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44 articles for “Antibody Response”
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Research ArticleOpen accessIn the abstractUltrastructural and Immunological Characterization of Hepatitis C Core Protein-DNA Plasmid ComplexesNelson Acosta-Rivero, Yaraima Aguilera, Viviana Falcon et al.Recently, it has been shown that a truncated HCV core (HCcAg) variant, covering the first 120 aa (HCcAg.120), interacts with plasmid DNA vaccine (pIDKE2), encoding the HCV structural proteins (HCcAg, E1 and E2). In the present work, HCcAg.120-pIDKE2 complexes, forming heterogeneous packaged structures, were visualized using a negative stain/rotary shadow technique. Interestingly, 72 hours after intramuscular injection of HCcAg.120-pIDKE2 complexes … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,746 accessesView PDFCite
Research ArticleOpen accessIn the abstractPRODUCTION OF CROSS-REACTIVE AUTOANTIBODY BINDING TO BOVINE SERUM ALBUMIN IN THE D-GALACTOSE-INDUCED AGING MOUSE MODELJi-Hun Park, Tae-Saeng ChoiThe D-galactose (D-gal)-induced animal model, generated by repeated subcutaneous D-gal injections over approximately 6 weeks, has been frequently used for diabetes and aging research. However, little research has investigated the direct correlation between D-gal and autoantibody formation despite several reports on diabetes-and aging-related autoantibodies. The purpose of this study was to determine whether repetitive injection of D-gal can induce autoantibody … …American Journal of Immunology, Vol. 10, Issue 1 · 13 Jan 2014 · 7,040 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Proteomics Analysis of Drought Stress-Responsive Proteins as Biomarker for Drought-Tolerant Sugarcane CultivarsNisachon Jangpromma, Supansa Kitthaisong, Khomsorn Lomthaisong et al.Problem statement: The prime objective in breeding selection process of drought-tolerant sugarcane is to identify the correlating marker, which could lead to rapid screening for drought-tolerant cultivars. In this study, we have reported an unknown 18-kDa protein (p18) along with other stress-inducible proteins to be highly expressed in sugarcane leaves under drought stress condition. Approach: The 2D-PAGE patterns of proteins … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 9,819 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunological Evidence for Peptide-Carbohydrate Mimicry with a Group A Streptococcus Polysaccharide-Mimetic PeptideSilvia Borrelli, Rehana B. Hossany, Susan Findlay, B. Mario PintoThe immunogenicity of a peptide-protein conjugate developed by linking a peptide mimic DRPVPY of the Group A Streptococcus cell-wall polysaccharide (GAS-CWPS), to tetanus toxoid (TT) was examined. BALB/c mice were immunized three times subcutaneously following homologous or heterologous prime/boost strategies at 4- or 6- week intervals in two different experiments. DRPVPY-TT, CWPS-TT, heat-killed, pepsin-treated GAS bacteria (with exposed polysaccharide) and … …American Journal of Immunology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,960 accessesView PDFCite
Research ArticleOpen accessIn the abstractDevelopment of Improved Preventive and Treatment Strategies for Controlling of Toxoplasmosis in Saudi ArabiaAlaa B. Ismael, Ayman A. Swelum, Mohammed A. NassanToxoplasmosis causes severe public health problems and has great veterinary and economic importance worldwide. The present study aims mainly to develop an improved preventive and treatment program for controlling toxoplasmosis in sheep and goats. This study was performed on sheep and goats farm containing 357 animals (300 sheep and 57 goats). This farm had a large numbers of barren ewes, … …American Journal of Infectious Diseases, Vol. 12, Issue 2 · 14 Jun 2016 · 7,735 accessesView PDFCite
EditorialOpen accessIn the abstractGLUTATHIONE: A POSSIBLE LINK TO AUTOPHAGY IN SYSTEMIC LUPUS ERYTHEMATOSUSDilip Shah, Swapan K. NathIncreased free radical formation and altered redox state are of fundamental importance in the pathogenesis of autoimmune diseases including Systemic Lupus Erythematos (SLE). Free radicals are mainly derived from oxygen (Reactive Oxygen Species/ROS) and nitrogen (Reactive Nitrogen Species/RNS) at mitochondria, cellular membranes and the endoplasmic reticulum membrane as physiological responses to a variety of internal and external stress (Shah et … …American Journal of Immunology, Vol. 10, Issue 3 · 3 Sep 2014 · 12,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of IL-10 in Urinary Bladder Carcinoma and Bacillus Calmette-Guerin ImmunotherapyYi Luo, Eric J. Askeland, Mark R. Newton, Michael A. O’DonnellProblem statement: Bladder cancer is a common urologic cancer and intravesical Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is the mainstay in the treatment of superficial bladder cancer. However, the current BCG therapy is not desirable with respect to its efficacy and side effects. Interleukin (IL)-10, a T helper type (Th) 2 cytokine, plays an important regulatory role in bladder cancer immunosurveillance … …American Journal of Immunology, Vol. 8, Issue 1 · 9 Mar 2012 · 8,007 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of a DNA Vaccine for Immunocontraceptive Potential Against Zona Pellucida Glycoproteins in CattleC.A. Foley, S.M. Boyle, R.E. Pearson, F.C. GwazdauskasHolstein cows were administered zona pellucida (ZP) DNA vaccine and used to determine the potential of recombinant rabbit ZP glycoproteins (rZP) as immunocontraceptive antigens. Zona pellucida proteins were purified and quantified. Cows were assigned to one of four treatment groups in which plasmids encoding rabbit ZP proteins were administered, i.d., using a gene gun (ZP55, n=2; ZP75, n=2; Hep55, n=2; … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 1 · 31 Mar 2007 · 6,890 accessesView PDFCite
Research ArticleOpen accessIn the abstractLoss of Morphine-induced Suppression of NK Cell activity and T-cell Functions in µ-Opioid Receptor Knockout MiceRichard J. Weber, Ricardo Gomez-Flores, Ichiro Sora, George R. UhlIn vivo administration of µ-opioid receptor selective agonists to various species is known to suppress lymphocyte, NK cell, and macrophage functions, in addition to mediate pain relief and euphoria. Using a mouse model in which the µ-opioid receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in natural killer (NK) cell activity and T … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,941 accessesView PDFCite
Research ArticleOpen accessIn the abstractAndrogen Receptor in Macrophages of Male Rat is Greater Than in FemaleKazem Ahmadi, Alan B. McCrudenThe presence and possible sex differences of androgen receptor in peritoneal macrophages was investigated using immunomagnetic beads. Macrophages were incubated with different concentrations of [3H]-5αDHT in the presence or absence of a 100 fold excess of unlabelled 5α-DHT. Labelled cells were separated from unbound steroid by immunomagnetic beads coated with anti-rat macrophage antibody. The binding identified in the rat macrophages … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,834 accessesView PDFCite