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212 results for “liver”
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Research ArticleOpen accessEvery word in the titleEffect of Heat Stress on the Expression of HSP70, UCP3 and CYP450 Genes in Liver; Longissimus Dorsi and Semitendinosus Muscle of Growing PigsV. Montesinos-Cruz, M. Cota, L. Buenabad et al.High Ambient Temperature (AT) provokes Heat Stress (HS) in animals, which is characterized by increased body temperature, Reactive Oxygen Species (ROS) production and cell damage. Uncoupling Proteins (UCP) may contribute to dissipate body heat, cytochrome P450 (CYP3A4) reduces ROS and Heat Shock Proteins (HSP) prevent protein denaturalization. This study analyzed the expression of HSP70, UCP3 and CYP3A in liver, Longissimus … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 4 · 24 Oct 2019 · 7,867 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSex Dimorphism in the Fgf21 Gene Expression in Liver and Adipose Tissues is Dependent on the Metabolic ConditionNadezhda Bazhan, Tatiana Jakovleva, Natalia Balyibina et al.Fibroblast growth factor-21 (FGF21) beneficially affects carbohydrate and lipid metabolism. Previously, a sex-specific activation of Fgf21 expression was observed in humans and animals with metabolic diseases. It is unknown whether the sex differences in the Fgf21 expression are manifested in response to the natural physiological situations of fasting and refeeding. The aim of this work was to determine liver, White … …OnLine Journal of Biological Sciences, Vol. 19, Issue 1 · 29 Jan 2019 · 8,153 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSerum Ornithine Carbamoyltransferase Activity and Correlation with Fatty Liver in Dairy Cows with Displaced AbomasumKen Onda, Reiichiro Sato, Yosuke Sasaki et al.Ornithine Carbamoyltransferase (OCT) is a hepatocyte-specific enzyme; elevated serum activity indicates liver damage. Displaced abomasum frequently occurs around the time of parturition in dairy cattle and is associated with fatty liver. We analyzed serum OCT activities to investigate the relationship between displaced abomasum and fatty liver. Lactating Holstein cows, 75 clinically healthy and 22 with displaced abomasum, were used. Serum … …American Journal of Animal and Veterinary Sciences, Vol. 11, Issue 3 · 13 Jul 2016 · 7,660 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleConstitutive Androstane Receptor Dependent and Independent Modulation of CYP3A2, CYP1A2 by Phenobarbital and Fibrate in Rats’ LiverMohamed Mohamed Ahmed, Mustafa Shukry, Zein Shaban Ibrahim et al.Cytochrome P450 enzymes, CYP3A and CYP1A are major drug metabolizing enzymes in the liver. CYP3A enzymes have a major role in the metabolism of 30-40% of all used drugs. CYP1A2 is a key enzyme having an important role in the metabolic clearance of 5% of currently marketed drugs. CYP1A2 participates in the metabolic activation of chemical mutagens in cooked food, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 7,381 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleContent Based Image Retrieval of Ultrasound Liver Diseases Based on Hybrid ApproachR. Suganya, S. RajaramProblem statement: In the past few years, immense improvement was obtained in the field of Content-Based Image Retrieval (CBIR). Nevertheless, existing systems still fail when applied to medical image databases. Simple feature-extraction algorithms that operate on the entire image for characterization of color, texture, or shape cannot be related to the descriptive semantics of medical knowledge that is extracted from … …American Journal of Applied Sciences, Vol. 9, Issue 6 · 24 Mar 2012 · 7,643 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEvaluation of in vivo Antioxidant and Hepatoprotective Activity of Portulaca oleracea L. against Paracetamol-Induced Liver Toxicity in Male RatsMohamed H. AhmidaProblem statement: Oxidative stress plays a major role in paracetamol induced hepatotoxicity. Portulaca oleracea (P.O.) has been shown to exhibit antioxidant properties. The present study aimed to investigate the effect of P.O. on the oxidative stress in Paracetamol-induced hepatic toxicity in male rats. Approach: Forty male rats were divided into four groups. Group I served as control; Group II Received … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 7,327 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMethamphetamine Regulation of Sulfotransferases in Rat Liver and BrainTianyan Zhou, Chaoqun Huang, Yue Chen et al.Problem statement: Sulfotransferases (SULTs) are important phase II drug metabolizing enzymes. They also regulate the biological activities of various hormones. To the best of our knowledge, psychostimulants regulation of SULTs is basically not studied except one article reported that Methamphetamine (METH) treatment induced rat amygdale rSULT1A1 mRNA 4.3 fold by using microarray method to identify a series of candidate genes … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 7,683 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAmelioration of Inducible Nitric Oxide Synthase, Insulin like Growth Factor-1 Gene Expression and Insulin Receptor Substrate-1 in Liver Tissue of Insulin Resistant Rats Treated With L-CarnitineHala M. GhanemProblem statement: It has been reported that genes expression (inducible Nitric Oxide (iNOS). Insulin-like Growth Factor-1(IGF-1) have a role in both glucose homeostasis and insulin resistance. The aim of this study was designed to evaluate the amelioration of the iNOS, IGF-1 genes expression as well as IRS-1 in liver tissues of rats fed high fructose diet treated with Lcarnitine. Approach: … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,264 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIn Vitro Metabolism Studies of Polybrominated Diphenyl Ethers Using Rat and Human Liver MicrosomesShun Wen Cheng, Kathleen Randall, Anne T. KotchevarA number of studies have recently reported the bioaccumulation of the commonly used fire retardants, Polybrominated Diphenyl Ethers (PBDEs), in humans and wildlife. Exposure of animals to PBDEs has been shown to result in developmental neurological, reproductive abnormalities and the disruption of endocrine function. Thyroid hormone equilibria was also shown to be altered by PBDE exposure. There is evidence that … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 3 · 30 Sep 2008 · 6,998 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleUltrastructural Evidences of Hepatitis B Infection in Human Liver Biopsies Disclose Complex Assembly and Morphogenesis Pathways for Hepatitis B VirusViviana Falcon, Ivon Menéndez, Nelson Acosta-Rivero et al.Despite of recent advances on acknowledge of hepatitis B virus (HBV) structure and biology, little is known about the morphogenesis and release of virions. In this study, the ultrastructural analysis of HBV components in liver biopsies from chronically HBV-infected patients disclosed complex assembly and morphogenesis pathways for HBV. HBV core (HBcAg) and surface (HBsAg) antigens were specifically identified in all … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 7,091 accessesView PDFCite