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Research ArticleOpen accessIn the abstractRole of the Wnt/β-Catenin Signaling Pathway in Reducing Lipogenesis of Obese Rats Under Hypoxic ExercisePeiming Xu, Zhiyuan Sun, Xiaoyi Tian et al.Hypoxic exercise exerts a significant effect on body weight loss and body fat reduction. Methods: In the present study, we constructed an obese rat model and divided rats into the following groups: Normoxic quiet (C), Hypoxic quiet (H), Normoxic Exercise (CE), and Hypoxic Exercise (HE). We employed isobaric tags for relative and absolute quantification (iTRAQ) using proteomic technology to screen … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 2 · 3 Jun 2022 · 5,744 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Cinnamomum cassia Stem-Bark Extracts on the Synthesis and Secretion of Insulin in RIN-m5F CellsAnanias Hodi Kgopa, Sebolaishi Doris Makhubela, Motetelo Alfred Mogale, Leshweni Jerry ShaiCinnamomum cassia (C. cassia) crude stem-bark extracts possess some hypoglycemic properties through inhibiting the uptake of glucose by the intestines and/or enhancing insulin sensitivity. To further investigate the mechanism through which the hypoglycemic effect is exerted, this research explored the influence of the extracts of the crude stem-bark of C. cassia, with various polarities, on particular aspects of glucose consumption … …OnLine Journal of Biological Sciences, Vol. 22, Issue 2 · 5 Apr 2022 · 5,788 accessesView PDFCite
Research ArticleOpen accessIn the abstractPunicalagin Suppresses Mediators Involved in Labor Onset and Progression in vitroCaitlyn Nguyen-Ngo, Jane C Willcox, Martha LappasSpontaneous preterm birth is the leading cause of neonatal morbidity and mortality. Inflammation plays a central role in the activation of myometrial contractions and rupture of fetal membranes associated with spontaneous preterm birth. The pomegranate polyphenol punicalagin is known to possess anti-inflammatory properties. In this study, we aimed to determine the effect of punicalagin on pro-inflammatory and pro-labor mediators in … …American Journal of Immunology, Vol. 17, Issue 1 · 22 Dec 2021 · 7,613 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin Promotes the Expression of Genes Involved in Phagocytosis in Bovine NeutrophilsSuphakit Srikok, Sukij Nambut, Kanruethai Wongsawan, Phongsakorn ChuammitriThis study was conducted to explore the effect of Quercetin (QH) on phagocytosis of bovine neutrophils. Neutrophils were isolated from fifteen multiparous Holstein cows. We in vitro treated neutrophils with PBS or 50 µM of Quercetin (QH) or Cytochalasin B (CytB), as phagocytosis inhibitor, prior to monitoring phagocytosis of Escherichia coli by flow cytometry and microscopic examination. Additionally, the expressions … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 2 · 2 Aug 2017 · 8,124 accessesView PDFCite
Research ArticleOpen accessIn the abstractHumoral and Cellular Effects of Stress-An Extensive Model SystemMazal Shimon-Hophy, Ramy R. AvtalionThe influence of stress on the immune system of the common carp (Cyprinus carpio) was studied by measuring leukocytes levels using flow cytometry and mRNA immune components by real time qPCR. Acute and chronic oxidative stresses were generated by different regimes of exposure of carp to environmental air. In acute stress, induced by single air exposure, the pro-inflammatory cytokines (IL1β, … …American Journal of Immunology, Vol. 13, Issue 2 · 18 Apr 2017 · 6,728 accessesView PDFCite
Research ArticleOpen accessIn the abstractPotential of HMEC-1 Line and HUVEC Primary Culture Cells to Study the Neonatal IgG Fc Receptor in vitroLuz Belinda Ortiz-Alegría, Irma Cañedo-Solares, Felipe Vadillo-Ortega et al.The neonatal IgG Fc receptor (FcRn) plays an important role in IgG homeostasis and immunity passive transfer. Fine points regarding these mechanisms, however, are still emerging. In order to obtain information about these phenomena, it is essential to have in vitro models of endothelium that express this receptor. In this study we chose two widely used models of human endothelial … …American Journal of Immunology, Vol. 12, Issue 1 · 21 Mar 2016 · 9,455 accessesView PDFCite
Research ArticleOpen accessIn the abstractGene Expression Profiling of Toll-Like Receptor 4 and 5 in Peripheral Blood Mononuclear Cells of Patients with Systemic SclerosisSimin Almasi, Saeed Aslani, Hadi Poormoghim et al.The Toll-Like Receptor (TLR) family is appeared to be expressed in many cell types in the immune system and plays a role in the pathogenesis of various autoimmune diseases. The expression profile and role of TLRs in Systemic Sclerosis (SSc) have been partly explained. It is aimed through this investigation to evaluate the expression pattern of TLR 4 and 5 … …American Journal of Immunology, Vol. 12, Issue 1 · 17 Mar 2016 · 7,051 accessesView PDFCite
Review ArticleOpen accessIn the abstractRole of Cytokines and Transcription Factors in Periodontitis: A Review of Cellular and Molecular MechanismsAnne Carolina Eleutério Leite, Valéria Martins de Araújo Carneiro, Júlia Faria Nunes et al.Periodontal Diseases (PD) are characterized by pathological manifestation of host immune response to bacterial infection at the tooth/gingival interface. Evidences points periodontitis as a risk factor for pathological systemic conditions, such as, cardiovascular diseases and diabetes. The identification of host factors that determine their susceptibility to immune subversion can provide useful information in the pathogenesis of periodontitis. Protective acute inflammatory … …American Journal of Immunology, Vol. 11, Issue 4 · 9 Dec 2015 · 7,809 accessesView PDFCite
Research ArticleOpen accessIn the abstractGenomic Signature of Respiratory Microbes on Human Scalp EpitheliaBhola Nath Paul, Vani Mishra, Jasmeet Kaur Chhabra, Divyani PaulDespite overlap between habitats occupied by diverse Airborne Respiratory Microbes (ARM), the airway epithelium is known for respiratory microbe infections, human scalp epithelium is undocumented. Analogous to airways epithelium, the scalp epithelium is vulnerable to infection by dormant variants of sensitive microbes that underlie many chronic and relapsing diseases, difficult to eradicate by conventional antibiotics and challenged our ability to … …American Journal of Immunology, Vol. 11, Issue 3 · 11 Sep 2015 · 7,079 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of Interleukin-6 Expression by Curcumin in Rat Vascular Smooth Muscle Explants In VitroYanti, Stephanie, Yuliani et al.In atherosclerotic plaques, infectious agents from microbes may release Lipopolysaccharide (LPS) and heat shock proteins that can stimulate the production of mediators, i.e., pro-inflammatory cytokines, by vascular endothelial cells and Smooth Muscle Cells (SMCs). The elevated level of Interleukin-6 (IL-6) is strongly associated with the development of atherosclerosis. Here, we investigated whether curcumin isolated from the rhizome of Curcuma longa … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 15 Dec 2014 · 6,777 accessesView PDFCite