia mandrillaris is a recently identified protozoan pathogen that can cause fatal granulomatous encephalitis however the pathogenesis and pathophysiology associated with Balamuthia encephalitis remain unclear. We have recently isolated B. mandrillaris from a 33-years old male who died of encephalitis. Using this isolate, we demonstrated for the first time that B. mandrillaris exhibited phospholipase activities. More specifically, B. mandrillaris exhibited … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 6,771 accessesView PDFCite