Research ArticleOpen accessIn the abstractHormetic Triggers for Intervention in Aging, Disease and TraumaJoan Smith SonnebornHormesis refers to the ability of a chemical or physical agent to condition the physiological state of an organism to tolerate stress with low doses of otherwise harmful agents. Evolutionary evidence shows that the survival and longevity of species hinge on their optimal ability to resist stress challenge. Hormesis is a potent strategy to stimulate latent repair processes to tolerate … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,895 accessesView PDFCite
Research ArticleOpen accessIn the abstractPharmacophore Pattern Identification of Tachykinin Receptor Selective Peptide Agonists: Implications in Receptor SelectivityAnjali Dike, Indu R. Chandrashekaran, Anil K. Mantha et al.The mammalian tachykinin (TK) peptides and their three Neurokinin (NK1, NK2 and NK3) receptors represent an effector system with wide-ranging actions on neuronal, airway smooth muscle, mucosal, endothelial, immune, inflammatory and remodeling cell function. Recent clinical and preclinical data suggests the pathophysiological role of TKs in various diseases including asthma, emesis and depression. The TK-NK receptor interactions and overlapping functions … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,691 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of HIV-1 Infection in Addictive Behavior: A Study of a HIV-1 Transgenic Rat ModelSulie L. Chang, Michael VigoritoEpidemiological research indicates that drug abuse is prevalent among individuals infected with HIV-1. Evidence from preclinical research also suggests that drugs of abuse exacerbate the progression of neuropathological changes in the HIV-1 infected brain probably through common mechanisms of neuronal injury. The effects of HIV-1 on the efficacy and abuse potential of controlled drugs such as morphine, however, has not … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 7,630 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordThe Glia Connection of the Glutamate/Glutamine ShuttleAngelina Rodriguez, Arturo OrtegaProblem statement: Glia cells outnumber neurons but their role in synaptic transmission is still matter of debate. The recycling of Glutamate, the main excitatory neurotransmitter, carried out by the glutamate/glutamine shuttle, requires the involvement of glia, suggesting their involvement in neurotransmission. Approach: This review focuses on novel functions of glia proteins involved in this cycle. Results: An activity-dependent interaction of … …Neuroscience International, Vol. 3, Issue 1 · 3 Sep 2012 · 7,770 accessesView PDFCite