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40 results for “homeostasis”
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EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,629 accessesView PDFCite
Research ArticleOpen accessIn the abstractPotential of HMEC-1 Line and HUVEC Primary Culture Cells to Study the Neonatal IgG Fc Receptor in vitroLuz Belinda Ortiz-Alegría, Irma Cañedo-Solares, Felipe Vadillo-Ortega et al.The neonatal IgG Fc receptor (FcRn) plays an important role in IgG homeostasis and immunity passive transfer. Fine points regarding these mechanisms, however, are still emerging. In order to obtain information about these phenomena, it is essential to have in vitro models of endothelium that express this receptor. In this study we chose two widely used models of human endothelial … …American Journal of Immunology, Vol. 12, Issue 1 · 21 Mar 2016 · 9,455 accessesView PDFCite
EditorialOpen accessIn the abstractCommentary-How do we Improve Training for Receptor Research?Marilee Ann BenoreThis issue of the American Journal of Biochemistry and Biotechnology features articles about receptor-ligand interactions that are critical to the wellbeing of all living organisms. The importance of the field of receptor research is supported by the large number of articles published in journals, the numerous specialty journals, the international conferences and the percentage of legal drugs on the market … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 8 Dec 2015 · 8,058 accessesView PDFCite
Research ArticleOpen accessIn the abstractANTIOBESITY EFFECTS OF HUMAN SOLUBLE LEPTIN IN MICE NOURISHED WITH A HIGH-FAT/HIGH FRUCTOSE DIETB. Chimal-Vega, N. Paniagua-Castro, J. C. Perez-Rebollar et al.Leptin is a hormone that regulates energy balance. Since its discovery two decades ago, several efforts have been made to fully understand its role in metabolic regulation of feeding behavior, reproduction, glucose homeostasis, immune function, bone formation, lipid metabolism, among others. Its use as a therapeutic option in obese patients is still limited due to the syndrome known as Leptin … …American Journal of Agricultural and Biological Sciences, Vol. 9, Issue 3 · 9 Jul 2014 · 7,388 accessesView PDFCite
Research ArticleOpen accessIn the abstractTRANSCRIPTOMIC CHANGES IN RUMINAL TISSUE INDUCED BY THE PERIPARTURIENT TRANSITION IN DAIRY COWSLouis Dionissopoulos, Ousama AlZahal, Michael Alexander Steele et al.To understand how the capacity for fat metabolism (uptake, synthesis, modification) changes in rumen epithelia immediately before and after onset of lactation in dairy cows, rumen fluid Short Chain Fatty Acid (SCFA) concentrations and mRNA expression profiles of rumen epithelia was determined in twelve Holstein dairy cows at three weeks prior to calving (wk -3, n = 12), one week … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 1 · 13 Jan 2014 · 7,505 accessesView PDFCite
Research ArticleOpen accessIn the abstractRnai Induced Wing Modification in Leon Mutant Drosophila: A Developmental AnalysisSandeep Satapathy, Cheng Ting ChienThe precision of growth of an animal is meticulously regulated by extrinsic and intrinsic factors, with focus on maintenance of organismal homeostasis. The clue to change in physiology or metabolism of an organism, at times can be derived from the changes in phenotypes. In the Drosophila melanogaster model system, GAL 4-overexpressed RNAi driver males (Mini-White Marker), targeted against specific genes, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 4 · 20 Dec 2013 · 6,719 accessesView PDFCite
Research ArticleOpen accessIn the abstractPerioperative Care of Elderly Surgical PatientsAly SaberAdvancing age is characterized by functional impairment of the many regulatory processes that provide integration between organs and therefore, may lead failure to maintain homeostasis under conditions of physiological stress. There are two main factors helping to identify the high risk for surgery. The first relates to the type of surgery and the second to the scope of cardiopulmonary functional … …Current Research in Medicine, Vol. 4, Issue 1 · 12 Apr 2013 · 8,014 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Thai Style Stretching Exercise on "Ruesi Dud Ton" on Physical Health and Oxidative Stress in Healthy VolunteerJintanaporn Wattanathorn, Tasanee Boonterm, Wipawee Thukhummee et al.Despite the health benefit reputation of Thai stretching exercise "Ruesi dud ton", no scientific evidence is available. Therefore, we aimed to determine the effect of Thai style stretching exercise on physical health and oxidative stress markers including Malondialdegyde (MDA) level and the activities of main scavenger enzymes including Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GSH-Px). We had determined … …OnLine Journal of Biological Sciences, Vol. 12, Issue 4 · 22 Feb 2013 · 7,743 accessesView PDFCite
Research ArticleOpen accessIn the abstractSclerostin: A Novel Key to Bone and Dental TreatmentGalli Carlo, Lumetti Simone, Manfredi Edoardo et al.Problem statement: Tooth loss can induce dramatical remodeling of alveolar bone because of mechanical loading impairment and strategies to help maintain adequate bone levels for subsequent therapies are sorely needed. Recent discoveries have shown that osteocytes, matrix-embedded cells in bone, respond to mechanical stimulation by modulating the expression of the Sost gene, which encodes for the protein sclerostin. This protein … …Current Research in Dentistry, Vol. 3, Issue 1 · 1 Jan 2013 · 8,161 accessesView PDFCite
Research ArticleOpen accessIn the abstractBIOENERGETICS, THE FOUNDATION OF THE FUTURE OF CANCER THERAPEUTICS A QUANTUM LEAP IN MAKINGKambiz AfrasiabiDeep understanding of the governing laws of bioenergetics of the living organism and dissection of their aberrancies, could enable us to design new treatment strategies for a vast array of disorders including malignancy and could potentially lead to major breakthroughs and cure of these devastating disorders. The modern treatment strategies currently aim at identification of a pathway considered to be … …OnLine Journal of Biological Sciences, Vol. 12, Issue 3 · 15 Aug 2012 · 7,531 accessesView PDFCite