Sign inSubmit
Tips: “quotes” for a phrase · author:Lee · a DOI goes straight to its article

33 articles for “pivotal role”
Set a search alert
Also matching:1 special issue
EditorialOpen accessIn the abstractUse of Design of Experiments and Manuscripts Rejection RateAydin Berenjian, Jason RyanTraditional one-variable-at-a-time method was and still is for some researchers, the general procedure to determine the optimal conditions for a chemical, biochemical or biological mechanism. According to this technique, a large number of experiments should be performed to obtain a high precision in effect assessment and also the interaction among the variables cannot be defined. To overcome the limitations of … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 2 · 8 Jun 2015 · 7,174 accessesView PDFCite
EditorialOpen accessIn the abstractGLUTATHIONE: A POSSIBLE LINK TO AUTOPHAGY IN SYSTEMIC LUPUS ERYTHEMATOSUSDilip Shah, Swapan K. NathIncreased free radical formation and altered redox state are of fundamental importance in the pathogenesis of autoimmune diseases including Systemic Lupus Erythematos (SLE). Free radicals are mainly derived from oxygen (Reactive Oxygen Species/ROS) and nitrogen (Reactive Nitrogen Species/RNS) at mitochondria, cellular membranes and the endoplasmic reticulum membrane as physiological responses to a variety of internal and external stress (Shah et … …American Journal of Immunology, Vol. 10, Issue 3 · 3 Sep 2014 · 12,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractCASE STUDY OF THE OPTIMIZING THE AUTOMOTIVE MANUFACTURING SYSTEMS EFFICIENCY VIA APPLYING NEW METHOD OF SCHEDULINGSeyedehfarzaneh Nojabaei, Matthew FranchettiEfficiency is becoming a pivotal aspect in each manufacturing system and scheduling plays a crucial role in sustaining it. The applicability of distributed computing to coordinate and execute jobs has been investigated in the past literature. Moreover, it is significant that even for sensitive industrial systems the only criterion of allocating jobs to appropriate machines is the FIFO policy. On … …American Journal of Engineering and Applied Sciences, Vol. 7, Issue 2 · 8 Jul 2014 · 7,426 accessesView PDFCite
Research ArticleOpen accessIn the abstractLOW FOOTPRINT HIGH INTELLIGIBILITY MALAY SPEECH SYNTHESIZER BASED ON STATISTICAL DATALau Chee Yong, Tan Tian SweeSpeech synthesis plays a pivotal role nowadays. It can be found in various daily applications such as in mobile phones, navigation systems, languages learning software and so on. In this study, a Malay language speech synthesizer was designed using hidden Markov model to improve the performance of current Malay speech synthesizer and also extend Malay speech technology. Statistical parametric method … …Journal of Computer Science, Vol. 10, Issue 2 · 19 Nov 2013 · 6,725 accessesView PDFCite
Research ArticleOpen accessIn the abstractE-Learning Initiative Capacity Building for Healthcare Workforce of Developing CountriesNurhizam Safie, Syed AljunidThis study aims to explicate the strategic utilisation of e-learning is of upmost significance as e-learning plays a pivotal role in the improvement of healthcare learning and knowledge transfer, especially in developing countries and in pursuing of Millennium Development Goals (MDGs). Rapid technology changes in the learning and knowledge transfer landscape markedly, the swift pace of e-learning leaving healthcare providers … …Journal of Computer Science, Vol. 9, Issue 5 · 23 May 2013 · 7,765 accessesView PDFCite
Research ArticleOpen accessIn the abstractCardiotrophin-1 in Patients with Acute Myocardial InfarctionAbdolreza Sotoodeh Jahromi, Mohammad Shojaie, Abdoulhossain MadaniProblem statement: Myocardial infarction is the combined result of environmental and personal factors. Prothrombotic factors might play an important role in this phenomenon. Inflammation plays a pivotal role in atherosclerosis and coronary heart disease. Cardiotrophin-1 (CT-1), a member of the IL-6 family of cytokines, was identified as a growth factor for cardiac myocytes that induces cardiomyocyte hypertrophy and stimulates cardiac … …American Journal of Applied Sciences, Vol. 7, Issue 9 · 30 Sep 2010 · 7,243 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Exercise Training on Adiponectin Receptor Expression and Insulin Resistance in Mice Fed a High Fat DietNaglaa Fathy Alhusseini, Nasr Arafat Belacy, Enas Mohammed Kasem, Mona Maher AllamProblem statement: Adiponectin is an adipocyte secreted hormones, exerts its effects via the specific receptors. AdipoR1 and adipoR2 and plays a pivotal role in lipid and glucose metabolism. Approach: We investigated the effect of increased physical activities on insulin resistance and if this effect is modulated through adiponectin receptor expression. Results: We also assessed the effect of High Fat Diet … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 9,956 accessesView PDFCite
Research ArticleOpen accessIn the abstractGenomic Distance between Thymidylate Synthase and Dihydrofolate Reductase Genes Does Not Correlate With Phylogenetic Evolution in BacteriaVitor Hugo MoreauProblem statement: Dihydrofolate Reductase (DHFR) and Thymidylate Synthase (TS) exist as bifunctional enzymes coded into unique polypeptide chain in protozoans. Bifunctional DHFR-TS is associated with an increase in the enzymatic activity by channeling the substrate between the active sites. In some bacteria, DHFR and TS genes are neighbors in the genome, whereas in others, they are located millions of base … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 8,196 accessesView PDFCite
Research ArticleOpen accessIn the abstractFarmers' Perception about the Extension Services and Extension Workers: The Case of Organic Agriculture Extension Program by PROSHIKAMd. Asaduzzaman Sarker, Yoshihito ItoharaProblem statement: Need of agricultural information is the basic necessity for the farmers as it plays a pivotal role in enlightening them, raising their level of knowledge and eventually help in their decision making process regarding farming activities. Extension workers with their extension services are doing this noble work. PROSHIKA a renowned NGO in Bangladesh is promoting organic agriculture among … …American Journal of Agricultural and Biological Sciences, Vol. 4, Issue 4 · 31 Dec 2009 · 8,279 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Treg Cells in the Cancer Immunological ResponseZhi-Zhang Yang, Stephen M. AnsellProblem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 8,524 accessesView PDFCite