92 results for “Cytokines”

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Research ArticleOpen accessIn the keywordsThe Effect of Gliflozin Therapy on TNF-α Secretion by Cultured Monocytes in Patients with DiabetesTatiana Vladimirovna Kirichenko, Leyla Azimovna Bochkareva et al.Currently it’s well established that chronic inflammation is a key pathogenetic mechanism in the development of Type 2 diabetes. The study aims to explore the inflammatory response of monocytes in diabetic patients compared to healthy subjects, focusing on TNF-α and to investigate the impact of SGLT2 inhibitors on monocyte inflammation. The study included 20 patients with newly diagnosed type 2 … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 15 Feb 2024 · 4,819 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsPro-Inflammatory Cytokine (IL-1β and IL-6) Response in Goats Challenged with Corynebacterium pseudotuberculosis and its Immunogen Mycolic AcidsFaez Firdaus Jesse Abdullah, Odhah Mohd Naji, Mohd Azmi Mohd Lila et al.The causative agent of Caseous Lymphadenitis (CLA) is Corynebacterium pseudotuberculosis. A chronic disease of sheep and goats which is mainly characterized by suppurative abscesses in both superficial and visceral lymph nodes. There is paucity of information on the proinflammatory cytokine (IL-1β and IL-6) responses due to C. pseudotuberculosis and Mycolic Acid (MAs) inoculation in goats. Therefore, this study was conducted … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 1 · 16 Feb 2017 · 7,790 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsAlterations in Interleukin-1β and Interleukin-6 in Mice Inoculated Through the Oral Routes Using Graded Doses of p. Multocida Type b: 2 and its LipopolysaccharideOmar Suwaidan Ali, Lawan Adamu, Faez Firdaus Jesse Abdullah et al.The gram-negative bacterium Pasteurella multocida serotype B: 2 is an important veterinary and opportunistic human pathogen that causes deplorable welfare problems and colossal economic production losses in bovine and other animal species throughout the world. Pasteurella multocida type B: 2 and its LPS are associated with Haemorrhagic Septicaemia (HS) in mice as animal model. Sixty healthy Balb c mice were … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 1 · 22 Dec 2014 · 7,692 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsSoluble CD14, Sialic Acid and L-Fucose in Breast Milk and their Role in Increasing the Immunity of Breast-Fed InfantsGhalib Ali Oriquat, Tahia H. Saleem, Samir T. Abdullah et al.Problem statement: Breast milk contain protective factors as soluble CD14, L-Fucose and Sialic acid which increase the innate immunity and level of intelligence, decrease the incidence of gastroenteritis, chest and other systemic diseases in newly born infants. In the present study the role of soluble CD14, L-Fucose and Sialic acid, in increasing the immunity in breastfed infants were studied to … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 1 · 27 Apr 2011 · 10,188 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsInduction of a Soluble Anti-HIV-1 factor (s) with IFN-γ, IL-10, and β-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic MixtureJosé W. Rodríguez, Nat O. Pagan, Mar C. Ocasio et al.Partial immune restoration may be obtained with highly active antiretroviral therapy (HAART), but specific anti-HIV-1 immune responses do not appear to improve substantially. We have demonstrated that a soluble factor(s) induced by a mixture of inactivated influenza and bacterial vaccines called polyantigenic immunomodulator (PAI), possesses strong immunoregulatory and anti- HIV-1 activities. In the present study, we show that culture fluids … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 6,845 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsInhibition of Cholesterol Esterification Influences Cytokine Exspression in Lypopolisaccharide-activated P388D1 MacrophagesRosa Rita Bonatesta, Francesca Sanna, Sabrina Uda et al.Several in vivo and in vitro studies have demonstrated the involvement of infectious agents in the development of atherosclerosis. However, the mechanisms by which micro-organisms induce and/or aggravate atherosclerosis, are so far unclear. Accumulation of cholesterol esters and lipid laden cell formation are hallmark of the atherogenesis, however, the possible relationship between cholesterol esterification and the signal-transducing component of LPS … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 7,481 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsIn vitro Activation of Human and Rat Lymphocyte and Macrophage Functions by NorepinephrineRicardo Gomez-Flores, Diana Caballero-Hernandez, Richard J. Weber et al.Norepinephrine (NE) has been associated not only with increasing blood pressure, atherosclerosis, heart disease, and other life threatening conditions, but also with altering immune responses by influencing leukocyte functions. In the present study, we evaluated the in vitro effects of NE on rat thymic lymphocyte and human peripheral blood mononuclear cells (HPBMC) functions. We observed that NE marginally, but significantly … …American Journal of Immunology, Vol. 1, Issue 4 · 31 Dec 2005 · 7,075 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAdipokines Overview: The Major Component of Immune DysregulationAnastasia Vladimirovna Poznyak, Daria Dmitryevna Borodko, Stanislav Anatolievich Antonov et al.Purpose of Review: Obesity is increasingly recognized as an immune endocrine disorder rather than only a metabolic condition. This review critically examines how adipokines particularly adiponectin, resistin, adipsin, and chemerin mediate the interplay between obesity and autoimmunity. Unlike previous reviews that broadly surveyed cytokines, our focus is on comparative roles of specific adipokines across multiple autoimmune diseases. Recent Findings: Evidence … …OnLine Journal of Biological Sciences, Vol. 26, Issue 3 · 11 Aug 2026 · 879 accessesView PDF Cite

Literature ReviewOpen accessIn the abstractUnraveling NETosis: From Immune Mechanisms to Therapeutic InnovationsAnastasia V. Poznyak, Alexey V. Churov, Gulalek Amanmyradovna Babayeva et al.Neutrophil Extracellular Traps (NETs) are integral to immune responses, serving both protective and pathological roles in inflammatory diseases. Despite increasing recognition of NETs, significant gaps remain in understanding the nuanced mechanisms of NETosis and its implications for health and disease. This review systematically explores NETosis—the formation of NETs—by elucidating the molecular signaling pathways and cellular mechanisms involved. We highlight the … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 21 Feb 2026 · 1,678 accessesView PDF Cite

Research ArticleOpen accessIn the abstractExploring the Role of Vitamin B12 as an Anti-atherogenic and Anti-inflammatory Agent in Apparently Healthy Adults With Hypovitaminosis DShravan Ajith Panchwadkar, Sudha Kuthethur, Sowndarya Kollampare, Neelam Manjunath PawarVitamin B12 deficiency is associated with metabolic changes like methyl malonic acidemia and hyperhomocystinemia eventually leading to atherosclerosis. Dyslipidemia and vitamin D (vit D) deficiency are independent risk factors of CVD. This study aims to explore the interrelationship between inflammatory markers, adverse lipid profile and vitamin B12 in hypovitaminosis D. Since, atherosclerosis is an inflammatory condition we have investigated CRP … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 11 Jul 2025 · 3,326 accessesView PDF Cite