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137 articles for “response function”
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EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite
EditorialOpen accessIn the abstractRe-Paving the Road Built by Chemistry: A Challenge to Biochemistry and BiotechnologyAlberto A. IglesiasBiochemistry’s birth can be placed at the end of the nineteenth century, when Eduard Buchner made a clever interpretation of experimental observations on the generation of gas bubbles after addition (the original purpose was preservation) of sucrose to a yeast crude extract (Lagerkvist, 2005). Intelligently, Buchner concluded that the disaccharide had been fermented by broken cells’ suspension to produce CO2, … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 1 · 26 Jan 2015 · 7,461 accessesView PDFCite
Research ArticleOpen accessIn the abstractDEVELOPMENT OF THE INNATE IMMUNE RESPONSE AND INFLUENCE OF COLOSTRUM SUCKLING IN CALVESViviani Gomes, Camila Costa Baccili, Vinicius Alvim Passos Baldacim et al.Bovine colostrum contains immune factors, like leukocytes and cytokines that are absorbed by the intestinal mucosa of the neonate, however, not much is known about the function of some of these components in the active immune response of calves. The aim of this study was to determine the influence of colostrum intake and development of the innate immune response of … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 2 · 14 Apr 2014 · 7,475 accessesView PDFCite
Research ArticleOpen accessIn the abstractTHE NAME PATHWAY, AN ELEMENTARY COGNITIVE MODEL OF NAMES AS SENSORY REPRESENTATIONSS. Balachandra DassNames function as sensory representations, but the relationship between names and sensory stimuli/responses remains unclear. This study proposes the existence of a class of stimulus-response pathways, the name pathway, where a name is a reproducible and communicable symbol and the name pathway is one where the same name is both the stimulus and the response. Once a stimulus-response &#34name&#34 pathway … …Neuroscience International, Vol. 5, Issue 1 · 3 Apr 2014 · 7,250 accessesView PDFCite
Research ArticleOpen accessIn the abstractEfficacy Assessment of Kaempferia parviflora for the Management of Erectile DysfunctionPanakaporn Wannanon, Jintanaporn Wattanathorn, Terdthai Tong-Un et al.Age-related decline in erectile function is a noted phenomenon worldwide. A variety of medicinal plants have been identified as having strong aphrodisiac properties along with the ability to improve erectile functioning. Kaempferia Parviflora (KP) has famous as a Thai Viagra and use it to increase male impotency. However, there is limited scientific evidence regarding the efficacy of this herb on … …OnLine Journal of Biological Sciences, Vol. 12, Issue 4 · 4 Feb 2013 · 19,852 accessesView PDFCite
Research ArticleOpen accessIn the abstractModeling Tourist Arrivals Using Time Series Analysis: Evidence From AustraliaGurudeo AnandTularam, Victor Siew Howe Wong, Seyed AbdelhamidShobeiriNejadAustralian tourism has a logistic trend as Butler’s model shows. The stagnation has not been reached so opportunities exist to increase tourism. The logistic model predicts 7.2 million tourists in 2015 but time series models of ARIMA and VAR improve the prediction and explain the data. The ARIMA (2, 2, 2) fits well while the VAR lead to Granger causalities … …Journal of Mathematics and Statistics, Vol. 8, Issue 3 · 10 Sep 2012 · 7,857 accessesView PDFCite
Research ArticleOpen accessIn the abstractCell-Based Therapies in the Prevention of Solid Organ Transplant RejectionAdrian E. Morelli, Sherrie J. DivitoProblem statement: Organ transplantation is a life-saving and increasingly common procedure, as it often serves as the only treatment available for end-stage organ disease. Although the constant development of new and more effective immunosuppressive drugs has revolutionized the prevention and treatment of acute graft rejection, these drugs have significant toxicity, greatly increase patient susceptibility to neoplasms and infection and exert … …American Journal of Immunology, Vol. 8, Issue 2 · 26 Jul 2012 · 7,416 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluating some Reliability Analysis Methodologies in Seismic DesignA. El Ghoulbzouri, A. Khamlichi, F. Lopez Almansa et al.Problem statement: Accounting for uncertainties that were present in geometric and material data of reinforced concrete buildings was performed in this study within the context of performance based seismic engineering design. Approach: Reliability of the expected performance state is assessed by using various methodologies based on finite element nonlinear static pushover analysis and specialized reliability software package. Reliability approaches that … …American Journal of Engineering and Applied Sciences, Vol. 4, Issue 3 · 18 Aug 2011 · 7,843 accessesView PDFCite
Research ArticleOpen accessIn the abstractSubway Train Braking System: A Fuzzy Based Hardware ApproachMamun Bin Ibne Reaz, Jubayer Jalil, Hafizah Husain, Badariah BaisProblem statement: Automated subway train-braking system require perfection, efficiency and fast response. In order to cope with this concerns, an appropriate algorithm need to be developed which need to be implemented in hardware for faster response. Approach: In this research, the FPGA realization of fuzzy based subway train braking system has been presented on an Alter FLEX10K device to provide … …American Journal of Applied Sciences, Vol. 8, Issue 7 · 24 Jun 2011 · 7,175 accessesView PDFCite