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48 results for “genetic association”
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Research ArticleOpen accessIn the abstractStudy on Follicle Stimulating Hormone Receptor Gene Polymorphisms in South Indian Women with Polycystic Ovarian SyndromeHimavanth Reddy Kambalachenu, Solomon Franklin Durairaj Paul, Sanjeeva Reddy Nellepalli, Perumal VenkatachalamPolycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder of women in their reproductive ages. Though PCOS is a complex, heterogeneous disorder, but there is strong evidence for its genetic predisposition. The aim was to study the association of Follicle Stimulating Hormone Receptor (FSHR) gene polymorphisms rs1394205, rs6165 and rs6166 in south Indian women with PCOS. The present case … …Current Research in Medicine, Vol. 4, Issue 2 · 4 Sep 2013 · 12,695 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociation of Polymorphism in Growth and Differentiation Factor 5 Gene with Osteoarthritis KneeAbhishek Mishra, Divya Sanghi, Amar Chandra Sharma et al.The present study investigated to identify the association of polymorphism in GDF-5 gene with osteoarthritis in North Indian population. In a case-control study, 300 cases with knee osteoarthritis and an equal number of age and gender matched healthy controls were included. Cases were diagnosed using the ACR Guidelines of Knee Osteoarthritis (KOA). Clinical symptoms were assessed with the knee specific … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 1 · 18 Mar 2013 · 9,417 accessesView PDFCite
Research ArticleOpen accessIn the abstractG-2548A Leptin Promoter and Q223R Leptin Receptor Polymorphisms in Obese Mexican SubjectsP. Carrillo-Vazquez Jonathan, Lopez-Alcantar Jeronimo, Chimal-Vega Brenda et al.Leptin interaction with its receptor in the hypothalamus stimulates a specific signaling cascade that results in the synthesis of anorexigenic and orexigenic peptides in order to regulate food intake and energy expenditure. Many polymorphisms in leptin (lep) and leptin receptor (lepr) genes have been associated with body weight. In particular, G-2548A in the lep promoter and Q223R in lepr variants … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 1 · 12 Feb 2013 · 8,641 accessesView PDFCite
Research ArticleOpen accessIn the abstractBayesian Exploration of Multilocus Interactions on the Genome-Wide ScaleIvan Kozyryev, Jing ZhangProblem statement: Recent technological and scientific advances propelled the field of Genome-Wide Association Study (GWAS), which promises to be instrumental in linking many common complex diseases to their genetic origin. While so far such large-scale surveys have been moderately successful in identifying disease related genetic variants, much of disease heritability is still not accounted for by the discovered loci. There … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 2 Jul 2012 · 7,401 accessesView PDFCite
Research ArticleOpen accessIn the abstractHigh-Order Interactions in Rheumatoid Arthritis Detected by Bayesian Method using Genome-Wide Association Studies DataJing Zhang, Zheyang Wu, Chao Gao, Michael Q. ZhangProblem statement: In order to reveal the missing genetic component of Rheumatoid Arthritis (RA) susceptibility, we carried out a genome-wide high-order epistatic interaction study for RA. Approach: A powerful Bayesian strategy was applied to analyze the data of Genome-Wide Association Studies (GWAS) from the Welcome Trust Case Control Consortium (WTCCC), where 319 high-order interactions were found across the whole genome … …Current Research in Medicine, Vol. 3, Issue 1 · 30 Mar 2012 · 8,379 accessesView PDFCite
Research ArticleOpen accessIn the abstractCharacterization of the Genetic Diversity of Peach Cultivars in Taif by RAPD-PCRMohamed A. Nagaty, Salah El-Din El-Assal, Mahmoud M. RifaatProblem statement: Peach genotypes from the Kingdom of Saudi Arabia were not adequately characterized at the biological and molecular levels. This study was carried out to characterize nine peach cultivars growing in Taif (KSA) at the biological and molecular levels. Approach: For the nine peach cultivars studied, flowering and fruiting indices were determined and eight, 10-base primers were used to … …American Journal of Applied Sciences, Vol. 8, Issue 7 · 24 Jun 2011 · 7,271 accessesView PDFCite
Research ArticleOpen accessIn the abstractSummarizing Relational Data Using Semi-Supervised Genetic Algorithm-Based Clustering TechniquesRayner AlfredProblem statement: In solving a classification problem in relational data mining, traditional methods, for example, the C4.5 and its variants, usually require data transformations from datasets stored in multiple tables into a single table. Unfortunately, we may loss some information when we join tables with a high degree of one-to-many association. Therefore, data transformation becomes a tedious trial-and-error work and … …Journal of Computer Science, Vol. 6, Issue 7 · 31 Jul 2010 · 7,585 accessesView PDFCite
Research ArticleOpen accessIn the abstractGenetic Diversity Analysis of the Gohilwari Breed of Indian Goat (Capra hircus) Using Microsatellite MarkersSubodh Kumar, S. P. Dixit, N. K. Verma et al.Problem statement: Gohilwari breed of goat is a multipurpose goat mainly for milk and meat purposes and best suited in its harsh climatic condition. This breed is inadequately characterized till now at DNA level. So the present study was undertaken for population genetic analysis at molecular level to exploit the breed for planning sustainable improvement, conservation and utilization, which subsequently … …American Journal of Animal and Veterinary Sciences, Vol. 4, Issue 3 · 30 Sep 2009 · 8,925 accessesView PDFCite
Research ArticleOpen accessIn the abstractEnvironmental Factors and Limbic Vulnerability in Childhood AutismRichard LatheThe rise in prevalence of autism spectrum disorders (ASD) is suggestive of a new etiology. Diagnostic substitution alone is unlikely to account for the increase, while genetic association with detoxification gene alleles points to an environmental contribution. Subtle structural anomalies in the ASD brain are widespread but limbic damage seems important for the development of behaviors diagnostic of ASD. The … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,678 accessesView PDFCite
Research ArticleOpen accessIn the abstractFeature Selection in Data-Mining for Genetics Using Genetic AlgorithmV. N. Rajavarman, S. P. RajagopalanWe discovered genetic features and environmental factors which were involved in multifactorial diseases. To exploit the massive data obtained from the experiments conducted at the General Hospital, Chennai, data mining tools were required and we proposed a 2-Phase approach using a specific genetic algorithm. This heuristic approach had been chosen as the number of features to consider was large (upto … …Journal of Computer Science, Vol. 3, Issue 9 · 30 Sep 2007 · 6,627 accessesView PDFCite