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44 articles for “Animal Models”
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Research ArticleOpen accessIn the abstractIMPACT OF DEHYDROEPIANDROSTERONE IN PREVENTION OF PARACETAMOL INDUCED NEPHROTOXICITY IN RATSAbbas O. ElkaribParacetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. However, Dehydroepiandrosterone (DHEA), the major secretory product of the human adrenal gland, has been shown to possess a multi-targeted antioxidant activity which is also effective against lipid peroxidation induced in various animal models and against various human disorders. In this study, the … …Current Research in Medicine, Vol. 5, Issue 1 · 26 Mar 2014 · 7,568 accessesView PDFCite
Research ArticleOpen accessIn the abstractFlow Cytometry Baseline on Peripheral Leukocyte Cell Profiles for Dairy Goat KidsDarcy M. Fletcher, Megan B. Vogt, Hannah E. Pirner et al.Small ruminants, like goats, would make excellent animal models for not only infectious diseases in large ruminants but also analogous diseases in humans, such as human tuberculosis, Crohn’s disease, melioidosis and brucellosis. The main disadvantage for the small ruminant model is the lack of sufficient baseline data on normal, healthy goat kids. Furthermore, most reagents (antibodies and the like) were … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 4 · 26 Sep 2013 · 7,576 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Vivo Neutralization of Naja nigricollis Venom by Uvaria chamaeOmale James, Ebiloma Unekwuojo Godwin, Idoko Grace OtiniUvaria chamae is a well known medicinal plant in Nigerian traditional medicine for the management of many diseases, but investigations concerning its pharmacological characteristics are rare. In this study, we evaluate its venom neutralizing properties against Naja nigricollis venom in rats. Freshly collected Uvaria chamae leaves were air dried, powdered and extracted in methanol. To study the antivenom properties, albino … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 8,424 accessesView PDFCite
Research ArticleOpen accessIn the abstractClinical and Reproductive Pathological Changes Associated with Brucella melitensis and its Lipopolysaccharides in Female Mice Via Oral InoculationFaez Firdaus Jesse Abdullah, Lawan Adamu, Nur Hazirah et al.Brucella melitensis (B. melitensis) are Gram-negative, aerobic, facultative intracellular bacteria that cause brucellosis that usually leads to abortion in sheep and goats. Three groups of equal number of 24 healthy female mice were used as animal models. They were orally inoculated with 0.4 mL of phosphate Buffered Saline (PBS-Control group), 0.4 mL of 109 cfu of B. melitensis and 0.4 … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 3 · 30 Aug 2013 · 8,576 accessesView PDFCite
Research ArticleOpen accessIn the abstractCancerous Immunoglobulins and CA215: Implications in Cancer ImmunologyGregory LeeImmunoglobulins are typically expressed by B cells in our normal immune system. However, certain normal human tissues, such as hyperplastic epithelial cells, cells of the immunologically privileged sites and the majority of cancer cells, have also been found to be sites of immunoglobulin production. Current research is lacking in regards to the differential immunoglobulin expression, the underling mechanisms of action … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Sep 2012 · 8,946 accessesView PDFCite
Research ArticleOpen accessIn the abstractDietary Fats and Heart Disease: From Prenatal to Postnatal EnvironmentSukhinder K. CheemaProblem statement: Heart disease is the leading cause of death worldwide and is dramatically increasing in developing countries. Preventive approaches, such as dietary and lifestyle changes can have major health implications to prevent the onset of heart disease. Besides healthy nutrition in the adult life, maternal nutrition during pregnancy and lactation can also have a significant impact on the outcome … …Current Research in Medicine, Vol. 3, Issue 2 · 10 Aug 2012 · 7,437 accessesView PDFCite
Research ArticleOpen accessIn the abstractCell-Based Therapies in the Prevention of Solid Organ Transplant RejectionAdrian E. Morelli, Sherrie J. DivitoProblem statement: Organ transplantation is a life-saving and increasingly common procedure, as it often serves as the only treatment available for end-stage organ disease. Although the constant development of new and more effective immunosuppressive drugs has revolutionized the prevention and treatment of acute graft rejection, these drugs have significant toxicity, greatly increase patient susceptibility to neoplasms and infection and exert … …American Journal of Immunology, Vol. 8, Issue 2 · 26 Jul 2012 · 7,418 accessesView PDFCite
Research ArticleOpen accessIn the abstractβ 1, 3-Glucan in Cancer TreatmentVaclav Vetvicka, J. VetvickovaNatural products, useful in preventing and/or treating various diseases, have been sought after throughout the man’s history. Despite some problems inherited from the natural source of glucans, there is extensive literature about their activities in animal tumor models. For the past 25 years, Japan has used several forms of mushroom-derived glucans in treating cancer patients. Additionally, close to twenty clinical … …American Journal of Immunology, Vol. 8, Issue 2 · 6 Jun 2012 · 8,880 accessesView PDFCite
Research ArticleOpen accessIn the abstractLemon Pepper Fruit Extract (Zanthoxylum acanthopodium DC.) Suppresses the Expression of Inflammatory Mediators in Lipopolysaccharide-Induced Macrophages In VitroYanti, Theodorus Eko Pramudito, Nerissa Nuriasari, Katarina JulianaProblem statement: Lemon pepper fruits (Zanthoxylum acanthopodium DC.; Rutaceae) have been used as a traditional source against stomach ache by Batak people in North Sumatera province, Indonesia. However, its scientific evidence for treatment of inflammatory disorders particularly gastritis has not been reported. Approach: Here, we investigated the inhibitory effects of Lemon Pepper Fruit Extract (LPFE) against inflammatory biomarkers by conducting … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 4 · 14 Feb 2012 · 9,587 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic ExtractMarslin Gregory, K. P. Vithalrao, G. Franklin, V. KalaichelavanProblem statement: In spite of being one of the well-known medicinal plants used in Indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of Ficus arnottiana are very scarce. We studied the anti-ulcer activity and acute toxicity of Ficus arnottiana leaf methanolic extract for the first time. Approach: Freshly collected F. arnottiana leaves were dried, powdered … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 9,330 accessesView PDFCite