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Research ArticleOpen accessIn the abstractQualitative Analysis of the Chemical Composition of Cinnamomum tamala leaves and Biological ActivityQianwen Gong, Pin Chen, Linyang Wang, Shuge TianCinnamomum tamala (Buch.-Ham.) Nees and Ebermaier. (Lauraceae) is a less explored medicinal plant in Uyghur medicine, with limited knowledge about its non-volatile compounds. We utilized chemical pre-screening in conjunction with UPLC-Q-Orbitrap-MS to analyze the phytochemical makeup of C. tamala leaves. Total polyphenols were measured using the Folin-Ciocalteu method, while total flavonoids were quantified through NaNO2-Al (NO3)3 colorimetric analysis across four … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 21 Sep 2026 · 659 accessesView PDFCite
Research ArticleOpen accessIn the abstractSeed Treatment-Based Biocontrol of Tomato Damping off Using Plant Essential Oil and Green Silver NanoparticlesLaila Reklaoui, Zine El Abidine Bzazou Elouazzani, El Touhami Tayebi Ouazzani et al.The fungal pathogen Rhizoctonia solani is a major causal agent of damping-off in tomato plants, leading to severe yield losses worldwide. Conventional fungicides, while effective, raise concerns regarding environmental safety and human health, highlighting the urgent need for sustainable alternatives. In this study, we report for the first time the use of Origanum compactum essential oil to biosynthesize silver nanoparticles … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 2 Jun 2026 · 1,298 accessesView PDFCite
Research ArticleOpen accessIn the abstractPurification, Structural Characterization and Anti-Aging and Stress Activities of Cordyceps Mycelium Polysaccharides from Paecilomyces HepialiXiaokang Hu, Huixiu Ma, Guicai Chen et al.This study identified and characterized the bioactive polysaccharide components from Cordyceps mycelium powder (CMP) derived from Paecilomyces hepiali, evaluating their anti-aging and stress-protective activities. Initial screening using Drosophila melanogaster revealed that crude Cordyceps polysaccharides (CCP) exhibited comparable effects to CMP and Cordyceps aqueous extracts (CAE) on natural lifespan and UV stress resistance, suggesting CCP as the primary bioactive component. CCP … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 16 Feb 2026 · 1,698 accessesView PDFCite
Research ArticleOpen accessIn the abstractModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,719 accessesView PDFCite
Research ArticleOpen accessIn the abstractApoptosis Inducer Capacity of Cardiotonic Steroids of Urginea maritima Extract on SH-SY5Y Neuroblastoma Cells, with Less Susceptibility among Neuron-Module CellsMaati M. Elghuol, Khalilah Abdul Khalil, Mazatulikhma Mat Zain, Mohamed Saifulaman Mohamed SaidNatural products have played a significant role in conventional treatment and in the development of new drugs for a wide range of illnesses, including malignant disease. Urginea maritima is classified as an herb is endemic to the Mediterranean area. This herb was renowned in traditional ethnopharmacological applications. Notwithstanding, there is a lack of evidence pertaining to the characterization of the … …American Journal of Applied Sciences, Vol. 13, Issue 5 · 28 May 2016 · 7,345 accessesView PDFCite
Research ArticleOpen accessIn the abstractGreen Synthesized Silver Nanoparticles Prepared from the Antimicrobial Crude Extracts of two Brown Seaweeds Against Plant PathogensAnnakodi Jothirethinam, Sivanantham Prathiba, Nagarajan Shanthi, Kulanthaiyesu ArunkumarThis study aimed for green synthesis of silver nanoparticles (Ag-NPs) from the antimicrobial crude extracted in chloroform: methanol(1:1 v/v) from the two brown seaweeds Spatoglossum asperum and Hedophyllum sessile active against two pathogenic bacteria (Xanthomonas axonopodis pv. citri and X. oryzae pv. oryzae) and a fungus Ustilaginoidea virens cause diseases in plants under in vitro assay. Crude extracts exhibit high … …Current Research in Nanotechnology, Vol. 6, Issue 2 · 5 Nov 2015 · 15,180 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of Panton-Valentine Leukocidin Toxin Induced Neutrophil Cell Lysis by Vancoplus in Methicillin-Resistant Staphylococcus Aureus InfectionsManu Chaudhary, Santosh Kumar Patnaik, Anurag PayasiPantone Valentine Leukocidin (PVL) is a cytotoxin associated with virulence of Methicillin-Resistant Staphylococcus aureus (MRSA). This study was undertaken to analyze the prevalence of PVL among MRSA strains and to study the effect of adjuvants (L-lysine, L-arginine, Ethylenediamine Tetraacetic Acid (EDTA) as well as drugs on PVL induced neutrophil cell lysis. Further, in vitro activity of Vancoplus, vancomycin, linezolid, teicoplanin … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 20 Dec 2014 · 7,106 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of Interleukin-6 Expression by Curcumin in Rat Vascular Smooth Muscle Explants In VitroYanti, Stephanie, Yuliani et al.In atherosclerotic plaques, infectious agents from microbes may release Lipopolysaccharide (LPS) and heat shock proteins that can stimulate the production of mediators, i.e., pro-inflammatory cytokines, by vascular endothelial cells and Smooth Muscle Cells (SMCs). The elevated level of Interleukin-6 (IL-6) is strongly associated with the development of atherosclerosis. Here, we investigated whether curcumin isolated from the rhizome of Curcuma longa … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 15 Dec 2014 · 6,774 accessesView PDFCite
Research ArticleOpen accessIn the abstractEMERGING METRONIDAZOLE RESISTANCE IN ANAEROBES AND MAPPING THEIR SUSCEPTIBILITY BEHAVIOURManu Chaudhary, Anurag PayasiIn the present study, anaerobic clinical isolates of Bacteroides fragilis, Escherichia coli, Staphylococcus aureus and Yersinia enterocolitica were obtained from different clinical specimens and were subjected to molecular typing to detect the gene encoding metronidazole resistance in these isolates. Subsequently, antibacterial activity of drugs was tested against the selected clinical isolates. A total of 53 clinical isolates involving 18 obligate … …American Journal of Infectious Diseases, Vol. 10, Issue 2 · 12 Apr 2014 · 9,192 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Silico and in Vitro Studies: Tryparedoxin Peroxidase Inhibitor Activity of Methotrexate for Antileishmanial ActivityRavi Kumar Gundampati, Shraddha Sahu, Avinash Kumar Srivastava et al.In order to understand the mechanism of molecular interactions at the active site of Tryparedoxin Peroxidase (Try P), homology modeling and docking studies were performed. We generated a Three-Dimensional (3D) model of target protein based on the Crystal structure of Leishmania Major Try PI (PDB ID: 3TUE) using modeler software. Docking analysis was carried out to study the effects of … …American Journal of Infectious Diseases, Vol. 9, Issue 4 · 28 Nov 2013 · 7,893 accessesView PDFCite