25 results for “support structures”

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Research ArticleOpen accessIn the abstractHandling the Dependence of Claim Severities with Copula ModelsYulia Resti, Noriszura Ismail, Saiful Hafizah JaamanProblem statement: Several studies have been carried out on the modeling of claim severity data in actuarial literature as well as in insurance practice. Since it is well established that the claim cost distributions generally have positive support and are positively skewed, the regression models of Gamma and Lognormal have been used by practitioners for modeling claim severities. However, the … …Journal of Mathematics and Statistics, Vol. 6, Issue 2 · 30 Jun 2010 · 7,528 accessesView PDF Cite

Research ArticleOpen accessIn the abstractUnbalance Quantitative Structure Activity Relationship Problem Reduction in Drug DesignD. Pugazhenthi, S. P. RajagopalanProblem statement: Activities of drug molecules can be predicted by Quantitative Structure Activity Relationship (QSAR) models, which overcome the disadvantage of high cost and long cycle by employing traditional experimental methods. With the fact that number of drug molecules with positive activity is rather fewer than that with negatives, it is important to predict molecular activities considering such an unbalanced … …Journal of Computer Science, Vol. 5, Issue 10 · 31 Oct 2009 · 6,704 accessesView PDF Cite

Research ArticleOpen accessIn the abstractUltrastructural and Immunological Characterization of Hepatitis C Core Protein-DNA Plasmid ComplexesNelson Acosta-Rivero, Yaraima Aguilera, Viviana Falcon et al.Recently, it has been shown that a truncated HCV core (HCcAg) variant, covering the first 120 aa (HCcAg.120), interacts with plasmid DNA vaccine (pIDKE2), encoding the HCV structural proteins (HCcAg, E1 and E2). In the present work, HCcAg.120-pIDKE2 complexes, forming heterogeneous packaged structures, were visualized using a negative stain/rotary shadow technique. Interestingly, 72 hours after intramuscular injection of HCcAg.120-pIDKE2 complexes … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,743 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordONCODIAG Select and Test (ST) Algorithm: An Approximate Clinical Reasoning Model for Diagnosing and Monitoring Breast CancerO.N. Oyelade, A.A. Obiniyi, S.B. JunaiduClinical reasoning involves coordinated thinking strategies targeted at gathering and analyzing relevant information to arrive at a high-quality clinical solution to patients' medical problems. The correctness and proper choice of clinical reasoning approach chosen by a clinician or machine affect the accuracy and acceptability of the diagnosis; moreover, another challenge that usually surfaces during clinical reasoning is the burden of … …Current Research in Bioinformatics, Vol. 9, Issue 1 · 22 Feb 2020 · 8,936 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordTolemerase Reverse Transcriptase Gene Expression as a Tumor Marker for Hepatocellular CarcinomaM. Magdi Atta, Naglaa Al-Toukhy, Omnia Al-Said et al.Problem statement: Hepatocellular carcinoma will emerge as a major form of malignancy in the coming decades. The continuing high incidence of hepatocellular carcinoma, suggests that this disease will continue to represent a global health problem far into the future. Different genes encode for the various components of the human telomerase complex. These components include the human Telomerase RNA Component (hTERC) … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 3 Aug 2011 · 7,905 accessesView PDF Cite