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Research ArticleOpen accessEvery word in the titleEffect of Short Time Morphine Addiction on the Kidney Tissue in RatReza Malekpourafshar, Hamid ZeinalinejadOpium is an important substance that abuses and has very pharmacological and pathological effects. Morphine is the main substance of opium. In the recent study, it has been tried to identify the short effects of morphine on the kidney pathology of Rats. The randomized double blind study was designed. Twenty rats were selected and divided in two groups and maintained … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 4 · 31 Dec 2005 · 6,397 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIncreased Production of Nitric Oxide Contributes to Renal Oxidative Stress in Endotoxemic RatBahar Tunçtan, Belma Korkmaz, Hatice Yıldırım et al.Overproduction of reactive oxygen and nitrogen species leads to oxidative stress and decreased total antioxidant capacity, which is responsible for high mortality from several diseases such as endotoxic shock. Nitric oxide (NO) produced by inducible NO synthase (iNOS) during endotoxemia is the major cause of vascular hyporeactivity, hypotension and multiple organ failure. In this study, we investigated whether increased production … …American Journal of Infectious Diseases, Vol. 1, Issue 2 · 30 Jun 2005 · 8,638 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTumor Suppressor P53 Gene Mutations Pattern Induced by Repeated Fried Palm Oil in RatsAbeer A.I. Hassanin, Abeer G.A. Hassan, Saadia A. Ali, Takao ItakuraThe present study aimed to examine the presence of p53 gene mutations in white albino rats fed on repeated fried palm oil. Eighteen sexually mature male Albino rats were used throughout the experiment. Rats were divided randomly into three groups, 6 animals each, namely; control group (CO) which orally administered by distilled water (NO) group which fed on basal diet … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 19 Dec 2014 · 7,696 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEFFECT OF DIMETHOATE (AN ORGANOPHOSPHATE INSECTICIDE) ON THE REPRODUCTIVE SYSTEM AND FERTILITY OF ADULT MALE RATFerdinand Ngoula, Pierre Watcho, Augustave Kenfack et al.The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dimethoate is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. In the present study, we investigated the effect of dimethoate (an organophosphate insecticide) on the reproductive system and fertility of male … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 13 Feb 2014 · 8,595 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHepatoprotective Effect of Taurine Against Oxidative Stress Due to Methotrexate in RatE. Issabeagloo, M. Taghizadiyeh, P. KermanizadehProblem statement: Taurine, 2-aminoethanesulphonic acid is an essential amino acid. It is present at high concentrations in many tissues. It plays important roles in numerous physiological functions including conjugation with bile acids, modulation of calcium levels and maintenance of osmolarity, antioxidation and stabilization of membranes. Methotrexate (MTX), as the most disease modifying anti-rheumatic drug used for Rheumatoid Arthritis (RA), has … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 16 Jan 2012 · 8,495 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDihydroartemisinin-Stimulated Hyperplasia of Rat Lung Smooth MusclesUtoh-Nedosa Uchechukwu AnastasiaProblem statement: Dihydroartemisinin was shown to produce two types of inhibitory effects on the cardiac muscles of rats. It was also shown to stimulate haemopoiesis in the lungs, liver, spleen, intestine and kidney of rats. This study attempted to find out the nature of the effect of oral dihydroartemisinin on the lungs of Wistar albino rats. Approach: The effects of … …American Journal of Applied Sciences, Vol. 9, Issue 2 · 8 Dec 2011 · 7,024 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAnti-Arthritic Activity of the Methanolic Leaf Extract of Urtica pilulifera L. on Albino RatsSuha Abudoleh, Ahmad Disi, Eyad Qunaibi, Talal AburjaiProblem statement: Urtica pilulifera (Urticeacae) has been used in folk medicine to alleviate inflammation and arthritis. In this study the anti-arthritic effect of methanolic leaf extract of the plant was evaluated and compared to untreated control as well as ibuprofen-treated groups in a rat model of Complete Freund's Adjuvant (CFA)-induced arthritis. Approach: Arthritis was induced by injecting CFA subcutaneously into … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 1 · 14 Jun 2011 · 10,431 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Sodium Fluoride on Cancellous Bone Defect Healing in RatsGhafour Mousavi, Daryoush Mohajeri, Mostafa Rezaei et al.Problem statement: The purpose of this study was to histopathology and biomechanics evaluate the effect of sodium fluoride on cancellous bone defect healing in rat model. Approach: The experiment was conducted on 40 male adult SD rats which were divided into four groups of control and experiments. After induction of general anesthesia, a hole in size of 2×3 mm in … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 7,092 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleModulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon ExtractMohamed H. Mahfouz, Hala M. Ghanem, Mona A. MohamedCinnamon Extract (CE) has shown to be generally safe when ingested and to have many pharmacological properties. Problem statement: Study the effects of daily intake of CE on the modulation of hepatic, cardiac Insulin Receptor Substrate-1 (IRS-1) and their relations to some inflammatory variables in hyperinsulinemic rats. Approach: The influence of CE administered orally was studied in hyperinsulinemic rats. Eighteen … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 7,810 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCamel's Milk Protects Against Cadmium Chloride-Induced Hypocromic Microcytic Anemia and Oxidative Stress in Red Blood Cells of White Albino RatsMohammad DallakProblem statement: Cadmium is a heavy metal of wide occupational and environmental contamination. In recent years, however, Cadmium has been implicated in the pathogenesis of several clinical disorders. One of the most frequently described problems in aluminum toxicity is anemia. Therefore, the present study was carried out to determine the effectiveness of Camel's milk in alleviating the toxicity of Aluminum … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 8,683 accessesView PDFCite