Research ArticleOpen accessIn the abstractFocal Adhesion Kinase: An Old Protein with New RolesAtul Kumar Pandey, Sonal Somvanshi, Vivek Pratap SinghFocal adhesion kinase, FAK is a tyrosine kinase which is prominently localized to focal adhesions and therefore its name, is an indispensable protein in integrin signaling. Since the discovery of FAK, this tyrosine kinase had been shown to regulate a variety of cell behavior like cell migration, proliferation, apoptosis and metastasis which makes this molecule at a centre stage of … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 13 Mar 2012 · 8,439 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Medicine-Prospects and ChallengesC. N. Ramchand, R. Sripathy, N. Somashekara et al.Drug discovery and development is a process that rationally leads to instigation of compound or formulation for the treatment of particular disease/diseased condition by acting on its specific target (s). Most of the drugs identified by conventional drug discovery process were as a result of unsystematic, random and serendipitous approach. Enhancement of knowledge in the field of biotechnology, molecular biology … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 23 Feb 2012 · 7,473 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn vitro Anti Plasmodial Activity of Enicostemma littoraleSanket Soni, Sarita GuptaProblem statement: Malaria is a prevalent disease in India. The problem of drug resistance is worsening. Hence, new effective and affordable antimalarial drugs are very much needed. The long-established use of quinine and the more recent introduction of artemisinin as highly effective anti malarials demonstrate that plant species are an important resource for the discovery of new anti malarial agents. … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 7,707 accessesView PDFCite
Research ArticleOpen accessIn the abstractAgent Based Grid Resource Discovery with Negotiated Alternate Solution and Non-Functional Requirement PreferencesP. Muthuchelvi, G.S. Anandha Mala, V. RamachandranProblem statement: As grid resources are geographically distributed, efficient resource discovery and management has become one of the important requirements. Besides, Grid users are independent identities and negotiation is necessary for reconciling their diverse characteristics. Therefore special mechanism was required to negotiate and discover the required resource or similar resource as an alternative when discovery fails. Moreover the quality of … …Journal of Computer Science, Vol. 5, Issue 3 · 31 Mar 2009 · 7,504 accessesView PDFCite
Research ArticleOpen accessIn the abstractAn Adjustable Sample Size Estimation Model for Usability AssessmentHaidar S. Jabbar, T.V. Gopal, Sattar J. AboudUsability assessment plays a fundamental role in discovering usability problems and the determination of the level of usability for a given software product. One crucial aspect in every usability assessment is the estimation of the sample size desired for a software product. Once we start estimating the sample size needed for a usability assessment, a baffling question comes in mind: … …American Journal of Applied Sciences, Vol. 4, Issue 8 · 31 Aug 2007 · 6,966 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Feasibility Study of Challenges and Opportunities in Computational Biology: A Malaysian PerspectiveR. J.A. Richard, N. SriraamThe term computational biology refers to the knowledge derived from a computer analysis of biological data that includes identification of genes in DNA sequence of different organisms, prediction of structural and functional mechanism of proteins, feature extraction and classification of genomics and proteomics. Computational biology is a rapidly developing branch of science and is highly interdisciplinary, using techniques and Concepts … …American Journal of Applied Sciences, Vol. 2, Issue 9 · 30 Sep 2005 · 6,924 accessesView PDFCite
EditorialOpen accessIn the abstractBig Data and Parkinson’s Disease - from Understanding of Disease to Personalised MedicineYen F. Tai, Nicola PaveseThe advancement of information technology in recent years has generated a huge amount of datasets in all areas of scientific research. This has led to new opportunities to harness the 'Big Data' to improve our understanding of diseases - from investigating disease mechanisms to monitoring treatment responses. The Big Data approach is a data-driven and often hypothesis-free, way of studying … …Neuroscience International, Vol. 7, Issue 1 · 27 Jul 2016 · 7,755 accessesView PDFCite
Special issueMaterial ScienceAmerican Journal of Engineering and Applied Sciences · 28 Feb 2016