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336 articles for “In Vitro”
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Research ArticleOpen accessIn the abstractUterus-Relaxing Study of a Sudanese Herb (El-Hazha)Aimun Abdelgaffar Elhassan Ahmed, Robert Gaspar, Arpad Marki et al.Problem statement: The aim of this study is to investigate the pharmacological effects of the Methanolic-extract (AH2) of El-Hazha and its sub-fractions. Approach: These investigations were carried out on in vitro isolated uterus preparations from Non-Pregnant (NP) and Late-Pregnant rats (LP). In parallel displacement radio-ligand binding assay was performed for β-Adrenergic Receptors (β-ADR). Results: Showed that the herb and its … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,509 accessesView PDFCite
Research ArticleOpen accessIn the abstractNasal Administration of Quercetin Liposomes Improves Memory Impairment and Neurodegeneration in Animal Model of Alzheimer's DiseaseTerdthai Tong-un, Supaporn Muchimapura, Jintanaporn Wattanathorn, Wathita PhachonpaiProblem statement: At present, the development of protective strategy against Alzheimer’s Disease (AD) is increasing its importance due to the high prevalence of AD, a limitation of therapeutic efficacy and its high impacts on economic and social aspects. The development of the preventive and therapeutic strategy to protect against the path physiology induced by free radicals in AD from antioxidant … …American Journal of Agricultural and Biological Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 7,743 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin Liposomes via Nasal Administration Reduce Anxiety and Depression-Like Behaviors and Enhance Cognitive Performances in RatsTerdthai Tong-Un, Panakaporn Wannanon, Jintanaporn Wattanathorn, Wathita PhachonpaiProblem statement: At present, the prevalence of neuropsychological disorders particularly anxiety, depression and dementia are increase. Many strategies have been developed in order to increase the efficiency of treatment and decrease side effects. Oxidative stress has been reported to play an important role on various path physiological states. Quercetin is a flavonoid commonly found in fruits and vegetables. It has … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 9,034 accessesView PDFCite
Research ArticleOpen accessIn the abstractNasal Administration of Quercetin Liposomes Modulate Cognitive Impairment and Inhibit Acetylcholinesterase Activity in HippocampusTerdthai Tong-Un, Supaporn Muchimapura, Wathita Phachonpai, Jintanaporn WattanathornProblem statement: Oxidative stress is a major factor implicated in the degeneration of cholinergic neurons in Alzheimer’s Disease (AD). Several reports have indicated that antioxidant intake is beneficial to delay or inhibit the progression of this disease. Presently, Acetylcholinesterase (AChE) inhibitors are the mainstay of therapy for AD. Quercetin, one of the flavonoids in fruits and vegetables, has a powerful … …Neuroscience International, Vol. 1, Issue 1 · 30 Jun 2010 · 7,170 accessesView PDFCite
Research ArticleOpen accessIn the abstractExogenous Pyocyanin Alters Pseudomonas aeruginosa Susceptibility to CiprofloxacinGary D. Grant, Tian Tian Zhang, Lee S. Gloyne et al.This in vitro cell-based study identified the contributing role of pyocyanin in the resistance of Pseudomonas aeruginosa to ciprofloxacin. Problem statement: P. aeruginosa is the major pathogen in the Cystic Fibrosis (CF) lung with pyocyanin being a critical component of its virulence. Prevalence is high and, once acquired, chronic infection is difficult to eliminate. Ciprofloxacin remains a crucial oral agent … …Current Research in Microbiology, Vol. 1, Issue 1 · 30 Jun 2010 · 8,792 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Volatile Metabolites from Fungal Endophytes with Biocontrol Potential towards Fusarium oxysporum F. sp. cubense Race 4A.S.Y. Ting, S.W. Mah, C.S. TeeProblem statement: Fungal endophytes are widely studied for their potential as biocontrol agents towards fungal pathogens. In vitro assessments usually reveal their antibiosis and mycoparasitism nature, but little is understood regarding their production of volatile metabolites as mechanisms of antagonism. Approach: This study explored the potential of fungal endophytes in controlling the pathogen responsible for Fusarium wilt disease. Nine fungal … …American Journal of Agricultural and Biological Sciences, Vol. 5, Issue 2 · 30 Jun 2010 · 11,872 accessesView PDFCite
Research ArticleOpen accessIn the abstractScalp Induction Rate Responses to Cytokinins on Proliferating Shoot-Tips of Banana Cultivars (Musa spp.)Siamak Shirani, Meon Sariah, Wahab Zakaria, Mahmood MaziahProblem statement: The effect of cytokinins on scalp induction from in vitro propagating shoot tips of different banana (Musa spp. AAA and AAB) cultivars was studied. Approach: Proliferation rate increased with an increasing concentration of Benzyl Amino Purine (BAP) up to 22.2 µM while, lower level of BAP (11.1 µM) increased scalp induction. Results: Kinetin induced a lower number of … …American Journal of Agricultural and Biological Sciences, Vol. 5, Issue 2 · 30 Jun 2010 · 9,443 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntitumor and Quantitative Structure Activity Relationship Study for Dihydropyridones Derived from CurcuminBahjat A. Saeed, Kawkab Y. Saour, Rita S. Elias et al.Problem statement: Pyridones are known to have variety of biological activities like antitumor, antibacterial, antiinflamatory and antimalarial activities. This study presented antitumor evaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison. Approach: The compounds evaluated for a preliminary estimation of the in vitro tumor inhibiting activity against 11 of tumor cell lines by using Microculture Tetrazolium assay … …American Journal of Immunology, Vol. 6, Issue 1 · 31 Mar 2010 · 8,262 accessesView PDFCite
Research ArticleOpen accessIn the abstractProduction and Nutritional Quality of low elevation zone Grasslands and Kermes Oak Shrublands (Quercus coccifera L.) in the South-East Mediterranean BasinC. Roukos, K. Papanikolaou, S. Kandrelis et al.Problem statement: The objective of this study was to evaluate the production and nutrition quality of grasslands and kermes oak shrublands in Preveza Prefecture, northwest Greece. Approach: The study involved the collection of herbage and browse samples along a grazing period, from March to October for two consecutive years. In consequence, browse samples were manually separated to leaves and twigs. … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 1 · 31 Mar 2010 · 7,425 accessesView PDFCite
Research ArticleOpen accessIn the abstractFoxp3-Mediated Immunity of Human Pancreatic Cancer Cell Line PANC-1Renxi Wang, Gencheng Han, Jianan Wang et al.Problem statement: More and more evidences have shown that human cancer cells can express Foxp3, the regulatory T cell-associated transcription factor. The role of Foxp3 in human cancer cells is still unclear. We detected Foxp3 expression in human pancreatic cancer cell line PANC-1. SiRNA assays showed that Foxp3 expression suppressed the expression of TGF-β and IL-10 which could induce immune … …American Journal of Immunology, Vol. 5, Issue 4 · 11 Jan 2010 · 7,363 accessesView PDFCite