27 results for “surface protein”

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Research ArticleOpen accessIn the abstractInternalizing Versus Non-internalizing Receptors for Targeting L-Methioninase to Cancer CellsXiao-Ping Zang, Naveen R. Palwai, J. T. Pento, Roger G. HarrisonWe reported previously that L-methioninase targeted to the urokinase receptor of MCF-7 breast cancer cells is significantly more effective in inhibiting cell proliferation and migration than free L-methioninase both in vitro and in vivo. L-methioninase was targeted by linking at its amino terminus to an amino-terminal fragment (ATF) of urokinase. The ATF was selected for targeting because is has previously … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,818 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIntroduction of Three Complementary Technologies into Clinical Medicine: Development of New Diagnostic and Prognostic ParametersGernot P. Tilz, Marco Wiltgen, Ulrike Demel et al.Molecular medicine leads us to understand some diseases at the molecular level. Examples are the analysis of immune complexes and receptor - anti receptor compounds used in clinical medicine. Structural changes of some serum proteins occur in inflammation, neoplasie and autoimmunity. The detection and analysis of such structural modifications may offer a new field for the diagnosis, prognosis and therapy … …American Journal of Immunology, Vol. 2, Issue 1 · 31 Mar 2006 · 6,961 accessesView PDF Cite

Literature ReviewOpen accessIn the abstractFundamental Questions about γδT CellsMoulay Yassine Belghali, Saadia Ba-M’hamed, Mouna Khouchani, Brahim AdmouγδT cells is a minor subgroup of T lymphocytes expressing γδ-T Cell Receptor (TCR), with many subsets, dominated by Vδ2 and Vδ1. γδT cells recognize antigens independently of the context of MHC class I, MHC class II, or CD1 presenting molecules. However, this recognition requires the expression of the transmembrane Butyrophilin proteins by the presenting cells. Their activation is controlled … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 15 Dec 2020 · 6,384 accessesView PDF Cite

Research ArticleOpen accessIn the abstractProbing the Substrate Specificity and Intersubunit Interactions of Brevundimonas Diminuta Glutaryl Acylase with Site-Directed MutagenesisMichael Eldarov, Anna Lyashenko, Tatyana Sherbakova et al.Glutaryl-7-ACA acylases (GLA) are industrial enzymes widely used for the production of 7-aminocepahlosporanic acid (7-ACA)-the starting compound for manufacturing of semisynthetic cephalosporin antibiotics. Generation of mutant GLA's with increased activity and stability, capability for single-step conversion of cephalosporin C (CPC) directly to 7-ACA is a promising route to improve the current biocatalytic technologies. In this study GLA from Brevundimonas diminuta … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 12 Nov 2014 · 8,164 accessesView PDF Cite

Research ArticleOpen accessIn the abstractStudy of the Mandibular Glands of Ant Workers Atta sexdens rubropilosa (Forel, 1908) (Hymenoptera: Formicidae) Focusing the Ultrastructural CytochemistryLorena Favaro Pavon, Maria Izabel Camargo MathiasThe mandibular glands of hymenopterans in general are paired structures located on each side of the head. These glands possess an excretory duct located at the internal surface of the mandible articulation, through which these glands release the secretion they produce. The mandibular glands of the minima, media and soldier worker of the ant Atta sexdens rubropilosa were analyzed by … …American Journal of Agricultural and Biological Sciences, Vol. 1, Issue 2 · 30 Jun 2006 · 7,648 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordThe Use of Artificial Neural Networks in Analysis Cationic Trypsinogen Gene and Hepatitis B Surface AntigenLiu Qicai, Zeng Kai, Zhuang Zehao et al.Problem statement: More and more severe hepatitis cases reported in China are infected with HBV and the immune response of HBV will be reduced if mutations occur in the TCR, therefore it is very important to investigate the relation of T-cellular function and clinical effect by studying the function of T-cell receptor. Approach: Artificial Neural Networks (ANN) was applied to … …American Journal of Immunology, Vol. 5, Issue 2 · 30 Apr 2009 · 7,566 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordDownstream Ecocide from Upstream Water PiracyMiah Muhammad AdelUpstream India and downstream Bangladesh share more than 50 international rivers. India has set up water diversion constructions in more than 50% of these rivers, the largest one being on the Bangladesh’s northwest upon the Ganges River, puts Bangladesh’s Gangetic ecosystem at stake. In some border rivers, India has set up groins on her side of river banks. Also, Indian … …American Journal of Environmental Sciences, Vol. 8, Issue 5 · 4 Sep 2012 · 9,077 accessesView PDF Cite