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359 articles for “Cancer”
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Research ArticleOpen accessIn the abstractMeasure for No Three-Factor Interaction Model in Three-Way Contingency TablesKouji Yamamoto, Kyoji Hori, Sadao TomizawaProblem statement: For 2×2×K contingency tables, the measure is considered to represent the degree of departure from a log-linear model of No Three-Factor Interaction (NOTFI). We are interested in considering a similar measure for general I×J×K contingency tables. Approach: The present study proposed a measure to represent the degree of departure from the NOTFI model for I×J×K contingency tables. Also … …Current Research in Biostatistics, Vol. 1, Issue 1 · 30 Jun 2010 · 7,783 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Dynamics Studies of Human β-GlucuronidaseIbrahim Ali Noorbatcha, Ayesha Masrur Khan, Hamzah Mohd SallehProblem statement: The enzyme β-glucuronidase is being used as a reporter molecule in the area of genetic engineering, as a component of prodrug therapy in cancer treatment and in the scouring process of cotton fabrics. However, a detailed understanding of the factors responsible for the stability and the activity of this enzyme is still not available. Molecular Dynamics (MD) simulations … …American Journal of Applied Sciences, Vol. 7, Issue 6 · 30 Jun 2010 · 7,613 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin, Quercetrin Except Rutin Potentially Increased Pirarubicin Cytotoxicity by Non-Competitively Inhibiting the P-Glycoprotein-and MRP1 Function in Living K562/adr and GLC4/adr CellsWinit Choiprasert, Nathupakorn Dechsupa, Suchart Kothan et al.Problem statement: Quercetin and its glycoside derivatives are increasingly receiving interests as new generation of anticancer molecules and were recognized by multidrug resistant transporters such as P-glycoprotein and MRP1 protein. Of relevance to their use as anticancer agents alone or in combination with other agents, this study aims to analyze the interaction of the compounds with the MDR transporters including … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 9,670 accessesView PDFCite
Research ArticleOpen accessIn the abstractHypoglycaemic Effects of Dietary Intake of Ripe and Unripe Lycopersicon esculentum (Tomatoes) on Streptozotocin-Induced Diabetes Mellitus in RatsA. M. Akinnuga, O. Bamidele, O. A. Ebunlomo et al.Ripe and unripe tomatoes have been implicated in prevention of chronic diseases such as cancer probably due to their antioxidant, antibiotic, antifungal and anti-inflammatory properties. Problem statement: This study was designed to investigate whether ripe and unripe tomatoes will have hypoglycaemic effect in a chronic disease such as diabetes mellitus that has been characterized with hyperglycaemia. Approach: Twenty albino Wistar … …OnLine Journal of Biological Sciences, Vol. 10, Issue 2 · 24 Mar 2010 · 8,764 accessesView PDFCite
Research ArticleOpen accessIn the abstractScreening of Breast Mass in Iraqi Females: Al-Kindy Hospital Breast ClinicWijdan AkramProblem statement: The aim of this study is to present the findings of a retrospective analysis in females with breast mass, the character of the women and the risk factors of breast cancer at Al-Kindy Breast Clinic Center. Approach: Data were collected during 2 months period using special form of questioner. The total number of studied sample was 60, which … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 6,803 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Health and Toxic Adverse Effects of Fusarium Fungal Mycotoxin, Fumonisins, on Human PopulationW. M. Wan Norhasima, A. S. Abdulamir, F. Abu Bakar et al.Problem statements: Fumonisin was a mycotoxin produced mainly by fungi belonging to the genus Fusarium in various foods and feeds. They occurred worldwide and were found predominantly in corn and in corn-based animal feeds and also can be found in other crops. Contamination of food and feed with fumonisins has been implicated in and associated with a number of diseases … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 9,030 accessesView PDFCite
Research ArticleOpen accessIn the abstractHelicobacter pylori Colonization in Biopsies of the Adenotonsillectomy SpecimensM. J. Zahedi, S. Darvish Moghadam, M. Ahmadi Mosavi et al.Problem statement: Helicobacter pylori (H. pylori) is a microaerophilic, gram negative bacillus, which can cause peptic ulcer and gastric cancer. Recurrent infection with this agent is considered as one of the reasons for failure of peptic ulcer treatment. Some studies have reported colonization of H. pylori in dental plaques, tonsils and adenoid tissues. Therefore oral cavity could be the source … …American Journal of Applied Sciences, Vol. 6, Issue 12 · 31 Dec 2009 · 6,929 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Widely Used Diagnostics "DNA Microarray"-A ReviewR. Manoj KumarProblem statement: DNA microarray technique is one of the latest advances in the field of molecular biology and medicine. It is a multiplex technique used in combination of bioinformatics and statistical data analysis. Since, 1995, the technique offers the possibility of conducting tens or hundreds of thousands of simultaneous hybridizations. Approach: This increased experimental efficiency permits high throughput and whole … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 7,787 accessesView PDFCite
Research ArticleOpen accessIn the abstractP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,504 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Air Pollution on Ozone Layer Thickness in Troposphere over the State of KuwaitH. O. Al Jeran, A. R. KhanTroposphere ozone layer acts as a shield against all ultraviolet radiation approaching the planet Earth through absorption. It was noticed in mid 80s that ozone layer has thinned on the poles of the planet due to release of man-made substances commonly known as Ozone Depleting Substances, (ODS) into its atmosphere. The consequences of this change are adverse as the harmful … …American Journal of Environmental Sciences, Vol. 5, Issue 3 · 30 Jun 2009 · 19,488 accessesView PDFCite